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  4. Recombinant Mouse Homeobox protein Hox-A11 (Hoxa11)

Recombinant Mouse Homeobox protein Hox-A11 (Hoxa11)

  • 中文名稱：
    小鼠Hoxa11重組蛋白
  • 貨號：
    CSB-YP010649MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hoxa11重組蛋白
  • 貨號：
    CSB-EP010649MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hoxa11重組蛋白
  • 貨號：
    CSB-EP010649MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hoxa11重組蛋白
  • 貨號：
    CSB-BP010649MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hoxa11重組蛋白
  • 貨號：
    CSB-MP010649MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxa11
  • Uniprot No.：
  • 別名：
    Hoxa11; Hox-1.9; Hoxa-11; Homeobox protein Hox-A11; Homeobox protein Hox-1.9
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-313
  • 氨基酸序列
    MMDFDERGPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS NLPQVQPVRE VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA AGVPGDVLAK SSANVYHHPT PAVSSNFYST VGRNGVLPQA FDQFFETAYG TPENLASSDY PGDKNAEKGP QAAAATSAAA VAAAATGAPA TSSSDGGGGG GCQEAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSGGQR TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN RDRLQYYSAN PLL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能參考文獻：
    1. the derived functional cooperativity between HOXA11 and FOXO1 is due to derived allosteric regulation of HOXA11 by FOXO1. PMID: 27239043
    2. On the basis of the polydactyly that we observed after expression of Hoxa11 in distal limbs, we propose that the evolution of Hoxa11 regulation contributed to the transition from polydactyl limbs in stem-group tetrapods to pentadactyl limbs in extant tetrapods. PMID: 27706137
    3. Shox2 expression restricted to the proximal limb along with Hoxd9 and Hoxa11 expression, juxtaposing the distal expression of Hoxa13 and Hoxd13. PMID: 25217052
    4. Hoxa-11 maintains cell proliferation in the mouse gubernaculum to facilitate testicular descent. PMID: 24314182
    5. Results reveal that Hoxa11 knockdown in the uterosacral ligaments and uterus increases extracellular matrix degradation. PMID: 22190701
    6. Hox11 genes (Hoxa11, Hoxc11 and Hoxd11) co-regulate and coordinate the development of zeugopod skeletal elements and adjacent elbow and knee joints, and dictate joint identity, morphogenesis and anatomical and functional organization. PMID: 20978074
    7. mice individually mutant for Hoxa11 or Hoxd11 show no discernible kidney abnormalities. Hoxa11/Hoxd11 double mutants, however, demonstrate hypoplasia of the kidneys PMID: 12050119
    8. Hoxa11 is required for proper cellular proliferation and apoptotic responses in the developing neonatal uterus. PMID: 14551265
    9. malformation of the forelimb zeugopod in Hoxa11/Hoxd11 double mutants is a consequence of interruption at multiple steps during the formation of the radius and ulna PMID: 14668414
    10. Hoxa-11 and Hoxa-13 are involved in the negative regulation of MyoD expression in limb muscle precursors PMID: 14706073
    11. identify the multiple molecular pathways downstream of Hoxa11/Hoxd11 function in the developing kidney PMID: 16581055
    12. Yin Yang 1 represses Hoxa11-dependent transcription via interactions with the Hox proteins and Histone Deacetylase recruitment PMID: 16963455
    13. HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. PMID: 18274672
    14. mice mutant for Hoxd11 and Hoxa11 show absence of radius and ulna, anterior homeotic transformation of vertebra, and severe kidney defects, suggesting Hoxd11 and Hoxa11 act together to specify limb outgrowth and patterning of proximodistal axis PMID: 7596412

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 數據庫鏈接：


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