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  4. Recombinant Mouse Homeobox protein Hox-A2 (Hoxa2)

Recombinant Mouse Homeobox protein Hox-A2 (Hoxa2)

  • 中文名稱：
    小鼠Hoxa2重組蛋白
  • 貨號：
    CSB-YP010652MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hoxa2重組蛋白
  • 貨號：
    CSB-EP010652MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hoxa2重組蛋白
  • 貨號：
    CSB-EP010652MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hoxa2重組蛋白
  • 貨號：
    CSB-BP010652MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hoxa2重組蛋白
  • 貨號：
    CSB-MP010652MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxa2
  • Uniprot No.：
  • 別名：
    Hoxa2; Hox-1.11; Hoxa-2Homeobox protein Hox-A2; Homeobox protein Hox-1.11; Hox1.11
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-372
  • 氨基酸序列
    MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI SADSFDFFTD TLTTIDLQHL NY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能參考文獻：
    1. These results establish a role for Hox factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit. PMID: 28052248
    2. our data support that KPC2 regulates Hoxa2 by promoting its relocation to the cytoplasm. PMID: 26303204
    3. Ectopic Hoxa2 expression results in the transformation of the proximal Meckel's cartilage and the malleus into a supernumerary styloid process (SP), a second pharyngeal arch-derived mammalian-specific skeletal structure. PMID: 25889273
    4. Hoxa2 operates as a tissue-specific cofactor, enhancing Meis binding to specific sites that provide the second arch with its anatomical identity PMID: 25640223
    5. The impairment of chondrogenic differentiation by Hoxa2 overexpression. PMID: 24129174
    6. Data show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch. PMID: 23671666
    7. Hoxa2 partly controls the morphogenesis of the pinna through the BMP signalling pathway and expression of Eya1, which in humans is involved in branchio-oto-renal syndrome. PMID: 24067355
    8. Hoxb2 antagonizes Hoxa2 during rostral hindbrain oligodendrogenesis. PMID: 23197710
    9. the sustained expression of Hoxa2 in the chondrocyte lineage is characterized by a proportionate short stature resulting from skeletal growth defect. PMID: 22093256
    10. The data reveals that Hoxa2 has large genome coverage and potentially regulates thousands of genes. PMID: 22223247
    11. The inhibition of miR-3960 expression attenuated the osteoblastogenesis. Homeobox A2 (Hoxa2), a repressor of Runx2 expression, was confirmed to be a target of miR-3960. PMID: 21324897
    12. Meox1 expression is downregulated in the second arch of Hoxa2 mouse mutant embryos. PMID: 21245383
    13. The Satb2 gene was down-regulated and the Hoxa2 gene was up-regulated in phenytoin-treated mouse embryonic craniofacial tissue. PMID: 20651846
    14. Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element PMID: 15033486
    15. although Hoxa2 is expressed throughout oligodendrocyte development, it does not appear to be critical for early stages of oligodendrogenesis in the murine spinal cord PMID: 15326611
    16. Hoxa2 regulation of Six2 is confined to a 0.9 kb fragment of the Six2 promoter and that Hoxa2 binds to this promoter region PMID: 15634706
    17. Hoxa2 is selectively required in cranial neural crest cells (NCCs) PMID: 16221728
    18. Hoxa2- and rhombomere 3-dependent cues determine the whisker area map and are required for the assembly of the whisker-to-barrel somatosensory circuit PMID: 16902088
    19. Hoxa2 displays an anti-chondrogenic activity that is distinct from its patterning function PMID: 17359301
    20. Lmo1 takes part in a Hox paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning PMID: 17676642
    21. Hoxa2-/- mutation leads to the elimination of a transient control of the inspiratory amplitude normally occurring during the first hours following birth. PMID: 17897445
    22. Hox genes control the neurogenic potential of at least some cranial neural crest cells. PMID: 18164701
    23. propose that Six2 acts to mediate Hoxa2 control over the insulin-like growth factor pathway during branchial arch development PMID: 18321982
    24. Results demonstrate the cleft palate phenotype of Hoxa2 null embryos is not solely due to abnormal tongue musculature, and indicate a direct role of Hoxa2 in regulating murine palatogenesis. PMID: 19653318

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Proboscipedia subfamily
  • 數據庫鏈接：

    KEGG: mmu:15399

    STRING: 10090.ENSMUSP00000014848

    UniGene: Mm.131



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