在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Histone deacetylase 8 (Hdac8)

Recombinant Mouse Histone deacetylase 8 (Hdac8)

  • 中文名稱：
    小鼠Hdac8重組蛋白
  • 貨號：
    CSB-YP010244MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hdac8重組蛋白
  • 貨號：
    CSB-EP010244MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hdac8重組蛋白
  • 貨號：
    CSB-EP010244MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hdac8重組蛋白
  • 貨號：
    CSB-BP010244MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hdac8重組蛋白
  • 貨號：
    CSB-MP010244MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Hdac8; Histone deacetylase 8; HD8; EC 3.5.1.98
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-377
  • 氨基酸序列
    MEMPEEPANS GHSLPPVYIY SPEYVSICDS LVKVPKRASM VHSLIEAYAL HKQMRIVKPK VASMEEMATF HTDAYLQHLQ KVSQEGDEDH PDSIEYGLGY DCPATEGIFD YAAAIGGGTI TAAQCLIDGK CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFD RILYVDLDLH HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDMSDVGLG KGRYYSVNVP IQDGIQDEKY YHICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY VLQWQLATLI LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH RIQQILNYIK GNLKHVV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
  • 基因功能參考文獻：
    1. The activity of HDAC2 and HDAC8 was elevated 7 days after the ischemia both in neurons and astrocytes of the studied brain structures. PMID: 29218547
    2. HDAC8 regulates neural differentiation by exerting control of embryoid body formation. PMID: 29499194
    3. Results indicate that HDAC8 functions to modulate p53 activity to ensure long-term hematopoietic stem cells (LT-HSCs) maintenance and cell survival under stress. PMID: 29084772
    4. The findings suggest that miR-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 acetylation. PMID: 27638301
    5. this study demonstrates a novel role of HDAC8 in LeTx immunotoxicity and regulation of pro-IL-1beta production likely through eRNAs. PMID: 26912657
    6. HDAC8i induced cell growth inhibition and marked S-phase cell cycle arrest in human and murine-derived MPNST cells PMID: 26200462
    7. findings show how HDAC8 drives nonalcoholic fatty liver disease-associated hepatocarcinogenesis PMID: 26383163
    8. Data reveal a role for miR-21-3p in regulating HDAC8 expression and Akt/Gsk3beta pathway in cardiac hypertrophy. PMID: 25504627
    9. histone deacetylase 8 inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo PMID: 25451941
    10. HDAC8 and Sirt1 were also demonstrated to interact directly with ERRalpha in vivo and to deacetylate and increase the DNA binding affinity of ERRalpha in vitro. PMID: 20484414
    11. Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, and deletion of Hdac8 in cranial neural crest cells and Hdac8 specifically represses the aberrant expression of homeobox transcription factors such as Otx2 and Lhx1 PMID: 19605684

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Histone deacetylase family, HD type 1 subfamily
  • 數據庫鏈接：


主站蜘蛛池模板： 国产v在线最新观看视频| 国产无套粉嫩白浆在线观看| 在线精品自偷自拍无码中文| 国产成人无码一区二区三区| 女人下边被添全过视频的网址| 中文字幕av无码不卡| 97超碰精品成人国产| 男女免费观看做爰视频在线观看 | www一区二区乱码www| aⅴ亚洲 日韩 色 图网站 播放| 欧美牲交a欧美牲交aⅴ一| 内射毛片内射国产夫妻| av一区二区三区人妻少妇| 精品av一区二区久久久| 伊人久久大香线蕉av网| 无码丰满熟妇juliaann与黑人| 日日干夜夜干| 国产未发育呦交视频| 97精品免费公开在线视频| 国产欧美亚洲日韩图片| av免费不卡国产观看| 波多野42部无码喷潮| 永久免费男同av无码入口| 色综合a怡红院怡红院| 无码国产一区二区免费| 亚洲精品一线二线三线无人区| 精品国产午夜肉伦伦影院| 欧美综合自拍亚洲图久青草| 日本肉体裸xxxxbbbb| 国产av无码国产av毛片| 亚洲欧美丝袜精品久久| 欧美xxxx狂喷水| 亚洲大码熟女在线观看| 热re99久久精品国产99热| 国产乱人伦偷精品视频| 午夜高清在线无码| 色欲天天天天天综合网| 亚洲成a人v欧美综合天堂| 婷婷国产成人精品视频| 国产99视频精品免费视频36| 爽到高潮无码视频在线观看|