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  4. Recombinant Mouse MKL/myocardin-like protein 2 (Mkl2), partial

Recombinant Mouse MKL/myocardin-like protein 2 (Mkl2), partial

  • 中文名稱：
    小鼠Mkl2重組蛋白
  • 貨號：
    CSB-YP014601MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mkl2重組蛋白
  • 貨號：
    CSB-EP014601MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mkl2重組蛋白
  • 貨號：
    CSB-EP014601MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mkl2重組蛋白
  • 貨號：
    CSB-BP014601MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mkl2重組蛋白
  • 貨號：
    CSB-MP014601MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Mkl2
  • Uniprot No.：
  • 別名：
    Mrtfb; Mkl2; Myocardin-related transcription factor B; MRTF-B; MKL/myocardin-like protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.
  • 基因功能參考文獻：
    1. Smad2 interaction with MRTFB seems to be a novel and important mechanism underlying neural crest cell differentiation to vascular smooth muscle cells. PMID: 23817199
    2. MRTF-B knockdown leads to increase in S and G2/M populations and downregulation of cyclin-CDK inhibitors p27Kip1, p18Ink4c and 19Ink4d as well as upregulation of p21Waf1 and cyclin D1. PMID: 23656782
    3. MKL2 regulates a conserved TGF-beta signaling pathway that is required for angiogenesis and ultimately embryonic survival. PMID: 22899851
    4. show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B and the signaling factor Fgf10 PMID: 21704027
    5. Consistent with the pattern of expression, E10.5 and E11.5 MRTF-B-/- mutants exhibit deformation of aortic arch arteries 3, 4, and 6 and severe attenuation of smooth muscle cell differentiation in the arch arteries and the aorticopulmonary septum. PMID: 15951419
    6. MRTF-B plays a critical role in regulating differentiation of cardiac neural crest cells into smooth muscle. PMID: 15951419
    7. Data show that mice homozygous for a myocardin-related transcription factor-B loss-of-function mutation die during mid-gestation from a spectrum of cardiovascular defects. PMID: 16204380
    8. MRTF-B has a unique role in regulating smooth muscle genes important for liver, yolk sac, and portal vascular development. PMID: 17183527
    9. This review focuses on the role MRTF-B plays in regulating cardiovascular patterning, vascular smooth muscle cell and cardiomyocyte differentiation, and in the pathogenesis of congenital heart disease and vascular proliferative syndromes. PMID: 17363709

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Widely expressed. High expression in heart, brain and testis. Lower expression in lung, liver and kidney.
  • 數據庫鏈接：


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