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  4. Recombinant Mouse H2.0-like homeobox protein (Hlx)

Recombinant Mouse H2.0-like homeobox protein (Hlx)

  • 中文名稱：
    小鼠Hlx重組蛋白
  • 貨號：
    CSB-YP720257MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hlx重組蛋白
  • 貨號：
    CSB-EP720257MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hlx重組蛋白
  • 貨號：
    CSB-EP720257MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hlx重組蛋白
  • 貨號：
    CSB-BP720257MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hlx重組蛋白
  • 貨號：
    CSB-MP720257MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hlx
  • Uniprot No.：
  • 別名：
    Hlx; Hlx1H2.0-like homeobox protein; Homeobox protein HLX1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-476
  • 氨基酸序列
    MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL HAGVGEPGPA AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP SEVPAGFPQR LSPLSAAFHQ HLPQQSPTQQ QQPQQQPPPP PRAVSLQPPT SGTRVVPHHS GSAPAPSSKD LKFGIDRILS AEFDPKVKEG NTLRDLTSLL TGGRPAGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN PRNSVQHQFQ DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG GVPAEGEREE RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT TVIKASAAGA LITASSSTSG SSFSFSSTSS LGSGNTHVGS ASSLGGNCSE LPSAHQPSVT SSPQSPEIAQ APLAGL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.
  • 基因功能參考文獻：
    1. HLX is a homeobox transcription factor gene which is relatively conserved across species. Hlx homozygous null mice have a short bowel and reduced muscle cells in the diaphragm, closely resembling the anomalies in the two fetuses and we therefore suggest that the HLX mutation in this family could explain the fetal findings PMID: 28898547
    2. Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. PMID: 28701693
    3. methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx. PMID: 24934598
    4. Hlx regulates sprouting in vitro, but its role in sprouting is nonessential in vivo. HLX is regulated by shear stress and a subtle defect in vascular remodeling is present in knockout embryos. PMID: 24764455
    5. Results shown that over-expressed Hlx in DC2.4 up-regulated the transcription and expression of IFN-gamma, increased the expression of maturation makers including CD40, CD80, CD86, MHC-I and MHC-II PMID: 22483852
    6. Transient over-expression of Hlx in DC2.4 promotes DC2.4 maturation and up-regulates IL-12, IL-10 and TGF-beta expression. H1x modified DC2.4 cells seem to function as regulatory dendritic cells PMID: 21419047
    7. Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of interferon-gamma PMID: 17110450

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    H2.0 homeobox family
  • 組織特異性：
    Expressed in Th1 cells, CD8-positive T-cells, B-cells and NK cells.
  • 數據庫鏈接：


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