在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse H (+)/Cl (-) exchange transporter 5 (Clcn5), partial

Recombinant Mouse H (+)/Cl (-) exchange transporter 5 (Clcn5), partial

  • 中文名稱：
    Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
  • 貨號：
    CSB-YP893433MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
  • 貨號：
    CSB-EP893433MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
  • 貨號：
    CSB-EP893433MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
  • 貨號：
    CSB-BP893433MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse H(+)/Cl(-) exchange transporter 5(Clcn5),partial
  • 貨號：
    CSB-MP893433MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Clcn5
  • Uniprot No.：
  • 別名：
    Clcn5; Clc5H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; ClC-5; Chloride transporter ClC-5
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
  • 基因功能參考文獻：
    1. This study demonistrated that Clcn5 gene expression in mouse dorsal raphe nucleus PMID: 22534482
    2. ClC-5 plays an essential role in exocytosis of NHE3. PMID: 21561868
    3. HNF1alpha directly regulates the expression of ClC-5 in the renal proximal tubule PMID: 20810608
    4. ClC-5 is unique among CLC proteins in being crucial for proximal tubular endocytosis and the PY-motif-dependent ubiquitylation of ClC-5 is dispensable for this rol PMID: 20351103
    5. findings show that endosomal chloride concentration, which is raised by ClC-5 in exchange for protons accumulated by H+-ATPase, may play a role in endocytosis PMID: 20430975
    6. Our studies demonstrate a role for CLC-5 in the immunopathogenesis of ulcerative colitis PMID: 20181886
    7. ClC-5 regulates dentin development through TGF-beta1 pathway PMID: 19878925
    8. Disruption of CLC-5 expression causes abnormal calcium crystal agglomeration on the surface of kidney collecting duct cells. PMID: 12504084
    9. hypercalciuria in the ClC-5 KO mice on low and high calcium diets is of bone and renal origin and is not caused by increased intestinal calcium absorption PMID: 12674322
    10. Impaired protein endocytosis caused by invalidation of ClC-5 primarily reflects a trafficking defect of megalin and cubilin in PTC. PMID: 12815097
    11. A role for CBS domain 2 in transport of CLC-5. PMID: 14521953
    12. The segmental expression of ClC-5 and H+-ATPase is essentially achieved during early nephrogenesis, in parallel with the onset of glomerular filtration. PMID: 14675051
    13. collecting duct cells with reduced CLC-5 expression lead to a tendency to form calcium crystal agglomeration PMID: 15158917
    14. increased CLC-5 levels in mouse medullary thick ascending limb may serve to maintain the endocytotic activity in a hypertonic environment. PMID: 15161605
    15. Our results provide direct evidence for ClC-5 involvement in acidification of early endosomes in proximal tubule by a chloride shunt mechanism. PMID: 15752747
    16. High citrate diet preserved renal function and delayed progression of renal disease in ClC-5 knockout mice even in the apparent absence of stone formation. PMID: 16014041
    17. ClC-5 has a role in apical iodide efflux and in euthyroid goiter in the mouse thyroid gland PMID: 16306076
    18. Target genes of 1,25(OH)(2)-vitamin D(3) were upregulated in ClC-5 knockout kidneys. PMID: 16672909
    19. in the thyroid, unlike in the kidney, ClC-5 does not affect megalin expression and function PMID: 16910872
    20. observed a significant decrease in solute carrier family 2 protein expression levels in isolated proximal tubule ((n=10, p<0.01)) of knockout mice PMID: 17762172

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, ClC-5/CLCN5 subfamily
  • 組織特異性：
    Kidney specific.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲国产一区二区三区| 亚洲一二区制服无码中字| 精品国产日韩亚洲一区| 一区一区三区产品乱码| 92国产精品午夜福利| 久久久亚洲精华液精华液精华液 | 97超碰精品成人国产| 精品服丝袜无码视频一区 | 8x福利精品第一导航| 国产suv精二区| 色偷偷女人的天堂亚洲网| 性欧美大战久久久久久久久| 久久99国产精品久久99果冻传媒 | 欧美色欧美亚洲另类二区| 亚洲a∨精品永久无码| 免费无码av片流白浆在线观看| 国产精品午夜无码av天美传媒| 精品国产精品久久一区免费式| 国产成人欧美亚洲日韩电影| 亚洲一卡2卡三卡4卡国色天香| 大胸少妇午夜三级| 欧美 日韩 人妻 高清 中文| 人妻少妇精品视频无码综合 | 成人国产网站v片免费观看| 又爽又黄无遮挡高潮视频网站| 国产成人青青久久大片| 亚洲精品少妇30p| 97影院理论片手机在线观看 | 精品欧美аv高清免费视频| 少妇愉情理伦片丰满丰满| 东京热无码av一区二区| 日韩丰满少妇无吗视频激情内射| 亚洲香蕉aⅴ视频在线播放 | 丁香五月婷激情综合第九色| 又粗又黄又猛又爽大片免费| 毛片免费视频| 成人精品视频一区二区三区尤物| 少妇spa推油被扣高潮| 中文字幕人妻丝袜乱一区三区 | 无码人妻丰满熟妇区五十路| 无码熟妇人妻av在线影片免费|