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  4. Recombinant Mouse Hypoxia-inducible lipid droplet-associated protein (Hilpda), partial

Recombinant Mouse Hypoxia-inducible lipid droplet-associated protein (Hilpda), partial

  • 中文名稱：
    小鼠Hilpda重組蛋白
  • 貨號：
    CSB-YP864370MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hilpda重組蛋白
  • 貨號：
    CSB-EP864370MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hilpda重組蛋白
  • 貨號：
    CSB-EP864370MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hilpda重組蛋白
  • 貨號：
    CSB-BP864370MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hilpda重組蛋白
  • 貨號：
    CSB-MP864370MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hilpda
  • Uniprot No.：
  • 別名：
    Hilpda; Hig2; Hypoxia-inducible lipid droplet-associated protein; Hypoxia-inducible gene 2 protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
  • 基因功能參考文獻：
    1. Authors conclude that Hig2 localizes to LDs in adipocytes, promoting adipose tissue lipid deposition and that its selective deficiency in active brown/beige adipose tissue mediates improved glucose tolerance at 23 degrees C. PMID: 27900258
    2. Thus, macrophage Hilpda is crucial to foam-cell formation and lipid deposition, and to controlled prostaglandin-E2 production. By these means Hilpda promotes lesion formation and progression of atherosclerosis PMID: 28760743
    3. HILPDA is highly abundant in adipose tissue, where its levels are induced by peroxisome proliferator-activated receptor gamma and beta-adrenergic stimulation. In contrast to the reported inhibition of lipolysis by HILPDA in hepatocytes, those data do not support an important direct role of HILPDA in the regulation of lipolysis in adipocytes in vivo and in vitro. PMID: 28323980
    4. When fasted, HILPDA KO mice are unable to maintain body temperature and become hypothermic at 22 degrees C. PMID: 28739822
    5. data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion. PMID: 24876382
    6. HIG2 was up-regulated by hypoxia and HIF inducers in all cell types and mouse organs investigated and abundantly expressed in renal clear-cell carcinomas PMID: 20624928

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  • 亞細胞定位：
    Lipid droplet. Secreted. Membrane; Single-pass membrane protein.
  • 數據庫鏈接：

    KEGG: mmu:69573

    UniGene: Mm.45161



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