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  4. Recombinant Mouse Homeobox protein Hox-D13 (Hoxd13)

Recombinant Mouse Homeobox protein Hox-D13 (Hoxd13)

  • 中文名稱：
    小鼠Hoxd13重組蛋白
  • 貨號：
    CSB-YP010685MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hoxd13重組蛋白
  • 貨號：
    CSB-EP010685MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hoxd13重組蛋白
  • 貨號：
    CSB-EP010685MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hoxd13重組蛋白
  • 貨號：
    CSB-BP010685MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hoxd13重組蛋白
  • 貨號：
    CSB-MP010685MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxd13
  • Uniprot No.：
  • 別名：
    Hoxd13; Hox-4.8Homeobox protein Hox-D13; Homeobox protein Hox-4.8
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-339
  • 氨基酸序列
    MSRSGTWDMD GLRADGGAAG AAPASSSSSV AAPGQCRGFL SAPVFAGTHS GRAAAAAAAA AAAAAAASSF AYPGTSERTG SSSSSSSSAV IATRPEAPVA KECPAPAAAA TAAAPPGAPA LGYGYHFGNG YYSCRMSHGV GLQQNALKSS PHASLGGFPV EKYMDVSGLA SSSVPTNEVP ARAKEVSFYQ GYTSPYQHVP GYIDMVSTFG SGEPRHEAYI SMEGYQSWTL ANGWNSQVYC AKDQPQGSHF WKSSFPGDVA LNQPDMCVYR RGRKKRVPYT KLQLKELENE YAINKFINKD KRRRISAATN LSERQVTIWF QNRRVKDKKI VSKLKDTVS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能參考文獻：
    1. The age-associated accumulation of somatic mutations that occurs in the Nup98-HOXD13 (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR transgene. PMID: 26202421
    2. study elucidated the mechanism underlying a novel missense mutation in HOXD13 (Q317K) associated with a complex hand and foot malformation phenotype; results show that the mutation results in a shift in the binding profile of the mutant toward a bicoid/PITX1 motif PMID: 23995701
    3. providing synpolydactyly limb explant cultures with cells expressing either HOXD13 or WNT5A led to a non-cell autonomous partial rescue of cell polarity the perichondral region and restored the expression of perichondral markers. PMID: 24161848
    4. a slight and transient deregulation of Hoxd13 expression can readily affect the relative lengths of limb segments during development PMID: 22374744
    5. expression of NHD13 fusion gene resulted in impaired NHEJ-mediated DNA break repair. PMID: 23131583
    6. Anterior-posterior differences in HoxD chromatin topology in limb development. PMID: 22872084
    7. findings show that expression of NUP98-HOXD13 impairs class switch recombination and reduces the antibody-mediated immune response, in addition to its role in leukemia PMID: 22613470
    8. Mice expressing both the FLT3/ITD and Nup98-HoxD13 (NHD13) fusion gene developed acute myeloid leukemia with 100% penetrance PMID: 22323452
    9. Genetic analysis of the Dyc mutant revealed a trinucleotide expansion in the polyalanine-encoding region of the Hoxd13 gene resulting in a 7-alanine expansion, responsible for fork stalling and template switching. PMID: 19546318
    10. The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements PMID: 11850178
    11. NUP98-HOXD13 promoted growth and impaired differentiation of hematopoietic progenitor cells; transplantation of bone marrow cells cotransduced with NUP98-HOXD13 and the HOX cofactor Meis1 rapidly caused lethal and transplantable acute myeloid leukemia PMID: 12543865
    12. a HOXD13 homeodomain is not necessary for posterior prevalence in mouse limb development PMID: 16806154
    13. Replacement of the wild-type Hoxd-13 gene with one lacking the 15-residue polyalanine tract affected sesamoid bone formation in knock-in mice. PMID: 17065594
    14. The onset of leukemia was accelerated, suggesting a synergistic effect between the NUP98-HOXD13 transgene and the genes neighboring retroviral insertion events. PMID: 17545593
    15. Hoxd13 binds in vivo and regulates the expression of genes acting in key pathways for early limb and skeletal patterning. PMID: 18407260
    16. Results suggest that mutated Hoxd13 causes polydactyly in synpolydactyly by inducing extraneous interdigital chondrogenesis, both directly and indirectly, via a reduction in retinoic acid levels. PMID: 19075394
    17. The expression of the NUP98-HOXD13 fusion transgene inhibits lymphoid as well as myeloid and erythroid differentiation, results in overexpression of Hoxa cluster genes, and leads to a precursor T cell lymphoblastic leukemia/lymphoma. PMID: 19841179

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 數據庫鏈接：


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