在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse KH domain-containing, RNA-binding, signal transduction-associated protein 3 (Khdrbs3)

Recombinant Mouse KH domain-containing, RNA-binding, signal transduction-associated protein 3 (Khdrbs3)

  • 中文名稱：
    小鼠Khdrbs3重組蛋白
  • 貨號：
    CSB-YP890109MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Khdrbs3重組蛋白
  • 貨號：
    CSB-EP890109MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Khdrbs3重組蛋白
  • 貨號：
    CSB-EP890109MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Khdrbs3重組蛋白
  • 貨號：
    CSB-BP890109MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Khdrbs3重組蛋白
  • 貨號：
    CSB-MP890109MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Khdrbs3
  • Uniprot No.：
  • 別名：
    Khdrbs3; Salp; Slm2; KH domain-containing; RNA-binding; signal transduction-associated protein 3; RNA-binding protein Etoile; Sam68-like mammalian protein 2; SLM-2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-346
  • 氨基酸序列
    MEEKYLPELM AEKDSLDPSF THALRLVNRE IEKFQKGEGK EEEKYIDVVI NKNMKLGQKV LIPVKQFPKF NFVGKLLGPR GNSLKRLQEE TLTKMSILGK GSMRDKAKEE ELRKSGEAKY FHLNDDLHVL IEVFAPPAEA YARMGHALEE IKKFLIPDYN DEIRQAQLQE LTYLNGGSEN ADVPVVRGKS TLRTRGVTTP AITRGRGGVT ARPVAVGVPR GTPTPRGVLS TRGPVSRGRG LLTPRARGVP PTGYRPPPPP PTQETYGEYD YDDGYGTAYD EQSYDSYDNS YSTPAQSAAD YYDYGHGLSE DAYDSYGQEE WTNSRHKAPS ARTAKGVYRD QPYGRY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. High concentrations in forebrain structures block splicing inclusion of NRXN1-3 AS4 exons while low concentrations favor their inclusion. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity and is linked to behavioral aspects. Regulates expression of KHDRBS2/SLIM-1 in defined neuron populations in the hippocampus by modifying its alternative splicing resulting in a transcript predicted to undergo nonsense-mediated decay. Can bind FABP9 mRNA. May play a role as a negative regulator of cell growth. Inhibits cell proliferation.
  • 基因功能參考文獻：
    1. Our data reveal a pathway of SLM2 homeostatic auto-regulation controlling brain network activity and behavior PMID: 28009295
    2. (Nrxn) is a critical element in selective trans-synaptic interactions. This study evaluated the synaptogenic receptor activity of NL1/2/3 isoforms in a neuron-fibroblast co-culture system, in which the Nrxn AS4 segments are manipulated using SLM2, a selective and dominant regulator of AS4 splicing. PMID: 28939043
    3. this study found that the RNA-binding protein SLM2 is essential for functional specification of glutamatergic synapses in the mouse hippocampus. PMID: 27174676
    4. Sam68 and T-STAR could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA. PMID: 26758068
    5. A hierarchical, SLM2-dependent mechanism in hippocampus was identified for cell type-specific expression of neuronal splicing regulators. PMID: 25505328
    6. 10 target mRNA substrates from testis extract are bound by T-STAR. PMID: 19916944
    7. expression of active BRK/Sik results in increased SLM-1 and SLM-2 phosphorylation which has functional relevance and leads to inhibition of their RNA-binding PMID: 15471878

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
  • 蛋白家族：
    KHDRBS family
  • 組織特異性：
    Highly expressed in testis and brain. In adult cerebellum expressed predominantly in internal granular layer interneurons and in hippocampus is exclusively expressed in CA neurons; expression is restricted to neuronal subpopulations largely non-overlappin
  • 數據庫鏈接：


主站蜘蛛池模板： 国内精品无码一区二区三区| 无码夜色一区二区三区| yy111111少妇无码理论片| 国产草莓精品国产av片国产| 欧美丰满肥婆videos| 无码熟妇人妻av在线网站| 伦埋琪琪久久影院三级| 亚洲精品久久一区二区三区777| 亚洲人成色4444在线观看| 亚洲熟女精品中文字幕| 一本大道久久香蕉成人网| 丰满少妇人妻hd高清大乳在线| 欧美一区二区三区红桃小说| 久久久久成人精品免费播放动漫| 成人精品视频一区二区三区尤物| 69成人免费视频无码专区| 亚洲熟女av乱码在线观看漫画| 撕开奶罩揉吮奶头视频| 99国产精品白浆在线观看免费 | 超碰97久久国产精品牛牛 | 亚洲精品92内射| 成年午夜性影院免费观看| 无码中文字幕va精品影院| 久久久国产精品麻豆a片| 精品深夜av无码一区二区老年| 国产大屁股视频免费区| 中文字幕在线精品视频入口一区| 日韩中文亚洲欧美视频二| 免费99精品国产自在在线| 日本少妇高潮喷水视频| 日本亚洲欧美高清专区vr专区| 久久久婷婷五月亚洲97色| 亚洲中文字幕无码永久在线不卡| 欧美freesex黑人又粗又大| 无码区日韩特区永久免费系列| 亚洲精品无码乱码成人| 精品无码一区二区三区av| 国产三级精品三级在专区| 午夜成人无码片在线观看影院| 亚洲精品一区二区三区影院 | 884aa四虎影成人精品|