在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse General transcription factor II-I (Gtf2i), partial

In Stock
  • 中文名稱:
    Recombinant Mouse General transcription factor II-I (Gtf2i), partial
  • 貨號:
    CSB-EP875371MO
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    GTFII-I;TFII-I;Bruton tyrosine kinase-associated protein 135;BAP-135;BTK-associated protein 135
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    17.3 kDa
  • 表達區(qū)域:
    730-820aa
  • 氨基酸序列
    ITDLKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNKAKIKFIIKKPEMFETAIKESTS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
  • 基因功能參考文獻:
    1. The Cre-mediated deletion of exon 3 recapitulates a genetic null phenotype, indicating that the conditional Gtf2i line is a valuable tool for studying TFII-I function during embryonic development PMID: 27194223
    2. found a highly conserved DNA element, common to a set of genes regulated by TFII-I, and identified and validated novel in vivo neuronal targets of this protein affecting the PI3K and TGFbeta signaling pathways PMID: 23831514
    3. GTF2IRD2 has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones. PMID: 22899722
    4. data support the hypothesis that upregulation of TFII-I factors leads to activation of a specific group of developmental genes during mESC differentiation PMID: 22274952
    5. GTF2I duplication results in separation anxiety in mice and humans PMID: 22578324
    6. In order to clarify the involvement of GTF2I in neurocognitive function, especially social behavior, we have developed and characterized Gtf2i-deficient mice. PMID: 21328569
    7. Results suggest that DJ-1 together with TFII-I operate in concert to cope with various insults and to sustain pancreatic beta-cell function. PMID: 20516060
    8. behavioral characterization of heterozygous mice with a deletion of the first 140 amino-acids of TFII-I. PMID: 20403157
    9. data demonstrate that TFII-I, through a Src-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes PMID: 11934902
    10. acts as a transcriptional cofactor for the SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 PMID: 12193603
    11. TFII-I has a role in regulating immunoglobulin promoter activity PMID: 14645227
    12. TFII-I, involved in histone modification and SUMOylation, is expressed at early stages of embryogenesis. PMID: 14678824
    13. a unique growth factor signaling pathway is controlled by opposing activities of two TFII-I spliced isoforms PMID: 17052463
    14. The three-dimensional structure of the GTF2I domain is classified as a new fold, consisting of four helices, two antiparallel beta strands, and a well-defined loop containing two beta-turns between sheet 1 and helix 3. PMID: 17600150
    15. Gtf2i showed widespread expression in the developing head but was higher in the developing teeth than surrounding tissues throughout tooth development PMID: 17823943
    16. Bioinformatics and microarray results were combined to identify TFII-I downstream targets in the vertebrate genome. PMID: 18579769
    17. homozygous loss of Gtf2ird1 or Gtf2i results in multiple phenotypic manifestations, including embryonic lethality; brain hemorrhage; and vasculogenic, craniofacial, and neural tube defects; defects in yolk sac vasculogenesis and angiogenesis PMID: 19109438

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    TFII-I family
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产奶头好大揉着好爽视频| 久久久噜噜噜久久熟女色| 肥白大屁股bbwbbwhd| 国产内射爽爽大片| 久久久午夜精品福利内容| 亚洲国产成人av人片久久| 国产精品亚洲综合色区| 露脸叫床粗话东北少妇| 艳妇乳肉豪妇荡乳xxx| 国产玉足脚交极品在线播放| 污污网站18禁在线永久免费观看| 国产美女裸体无遮挡免费视频| 午夜射精日本三级| 亚洲精品无码成人网站| 波多野结衣av高清一区二区三区| 无套中出丰满人妻无码| 国产后入清纯学生妹| 久久中文字幕无码中文字幕有码| 亚洲欧美韩国综合色| 亚洲欧洲日产国产 最新| av片在线播放| 麻豆一区二区三区精品视频| 国产97公开成人免费视频在线观看| 国产美女遭强高潮网站观看| 精品无码久久久久久久久久| 欧美丰满一区二区免费视频 | 亚洲日韩成人av无码网站 | 45分钟免费真人视频| 精品国产三级a在线观看| av永久天堂一区| 亚洲精品一区二区三区四区乱码| 欧美日韩精品一区二区视频| 天堂√最新版中文在线天堂| 粗大的内捧猛烈进出视频| 国产精品毛片va一区二区三区| 国产情侣草莓视频在线| 亚洲色精品88色婷婷七月丁香| 亚洲国产精品成人久久| 久久www免费人成_看片| 欧美精品v欧洲精品| 无码av一区二区三区无码|