在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Islet amyloid polypeptide (Iapp)

Recombinant Mouse Islet amyloid polypeptide (Iapp)

  • 中文名稱：
    小鼠Iapp重組蛋白
  • 貨號(hào)：
    CSB-YP010931MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Iapp重組蛋白
  • 貨號(hào)：
    CSB-EP010931MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Iapp重組蛋白
  • 貨號(hào)：
    CSB-EP010931MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Iapp重組蛋白
  • 貨號(hào)：
    CSB-BP010931MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Iapp重組蛋白
  • 貨號(hào)：
    CSB-MP010931MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    IappIslet amyloid polypeptide; Amylin; Diabetes-associated peptide; DAP
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Cytoplasmic domain
  • 表達(dá)區(qū)域：
    38-74
  • 氨基酸序列
    KCN TATCATQRLA NFLVRSSNNL GPVLPPTNVG SNTY
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

相關(guān)產(chǎn)品

靶點(diǎn)詳情

  • 功能：
    Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
  • 基因功能參考文獻(xiàn)：
    1. These data provide for the first time evidences for the toxic nature of oligomeric assemblies of murine amylin and its existence in wild-type, non-transgenic mice. PMID: 29372531
    2. Circulating aggregated amylin accumulates preferentially in male vs. female hearts and its effects on myocyte Ca(2+) cycling do not require diabetic remodeling of the myocardium. PMID: 29066284
    3. Results suggest that amylin directly acts, through a p-ERK-mediated process, on POMC neurons to enhance arcuate nucleus-paraventricular nucleus alphaMSH pathway development. PMID: 29467172
    4. These data suggest participation by both soluble and fibrillar aggregates in IAPP-induced islet inflammation. IAPP-induced activation of TLR2 and secretion of IL-1 may be important therapeutic targets to prevent amyloid-associated beta cell dysfunction. PMID: 26786104
    5. Hypothalamic amylin is transcriptionally regulated by leptin, that it can act directly on ObRb neurons in concert with leptin, and that it regulates feeding. PMID: 26655697
    6. Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity. PMID: 26483547
    7. Study the physiologic actions of IAPP on pancreatic beta cells, which secrete this peptide together with insulin upon glucose stimulation. Explore the signaling pathways and mitogenic actions of IAPP on beta cells. PMID: 25808537
    8. deletion of the DeltaN isoforms of p63 or p73 leads to metabolic reprogramming and regression of p53-deficient tumours through upregulation of IAPP, the gene that encodes amylin, a 37-amino-acid peptide co-secreted with insulin by the beta cells of the pancreas PMID: 25409149
    9. The stability, conformational dynamics and association force of different single-layer models of the full-length wild-type and glycine mutants of amylin, were investigated. PMID: 24028418
    10. MMP-9 constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP. PMID: 23229548
    11. Data suggest that amylin and leptin play additive roles in regulating energy homeostasis via activation of overlapping signalling pathways; mechanisms may be different in hypothalamus, muscle, and liver and in cases of endoplasmic reticulum stress. PMID: 21997794
    12. These findings point to a potential for Drosophila melanogaster to serve as a model system for studies of hproIAPP and hIAPP expression with subsequent aggregation and developed pathology. PMID: 21695120
    13. This study demonstrated that amylin inactivation leads to a low bone mass due to an increase in bone resorption whereas bone formation is unaffected. PMID: 14970190
    14. Fatty acids differently regulate amylin and insulin expression and induce both amylin and insulin release PMID: 19843871
    15. Amylin/leptin's marked weight- and fat-reducing effects are due to activation of intrinsic synergistic neuronal signaling pathways. PMID: 19875640
    16. expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas PMID: 12049785
    17. IAPP has complex effects on islet hormone secretion serving as an inhibitor of glucagon release and having a dual action on insulin secretion. PMID: 12609749
    18. Functional role of the -132 G/A mutation reported in the promoter region of the IAPP gene. PMID: 15243700
    19. analysis of pro-islet amyloid polypeptide processing in the constitutive and regulated secretory pathways of beta cells PMID: 15802374
    20. Reduced expression in gastrin-cholecystokinin knockout mice. PMID: 16002530
    21. Non-amyloidogenic mouse IAPP has a pronounced ability to insert into phospholipid monolayers, even at lipid packing conditions that exceed the conditions that occur in biological membranes. PMID: 16403520
    22. This study demonstrates that amylin deficiency exerts effects on bone during growth that are sex-dependent and suggest a possible interaction between amylin and testosterone, growth factors, or cytokines to regulate bone cell metabolism. PMID: 16830202
    23. Findings demonstrate that inhibition of IAPP synthesis prevents amyloid formation and beta-cell death in cultured human islets. PMID: 18694973

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Calcitonin family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:15874

    STRING: 10090.ENSMUSP00000043956

    UniGene: Mm.415



主站蜘蛛池模板： 精品国产精品三级精品av网址| 伊人久久综合无码成人网| 99精品人妻少妇一区二区| 少妇人妻偷人精品视蜜桃| 成人一区二区免费视频| 午夜dv内射一区二区| 大地资源网第二页免费观看| 波多野结衣久久一区二区| 久久香蕉国产线看观看手机| 国产免费人成在线视频网站| 国产 中文 制服丝袜 另类| 日韩成人无码影院| 欧美精品乱码99久久蜜桃| 国产av中文av无码av狼人| 国产亚洲精品第一综合另类| 亚洲午夜成人片| 99久久久无码国产精品秋霞网| 神马午夜福利不卡片在线| 精品一品国产午夜福利视频| 亚洲成av人片不卡无码| 国产精品高清视亚洲中文| 国产av福利第一精品| 亚洲欧洲日产国码无码| 艳妇臀荡乳欲伦交换h在线观看| 欧美96在线 | 欧| 一本一道色欲综合网| 国产精品美女久久久久av爽| 丰满少妇被猛烈进入高清播放| 大香线蕉伊人精品超碰| 亚洲男男无套gv大学生| 领导边摸边吃奶边做爽在线观看| 精品偷自拍另类在线观看| 国色天香精品一卡2卡3卡4 | 区二区三区玖玖玖| 男女做爰猛烈啪啪吃奶动 | 欧美日韩国产精品| 欧美成人看片一区二区三区尤物| 饥渴少妇做私密保健视频| 国产又色又刺激高潮视频| 亚洲日韩欧美国产高清αv| 成人乱人伦视频在线观看|