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  4. Recombinant Mouse Homeobox protein DLX-3 (Dlx3)

Recombinant Mouse Homeobox protein DLX-3 (Dlx3)

  • 中文名稱：
    小鼠Dlx3重組蛋白
  • 貨號：
    CSB-YP720656MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Dlx3重組蛋白
  • 貨號：
    CSB-EP720656MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Dlx3重組蛋白
  • 貨號：
    CSB-EP720656MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Dlx3重組蛋白
  • 貨號：
    CSB-BP720656MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Dlx3重組蛋白
  • 貨號：
    CSB-MP720656MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Dlx3
  • Uniprot No.：
  • 別名：
    Dlx3Homeobox protein DLX-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-287
  • 氨基酸序列
    MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY YSGQPYGQTV NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE QPLPAQDPVS VKEEPEAEVR MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK AQYLALPERA ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEVPLEHSPN NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS PNYLDDPTNS WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
  • 基因功能參考文獻：
    1. DLX3 is indispensable for the regulation of ion transporters and carbonic anhydrases during the maturation stage of amelogenesis, exerting a crucial regulatory function on pH oscillations during enamel mineralization. PMID: 27760456
    2. ER-alpha regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3. PMID: 26674964
    3. indicate that Distal-less-3 negatively regulates osteoclastic differentiation through microRNA-124 PMID: 26836061
    4. our data show that DLX3 promotes the expression of the EMP genes Amelx, Enam, Klk4, and Odam in amelogenesis. PMID: 25815730
    5. Results suggest that Dlx3 is a novel target of PKA, and that PKA mediates BMP signaling during osteoblast differentiation, at least in part, by phosphorylating Dlx3 and modulating its stability and function. PMID: 24924519
    6. The DLX3 regulates transcription factors crucial for bone formation and DLX3 attenuates bone mass accrual to support bone homeostasis by osteogenic gene pathway regulation. PMID: 24948010
    7. We show that the deletion of Dlx3 in epidermis and isthums/infundibulum area leads to hair shaft differentiation but not hair growth. PMID: 25120002
    8. we provide a novel insight that BMP-2-induced Dlx3 expression is regulated by p38/Smad5 signaling pathway in osteoblasts. PMID: 24647893
    9. used a conditional knockout approach to analyze the effects of neural crest deletion of Dlx3 on craniofacial bones development PMID: 22886599
    10. regulation of Dlx3 by HR affects the IRS keratin expression, thus modulating the formation of IRS of hair follicle. PMID: 22442153
    11. The transcription factor Dlx3 is essential in dentin formation by directly regulating a crucial matrix protein. PMID: 22351765
    12. Dlx3 ablation in epidermis is linked to altered epidermal differentiation, barrier development, and IL-17-associated skin inflammation. PMID: 21709238
    13. Mutant Dlx3 disrupts odontoblast polarization and dentin formation. PMID: 20510228
    14. AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
    15. Genomic structure and functional control of the Dlx3-7 bigene cluster PMID: 11792834
    16. Gene expression regulation of this protein in visceral arches is evolutionarily conserved. PMID: 12642674
    17. Results describe gene regulation by Dlx3 in relation to that of Msx2 and Dlx5 during osteoblast differentiation. PMID: 15456894
    18. DLX3 is one of 3 homeodomain proteins that provide a key series of molecular switches that regulate expression of Runx2 throughout bone formation. PMID: 17060321
    19. Dlx3 is sufficient to directly modulate expression of the Placental growth factor gene promoter in placental cells. PMID: 17110422
    20. DLX3 mutation also accelerates the differentiation of osteoprogenitor cells to osteoblasts at later stages of osteogenesis PMID: 17950683
    21. Dlx3 is a crucial regulator of hair follicle differentiation and cycling. PMID: 18684741
    22. These data suggest a novel role for this DLX-3 mutation in osteoclast differentiation and bone resorption. PMID: 18996110

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Distal-less homeobox family
  • 組織特異性：
    Not expressed in the central nervous system. Expressed in a highly restricted region of the branchial arches. In later development, expressed in the developing middle and inner ear, teeth and whisker follicles.
  • 數據庫鏈接：


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