在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Inositol polyphosphate multikinase (Ipmk)

Recombinant Mouse Inositol polyphosphate multikinase (Ipmk)

  • 中文名稱：
    小鼠Ipmk重組蛋白
  • 貨號：
    CSB-YP011774MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ipmk重組蛋白
  • 貨號：
    CSB-EP011774MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ipmk重組蛋白
  • 貨號：
    CSB-EP011774MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ipmk重組蛋白
  • 貨號：
    CSB-BP011774MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ipmk重組蛋白
  • 貨號：
    CSB-MP011774MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ipmk; Impk; Ipk2; Inositol polyphosphate multikinase; EC 2.7.1.140; EC 2.7.1.151; EC 2.7.1.153; Inositol 1,3,4,6-tetrakisphosphate 5-kinase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-396
  • 氨基酸序列
    AAEPPALRL RPPGSTGDSP PVPRLLGGCV PLSHQVAGHM YGKDKVGILQ HPDGTVLKQL QPPPRGPREL EFYTMVYAAD CADAVLLELR KHLPKYYGVW SPPTAPNDVY LKLEDVTHKF NKPCIMDVKI GRKSYDPFAS SEKIQQQVSK YPLMEEIGFL VLGMRVYHLH SDSYETQNQH YGRGLTKETL KEGVSKFFHN GFCLRKDAIA ASIQKVEKIL QWFENQKQLN FYASSLLFVY EGSSQPATTK ANDRTLAGRF LSKGPLTDAD GLECNNNFHL FGAPPNGMSV GKSLSKAYSR HRKLYAKKHQ SQTSLKVETL EQDNGWRSMS QEHLNGNVLA QLEKVFYHLP AGRPEIPEAE VRMIDFAHVF PSNTVDEGYV YGLKHLIAVL RSILDS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis. Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6).
  • 基因功能參考文獻：
    1. these findings identify IPMK as a key determinant of TRAF6 stability and elucidate the physiological function of IPMK in TLR-induced innate immunity. PMID: 28439546
    2. Data show that phospholipase C (PLC)-beta1 (PLC-beta1) overexpression determines an increase in beta-catenin translocation and that PLC-beta1, inositol polyphosphate multikinase (IPMK) and beta-catenin are mediators of the same signaling pathway. PMID: 27563828
    3. a severe loss of IPMK in the striatum of Huntington disease patients and in several cellular and animal models of the disease, is reported. PMID: 26195796
    4. metformin-mediated activation of AMP-Activated Protein Kinases was impaired in the absence of IPMK. PMID: 24877601
    5. Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes. PMID: 24248338
    6. Knockdown of expression and/or inhibition of function of phospholipase Cgamma1, inositol polyphosphate multikinase, which generates inositol 1,3,4,5-tetrakisphosphate (InsP) and InsP, and inositol hexakisphosphate kinase 1/2 PMID: 23322705
    7. Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction. PMID: 24043835
    8. IPMK regulates glucose signaling to AMPK in a pathway whereby glucose activates phosphorylation of IPMK at tyrosine 174 enabling the enzyme to bind to AMPK and regulate its activation. PMID: 22203993
    9. Data show that in MEFs lacking IPMK, synthesis of IP5 and IP7 is abolished, but IP6 formation is reduced about 90%. PMID: 21220345
    10. Inositol polyphosphate multikinase (Ipk2) plays a major role in the synthesis of inositol polyphosphate messengers derived from inositol 1,4,5-trisphosphate in embryogenesis and normal development. PMID: 15939867

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Inositol phosphokinase (IPK) family
  • 數據庫鏈接：


主站蜘蛛池模板： 日韩人妻无码精品免费shipin| 日本特黄特色aaa大片免费| 亚洲精品无码永久在线观看性色| 国产精品成人久久电影| 女人裸体性做爰视频| 中文字幕日产熟女乱码| 无码人妻丝袜在线视频红杏| 欧洲av无码放荡人妇网站| 日本乱人伦在线观看| 西西人体扒开下部试看120秒| 性xxxxx欧美极品少妇| 免费无码又爽又刺激聊天app| 精品少妇人妻av无码久久| 国产成人精品成人a在线观看| 久久99精品久久久久久清纯| 国产精品久久毛片| 国产免费无遮挡吸奶头视频| 男女车车的车车网站w98免费| 真实国产乱子伦在线视频| 精品少妇爆乳无码av无码专区| 成av免费大片黄在线观看| 亚洲人成网亚洲欧洲无码久久 | 777米奇色狠狠俺去啦| 国产精品av在线| 国产av天堂无码一区二区三区 | 国产成人免费高清直播| 欧美日产国产精品| 人妻少妇被猛烈进入中文字幕| 亚洲一区波多野结衣在线| 在线观看免费视频网站a站| 天美传媒一区二区| 无码人妻丰满熟妇区毛片18| 亚洲一区爱区精品无码| 亚洲人成人网站在线观看| 人妻少妇精品无码专区二区| av无码人妻无码男人的天堂| 伊人久久大香线蕉av五月天| 看免费真人视频网站| 国内揄拍国内精品对白86| 免费又黄又爽又猛的毛片| 婷婷亚洲综合五月天小说|