在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Hypoxia-inducible factor 3-alpha (Hif3a)

Recombinant Mouse Hypoxia-inducible factor 3-alpha (Hif3a)

  • 中文名稱：
    小鼠Hif3a重組蛋白
  • 貨號：
    CSB-YP613122MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hif3a重組蛋白
  • 貨號：
    CSB-EP613122MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hif3a重組蛋白
  • 貨號：
    CSB-EP613122MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hif3a重組蛋白
  • 貨號：
    CSB-BP613122MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hif3a重組蛋白
  • 貨號：
    CSB-MP613122MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hif3a
  • Uniprot No.：
  • 別名：
    Hif3a; Mop7; NepasHypoxia-inducible factor 3-alpha; HIF-3-alpha; HIF3-alpha; Basic-helix-loop-helix-PAS protein MOP7; HIF3-alpha-1; Inhibitory PAS domain protein; IPAS; Member of PAS protein 7; Neonatal and embryonic PAS protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-662
  • 氨基酸序列
    MDWDQDRSNT ELRKEKSRDA ARSRRSQETE VLYQLAHTLP FARGVSAHLD KASIMRLTIS YLRMHRLCAA GEWNQVEKGG EPLDACYLKA LEGFVMVLTA EGDMAYLSEN VSKHLGLSQL ELIGHSIFDF IHPCDQEELQ DALTPRPNLS KKKLEAPTER HFSLRMKSTL TSRGRTLNLK AATWKVLHCS GHMRAYKPPA QTSPAGSPRS EPPLQCLVLI CEAIPHPASL EPPLGRGAFL SRHSLDMKFT YCDERIAEVA GYSPDDLIGC SAYEYIHALD SDAVSRSIHT LLSKGQAVTG QYRFLARTGG YLWTQTQATV VSGGRGPQSE SIICVHFLIS RVEETGVVLS LEQTEQHTRR PPRLSASSQK GIPGNSVDSP APRILAFLHP PALSEASLAA DPRRFCSPDL RRLMAPILDG PPPAATPSTP QATRRPQSPL PADLPDKLTV GLENAHRLST AQKNKTVETD LDIAQDPDTL DLEMLAPYIS MDDDFQLNSS EQLPKVHRRP PRVARRPRAR SFHGLSPPIP EPSLLPRWGS DPRLNCSSPS RGDRPTASLM PGTRKRALAQ SSEDKGLELL ETKPPKRSPR LEPGSFLLPP LSLSFLLQGR QLPGNQQDPR APLVHSHEPL GLAPSLLSLC QHEETVQPRN RFPPAAGLGQ TH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression. Plays a role in the development of the cardiorespiratory system.; Acts as positive regulator of hypoxia-inducible gene expression. Associates to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters in a ARNT-dependent manner, and hence also participates in the transcriptional activation of reporter genes driven by HRE.; Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. May act as a tumor suppressor. May also be involved in apoptosis.; Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Plays also a role in the development of the lung and heart during embryonic and neonatal stages.
  • 基因功能參考文獻：
    1. Phosphorylation of inhibitory PAS domain protein (IPAS) at Ser184 by MAPK-activated protein kinase 2 (MK2 or MAPKAPK2) enhances the proapoptotic function of IPAS. PMID: 29054108
    2. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a PMID: 25847716
    3. mRNA of HIF-2alpha and Ets-1 were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin gene. PMID: 25626335
    4. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf in bone, which explain, at least in part, the small body size of Tnni2K175del mice PMID: 25340332
    5. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha and HIF-3alpha expression. PMID: 21338581
    6. It is a negative regulator of tumorigenesis.(review) PMID: 21404626
    7. alternative splicing and expression of IPAS is induced by hypoxia. PMID: 12119283
    8. These data suggest an involvement of the HIF system in metabolic derangements as for instance caused by diabetes. PMID: 17125738
    9. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling. PMID: 18070924
    10. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta. PMID: 9840812

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.; [Isoform 2]: Nucleus. Cytoplasm. Nucleus speckle. Mitochondrion.
  • 組織特異性：
    Isoform 3 is expressed in endothelial cells of vessels and capillaries in alveoli of the neonatal lung (at protein level). Expressed in lung, brain, heart and kidney. Isoform 2 is expressed in heart and lung. Isoform 2 is highly expressed in the epithelia
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲色偷偷偷网站色偷一区| 欧美大肥婆大肥bbbbb| 青草伊人久久综在合线亚洲观看| 五月综合缴情婷婷六月| 精品综合久久久久久8888| 久久人人爽天天玩人人妻精品 | 92国产精品午夜福利无毒不卡| 欧美18videosex性欧美黑吊| 亚洲亚洲人成网站网址| 狠狠久久噜噜熟女| 粉嫩小泬视频无码视频软件| 欧美毛多水多肥妇| 久久国产精品99国产精| 亚洲色在线v中文字幕| 日韩欧美国产一区精品| 豆国产95在线 | 亚洲| 欧美大屁股xxxx高跟欧美黑人 | 亚洲一线产区二线产区分布| 国模杨依粉嫩蝴蝶150p| 天码av无码一区二区三区四区| 中文字幕av久久激情亚洲精品 | 中国女人内谢69xxxxxa片| 久久精品国产亚洲夜色av网站| 蜜臀少妇人妻在线| 99久久久精品免费观看国产| 隔壁老王国产在线精品| 中文字幕精品av一区二区五区| 亚洲人成网站在小说| 波多野结衣av手机在线观看 | 国语国产精精品国产国语清晰对话| av无码人妻无码男人的天堂| 欧美成人www免费全部网站| 胸大美女又黄的网站| 久久久久无码精品亚洲日韩| 无遮挡激情视频国产在线观看 | 精品亚洲成a人在线观看青青| 欧洲精品卡一卡二卡三| 亚洲日韩中文字幕一区| 色综合色狠狠天天综合网| 成人做爰www网站视频下载| 天躁夜夜躁狼狠躁|