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  4. Recombinant Mouse Insulin-like growth factor-binding protein 7 (Igfbp7)

Recombinant Mouse Insulin-like growth factor-binding protein 7 (Igfbp7)

  • 中文名稱：
    小鼠Igfbp7重組蛋白
  • 貨號：
    CSB-YP713980MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Igfbp7重組蛋白
  • 貨號：
    CSB-EP713980MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Igfbp7重組蛋白
  • 貨號：
    CSB-EP713980MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Igfbp7重組蛋白
  • 貨號：
    CSB-BP713980MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Igfbp7; Mac25Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; MAC25 protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    26-281
  • 氨基酸序列
    SSSDA CGPCVPASCP ALPRLGCPLG ETRDACGCCP VCARGEGEPC GGGAAGRGHC APGMECVKSR KRRKGKAGAA AGGPATLAVC VCKSRYPVCG SNGITYPSGC QLRAASLRAE SRGEKAITQV SKGTCEQGPS IVTPPKDIWN VTGAKVFLSC EVIGIPTPVL IWNKVKRDHS GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DAGEYECHAS NSQGQASAAA KITVVDALHE IPLKKGEGAQ L
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
  • 基因功能參考文獻：
    1. Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses hepatocellular carcinoma PMID: 28619711
    2. Study shows that IGFBP7 contributes significantly to mesenchymal stromal cells (MSC)-mediated immune modulation, as is shown by decreasing ability of IGFBP7 knockdown in MSCs to restore proliferation and cytokine production in T-cells. PMID: 27397633
    3. data suggest that IGFBP-7 was up regulated during EAE and inhibit the transition from OPCs to mature OLs, implying its use as a potential therapeutic target for the treatment of inflammatory demyelinating diseases PMID: 25819415
    4. Our data suggest that loss of Igfbp7 induces precocious involution possibly through diminished cell survival signals. PMID: 24505323
    5. Angiomodulin is necessary for cardiac commitment of embryonic stem cells (ESCs) and its regulation depends on TAp63 isoform. PMID: 24145187
    6. a model whereby IGFBP7 binds to unoccupied IGF1R and suppresses downstream signaling, thereby inhibiting protein synthesis, cell growth, and survival. PMID: 23250396
    7. IGFBP7 has a novel role in mouse uterus: it is regulating uterine receptivity through Th1/Th2 lymphocyte balance and decidualization. PMID: 23028860
    8. fear extinction-induced IGF2/IGFBP7 signalling promotes the survival of 17-19-day-old newborn hippocampal neurons PMID: 21873981
    9. Results demonstrate that the vascular-specific marker angiomodulin (AGM) modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A. PMID: 19542015
    10. study showed that IGFBP-rP1 (IGFBP7) was expressed in dysregulated podocytes in a human immunodeficiency virus-associated nephropathy model and in immature podocytes in the developing kidney; conclude that IGFBP-rP1 may be a product of injured podocytes PMID: 20630940
    11. Mac25 interacts with the extracellular matrix proteins and glycosaminoglycans that are expressed in most blood vessels including high endothelial venules, as well as with chemokines implicated in regulation of lymphocyte trafficking, e.g., SLC and IP-10. PMID: 12847218
    12. Proteolytic processing of mac25 modulates its insulin/IGF-1-dependent growth-stimulatory activity. PMID: 14521955
    13. IGFBP-7 can regulate glioma cell migration through the AKT-ERK pathway, thereby playing an important role in glioma growth and migration PMID: 19048112

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:29817

    UniGene: Mm.233470



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