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  4. Mouse Amylin ELISA Kit

Mouse Amylin ELISA Kit

  • 中文名稱：
    小鼠胰淀素(Amylin)酶聯免疫試劑盒
  • 貨號：
    CSB-E08538m
  • 規格：
    96T/48T
  • 價格：
    ￥3800/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠胰淀素(Amylin)酶聯免疫試劑盒（CSB-E08538m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IAPP含量。IAPP即胰島淀粉樣多肽，是胰島β細胞分泌的一種多肽。它與糖尿病等疾病密切相關，其異常聚集形成的淀粉樣沉積物會損害β細胞功能、影響胰島素分泌。目前研究聚焦于其聚集機制及如何抑制聚集，以探索疾病治療新途徑。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，包括糖尿病發病機制探索、肥胖相關代謝信號通路分析、動物模型胰腺功能評估及藥物干預效果研究等本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    IappIslet amyloid polypeptide ELISA Kit; Amylin ELISA Kit; Diabetes-associated peptide ELISA Kit; DAP ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse amylin in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 107
    Range % 103-110
    1:2 Average % 89
    Range % 85-93
    1:4 Average % 102
    Range % 98-106
    1:8 Average % 85
    Range % 81-89
  • 回收率：
    The recovery of mouse amylin spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 99 95-103
    EDTA plasma (n=4) 86 83-89
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1600 1.949 2.012 1.981 1.868
    800 1.523 1.502 1.513 1.400
    400 1.021 0.998 1.010 0.897
    200 0.653 0.672 0.663 0.550
    100 0.465 0.438 0.452 0.339
    50 0.297 0.301 0.299 0.186
    25 0.183 0.180 0.182 0.069
    0 0.112 0.114 0.113 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
  • 基因功能參考文獻：
    1. These data provide for the first time evidences for the toxic nature of oligomeric assemblies of murine amylin and its existence in wild-type, non-transgenic mice. PMID: 29372531
    2. Circulating aggregated amylin accumulates preferentially in male vs. female hearts and its effects on myocyte Ca(2+) cycling do not require diabetic remodeling of the myocardium. PMID: 29066284
    3. Results suggest that amylin directly acts, through a p-ERK-mediated process, on POMC neurons to enhance arcuate nucleus-paraventricular nucleus alphaMSH pathway development. PMID: 29467172
    4. These data suggest participation by both soluble and fibrillar aggregates in IAPP-induced islet inflammation. IAPP-induced activation of TLR2 and secretion of IL-1 may be important therapeutic targets to prevent amyloid-associated beta cell dysfunction. PMID: 26786104
    5. Hypothalamic amylin is transcriptionally regulated by leptin, that it can act directly on ObRb neurons in concert with leptin, and that it regulates feeding. PMID: 26655697
    6. Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity. PMID: 26483547
    7. Study the physiologic actions of IAPP on pancreatic beta cells, which secrete this peptide together with insulin upon glucose stimulation. Explore the signaling pathways and mitogenic actions of IAPP on beta cells. PMID: 25808537
    8. deletion of the DeltaN isoforms of p63 or p73 leads to metabolic reprogramming and regression of p53-deficient tumours through upregulation of IAPP, the gene that encodes amylin, a 37-amino-acid peptide co-secreted with insulin by the beta cells of the pancreas PMID: 25409149
    9. The stability, conformational dynamics and association force of different single-layer models of the full-length wild-type and glycine mutants of amylin, were investigated. PMID: 24028418
    10. MMP-9 constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP. PMID: 23229548
    11. Data suggest that amylin and leptin play additive roles in regulating energy homeostasis via activation of overlapping signalling pathways; mechanisms may be different in hypothalamus, muscle, and liver and in cases of endoplasmic reticulum stress. PMID: 21997794
    12. These findings point to a potential for Drosophila melanogaster to serve as a model system for studies of hproIAPP and hIAPP expression with subsequent aggregation and developed pathology. PMID: 21695120
    13. This study demonstrated that amylin inactivation leads to a low bone mass due to an increase in bone resorption whereas bone formation is unaffected. PMID: 14970190
    14. Fatty acids differently regulate amylin and insulin expression and induce both amylin and insulin release PMID: 19843871
    15. Amylin/leptin's marked weight- and fat-reducing effects are due to activation of intrinsic synergistic neuronal signaling pathways. PMID: 19875640
    16. expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas PMID: 12049785
    17. IAPP has complex effects on islet hormone secretion serving as an inhibitor of glucagon release and having a dual action on insulin secretion. PMID: 12609749
    18. Functional role of the -132 G/A mutation reported in the promoter region of the IAPP gene. PMID: 15243700
    19. analysis of pro-islet amyloid polypeptide processing in the constitutive and regulated secretory pathways of beta cells PMID: 15802374
    20. Reduced expression in gastrin-cholecystokinin knockout mice. PMID: 16002530
    21. Non-amyloidogenic mouse IAPP has a pronounced ability to insert into phospholipid monolayers, even at lipid packing conditions that exceed the conditions that occur in biological membranes. PMID: 16403520
    22. This study demonstrates that amylin deficiency exerts effects on bone during growth that are sex-dependent and suggest a possible interaction between amylin and testosterone, growth factors, or cytokines to regulate bone cell metabolism. PMID: 16830202
    23. Findings demonstrate that inhibition of IAPP synthesis prevents amyloid formation and beta-cell death in cultured human islets. PMID: 18694973

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Calcitonin family
  • 數據庫鏈接：

    KEGG: mmu:15874

    STRING: 10090.ENSMUSP00000043956

    UniGene: Mm.415



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