在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Harmonin (Ush1c), partial

Recombinant Mouse Harmonin (Ush1c), partial

  • 中文名稱：
    小鼠Ush1c重組蛋白
  • 貨號：
    CSB-YP875361MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ush1c重組蛋白
  • 貨號：
    CSB-EP875361MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ush1c重組蛋白
  • 貨號：
    CSB-EP875361MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ush1c重組蛋白
  • 貨號：
    CSB-BP875361MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ush1c重組蛋白
  • 貨號：
    CSB-MP875361MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ush1c
  • Uniprot No.：
  • 別名：
    Ush1c; Harmonin; PDZ domain-containing protein; Usher syndrome type-1C protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips.
  • 基因功能參考文獻(xiàn)：
    1. under normal housing conditions, Ush1g(-/-) and Ush1c(-/-) albino mice have dysfunctional cone photoreceptors whereas pigmented knockout animals have normal photoreceptors. PMID: 29386551
    2. Harmonin enhances voltage-dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cells. PMID: 23613530
    3. MYO7A, USH1G (Sans) and CDH23 form the upper tip-link complex in adult mice, likely in combination with USH1C (harmonin). PMID: 22381527
    4. examine the effects of null mutation of the Ush1c gene on subcellular localization of Myo7a, Pcdh15 and Sans in the inner ear PMID: 21156003
    5. Cadherin-23, myosin VIIa and harmonin form a ternary complex and interact with phospholipids. PMID: 20639393
    6. The fact that Ush1c expression is much higher in the ear than in the eye suggests a different role for Ush1c in ear function than in the eye and may explain why Ush1c mutant mice do not recapitulate vision defects. PMID: 20211154
    7. forms a complex with cadherin 23 by means of PDZ-domain interactions PMID: 12407180
    8. the shaping of the hair bundle relies on a functional unit composed of myosin VIIa, harmonin b and cadherin 23 that is essential to ensure the cohesion of the stereocilia PMID: 12485990
    9. Rac-DOCK4-actin-binding protein harmonin-activated signaling pathway is possibly involved in regulating actin cytoskeleton organization in stereocilia of the inner ear. PMID: 16464467
    10. Homozygous Ush1c216A (216AA) mice are hyperactive, display circling and head tossing behavior, and do not have a Preyer reflex at 21-25 days old. PMID: 17174357
    11. harmonin is a upper tip-link density component and contributes to establishing the sensitivity of mechanotransduction channels to displacement. PMID: 19447093
    12. harmonin-b operates as an intracellular link that limits adaptation and engages adaptation motors PMID: 19756723

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, microvillus.
  • 組織特異性：
    Detected in stereocilia of cochlear hair cells (at protein level). Isoform 1 is expressed in the eye, cochlea, vestibule, heart, kidney, small intestine and testis; it is barely visible in skeletal muscle, liver, and lung and is absent from the brain. Iso
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 日韩去日本高清在线| 亚洲欧洲日产国码无码av一| 高清欧美性猛交xxxx黑人猛交| 一本一道av中文字幕无码| 邪恶肉肉全彩色无遮盖| 日产精品久久久久久久性色| 四虎成人精品国产永久免费无码| 国产精品国产亚洲区艳妇糸列短篇| 精品熟女少妇av久久免费软件| www夜片内射视频在观看视频| 使劲快高潮了国语对白在线| 曰本无码不卡高清av一二| 天天av天天av天天透| 国产热re99久久6国产精品首页| 少妇荡乳情欲办公室456视频| 亚洲日韩欧洲无码av夜夜摸| 国产成人精品999视频| 国内精品久久久久久tv| 黑人巨茎大战俄罗斯美女| 美女扒开奶罩露出奶头视频网站 | 鲁大师在线视频播放免费观看| 亚洲熟女综合一区二区三区| 国产av毛片亚洲含羞草社| 亚洲精品国偷拍自产在线麻豆| 波多野结衣在线精品视频| 久久婷婷五月综合色首页| 强行征服邻居人妻淑敏| 丰满的少妇xxxxx青青青| 国产成人精品福利网站| 成人啪精品视频网站午夜| 新版天堂资源中文8在线| 亚洲精品成人无限看| 欧美乱码伦视频免费| 亚洲成 人 综合 亚洲欧洲| 亚洲日韩成人无码| 1区2区3区高清视频| 日韩亚洲国产中文永久| 中国女人做爰视频| 日产精品一区2区卡四卡二卡| 国产精品久久国产精麻豆99网站 | 人妻激情偷乱视频一区二区三区|