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  4. Recombinant Mouse Intraflagellar transport protein 88 homolog (Ift88), partial

Recombinant Mouse Intraflagellar transport protein 88 homolog (Ift88), partial

  • 中文名稱：
    小鼠Ift88重組蛋白
  • 貨號：
    CSB-YP717210MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ift88重組蛋白
  • 貨號：
    CSB-EP717210MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ift88重組蛋白
  • 貨號：
    CSB-EP717210MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ift88重組蛋白
  • 貨號：
    CSB-BP717210MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ift88重組蛋白
  • 貨號：
    CSB-MP717210MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ift88
  • Uniprot No.：
  • 別名：
    Ift88; Tg737; Tg737Rpw; TgN737Rpw; Ttc10; Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737; Tetratricopeptide repeat protein 10; TPR repeat protein 10; TgN(Imorpk)737Rpw
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
  • 基因功能參考文獻：
    1. Tg737 regulates a Wnt/beta-catenin/Snail-HNF4alpha negative feedback circuit, thereby blocking EMT and the malignant transformation of liver stem cells to liver cancer stem cells. PMID: 28536011
    2. genetically ablated Kif3a, Ift88, and Ttc21b in a series of specific spatiotemporal domains. The resulting phenotypes allow us to draw several conclusions. First, we conclude that the Ttc21b cortical phenotype is not due to the activity of Ttc21b within the brain itself PMID: 28291836
    3. In order to evaluate the function of IFT88 in regulating craniofacial development, we generated Wnt1-Cre;Ift88fl/fl mice to eliminate Ift88 specifically in cranial neural crest (CNC) cells. Wnt1-Cre;Ift88fl/flpups died at birth due to severe craniofacial defects including bilateral cleft lip and palate and tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme PMID: 28069795
    4. IFT88 influences chondrocyte actin organization and biomechanics. PMID: 26493329
    5. Results suggest that EGF exerts mitogenic effects in the orpk cilia (-) cells via activation of growth-associated amiloride-sensitive NHEs and ERK. PMID: 25055824
    6. We propose that Ift88 and primary cilia regulate expression of Sfrp5 and Wnt signaling pathways in growth plate via regulation of Ihh signaling. PMID: 23034798
    7. Knockout of Bbs7 combined with a hypomorphic Ift88 allele (orpk as a model for Shh dysfuction) results in embryonic lethality with e12.5 embryos having exencephaly, pericardial edema, cleft palate and abnormal limb development. PMID: 22228099
    8. Data show that IFT88 is present in the Golgi of spermatids, that the microtubule-associated golgin GMAP210 and IFT88 participate in acrosome, HTCA, and tail biogenesis. PMID: 21337470
    9. Epidermal cilia function was analyzed using conditional alleles of the ciliogenic genes Ift88 and Kif3a. PMID: 21429982
    10. Data show that IFT88 depletion induces mitotic defects in human cultured cells, in kidney cells from the IFT88 mouse mutant Tg737(orpk) and in zebrafish embryos. PMID: 21441926
    11. is required for assembly of renal cilium. PMID: 11832437
    12. The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. PMID: 12239239
    13. Data suggest a dosage effect of Tg737 on the limb phenotypes in observed skeletal pathologic conditions. PMID: 12701101
    14. ORPK has a developmental role in kidney cilia length and number PMID: 15226261
    15. polaris has a role in proper development of articular cartilage and growth plate PMID: 17289363
    16. Ther intraflagellar transport component polaris localized to nascent centrioles before incorporation into cilia, and depletion of polaris blocked axoneme formation. PMID: 17606865
    17. Study shows that genetic inactivation of a ciliary gene, Ift88, leads to misorientation of stereociliary bundles and to shortening and widening of the cochlea and its sensory organ, indicating a requirement for Ift88 in planar cell polarity regulation. PMID: 18066062
    18. The Ift88Tg737Rpw mutation impairs intraflagellar transport (IFT), a process required for assembly of motile and immotile cilia PMID: 18366137
    19. Deletion of Ift88 in ovary using Cre-Lox recombination in mice resulted in a severe delay in mammary gland development including lack of terminal end bud structures, alterations in the estrous cycle, and impaired ovulation PMID: 18629867
    20. Uncovered by N-ethyl-N-nitrosourea-mutagenesis, cobblestone is a hypomorphic allele of the IFT gene Ift88, in which Ift88 mRNA and protein levels are reduced by 70-80%. cobblestone mutants are distinguished by subpial heterotopias in the forebrain. PMID: 19036983
    21. a critical primary cilium component [with] essential role in cranial base development and chondrocyte maturation PMID: 19587160
    22. Polycystin-2 is localized to kidney cilia and the levels are elevated in cilia in the Tg737 mouse. PMID: 12062067
    23. The Tg737 gene product is essential for vertebrate photoreceptor assembly and maintenance. PMID: 11916979
    24. The Tg737 gene product is a subunit of the intraflagellar transport particle and is required for assembly of kidney primary cilia PMID: 11062270

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  • 相關疾病：
    Defects in Ift88 are the cause of recessive bilateral polycystic kidney disease (PKD) with collecting duct and tubule ectasia, and a liver lesion involving biliary dysplasia and/or portal fibrosis.
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium, flagellum.
  • 組織特異性：
    Testis.
  • 數據庫鏈接：


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