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  4. Recombinant Mouse H-2 class II histocompatibility antigen, A beta chain (H2-Ab1), partial

Recombinant Mouse H-2 class II histocompatibility antigen, A beta chain (H2-Ab1), partial

  • 中文名稱：
    小鼠H2-Ab1重組蛋白
  • 貨號：
    CSB-YP320377MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠H2-Ab1重組蛋白
  • 貨號：
    CSB-EP320377MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠H2-Ab1重組蛋白
  • 貨號：
    CSB-EP320377MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠H2-Ab1重組蛋白
  • 貨號：
    CSB-BP320377MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠H2-Ab1重組蛋白
  • 貨號：
    CSB-MP320377MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    H2-Ab1
  • Uniprot No.：
  • 別名：
    A beta chain; H-2 class II histocompatibility antigen; H2 Ab1; H2 I A beta; H2-Ab1; HB2A_MOUSE; Histocompatibility 2 class II antigen A beta 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. Both the modest nature of the TLR2-mediated inflammatory response and the modulation of MHC-II expression by Brucella abortus may contribute to bacterial survival in alveolar macrophages. PMID: 24478078
    2. Murine CD4+ T cells specific for Salmonella peptide/class II histocompatibility ligands are numerically stable for more than a year after initial oral infection with Salmonella. PMID: 23382562
    3. T helper cells with captured peptide-MHC-II (H2-Ab1) antigen molecules become effector cells that manifest better recall responses, and regulatory (Treg) cells with captured ligands exhibit enhanced suppression activity. PMID: 21242518
    4. Data demonstrate that the presence of distinct forms of MHC-II with plasma membrane lipid rafts is required for MHC-II aggregation in APCs. PMID: 20833718
    5. MHC II (I-A) molecules may indirectly effect TCR contacts with a peptide and drive functionally distinct immune responses. PMID: 11985705
    6. crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution PMID: 12589760
    7. An abundant autologous peptide derived from processing of the I-A(k) beta-chain has been isolated from B cell lines where it was found in high abundance; it was also present in lines lacking HLA-DM, but in considerably lower amounts. PMID: 12682247
    8. NOD mice beta cells express I-A(g7) and could be a direct target of autoreactive CD4+ T cells (I-A(g7)) PMID: 12856083
    9. IAbeta has a role in autoimmune cardiomyopathy and heart block PMID: 14570980
    10. Not involved in the diabetes of NOD mice, as demonstrated in knockout mice. PMID: 14614561
    11. The microenvironment of I-Ab molecules that acquired their antigenic cargo in endosomes may be important for polarized tubulation of class II-positive compartments in antigen-presenting dendritic cells. PMID: 14634076
    12. Our results suggest that depletion of male sex steroids or blockade of androgen receptors using agents such as flutamide might prevent immunosuppression via maintaining MHC class II (Ia) expression after trauma and severe blood loss. PMID: 16614359
    13. Phogrin and IA-2 function as essential regulators of autocrine insulin action in pancreatic beta-cells. PMID: 19073770
    14. deletion of IA-2 and IA-2beta, structural proteins of secretory vesicles and modulators of neuroendocrine secretion, has a profound effect on the circadian system PMID: 19433624

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    MHC class II family
  • 數據庫鏈接：


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