在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Gamma-interferon-inducible lysosomal thiol reductase (Ifi30)

Recombinant Mouse Gamma-interferon-inducible lysosomal thiol reductase (Ifi30)

  • 中文名稱：
    小鼠Ifi30重組蛋白
  • 貨號：
    CSB-YP872152MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ifi30重組蛋白
  • 貨號：
    CSB-EP872152MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ifi30重組蛋白
  • 貨號：
    CSB-BP872152MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ifi30; Gilt; Ip30; Gamma-interferon-inducible lysosomal thiol reductase; EC 1.8.-.-; Gamma-interferon-inducible protein IP-30; Lysosomal thiol reductase IP30
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    55-230
  • 氨基酸序列
    PSPPVR VSLYYESLCG ACRYFLVRDL FPTWLMVMEI MNITLVPYGN AQERNVSGTW EFTCQHGELE CRLNMVEACL LDKLEKEAAF LTIVCMEEMD DMEKKLGPCL QVYAPEVSPE SIMECATGKR GTQLMHENAQ LTDALHPPHE YVPWVLVNEK PLKDPSELLS IVCQLYQGTE
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.
  • 基因功能參考文獻(xiàn)：
    1. GILT has a role in maintaining cysteine cathepsin proteolytic efficiency in phagosomes PMID: 25253686
    2. These results show that wild-type mouse fibroblasts are relatively resistant and GILT(-/-)mouse fibroblasts are susceptible to Dengue virus 2 entry and replication. PMID: 23642353
    3. Data indicate that in the absence of Gamma-interferon-inducible lysosomal thiol reductase (GIL, CD4-positive T cell responses to major house dust mite allergen Der p 1 are significantly reduced. PMID: 23326313
    4. GILT has a critical role in regulating CD4(+) T-cell tolerance to an endogenous skin-restricted antigen relevant to controlling autoimmunity and generating effective immunotherapy for melanoma. PMID: 21833020
    5. gene knock-outs increase oxidative stress and autophagy, which is regulated by altering glutathione synthesis and oxidation PMID: 21640818
    6. GILT has limited yet unexpected effect on self-peptide species presented by major histocompatibility complex class II antigens. PMID: 20485683
    7. study shows GILT facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T cells or cross-presentation;initiation of gB-specific CD8+ T cell response during HSV-1 infection or cross-priming is GILT-dependent PMID: 20538950
    8. the thiol reductase activity of GILT is its essential function in MHC class II-restricted Ag processing PMID: 17142755
    9. findings show that endogenously produced peptide-IgG is processed by transduced splenic B cells in the lysosomes/endosomes in a GILT-dependent manner, and this endocytic processing pathway is essential for generating tolerogenic B cells PMID: 18606668
    10. Replication of Listeria monocytogenes in GILT-negative macrophages, or macrophages expressing an enzymatically inactive GILT mutant, is impaired because of delayed escape from the phagosome PMID: 18815593
    11. Expression of GILT in T-lymphocytes increases as a function of maturity, thereby reducing sensitivity of T-cells and consequences of autoimmune responses; a role of GILT in the immune system may be in reducing the impact of T-cell autoreactivity. PMID: 19124716
    12. GILT facilitated the processing and presentation to antigen-specific T cells of protein antigens containing disulfide bonds. PMID: 11701933

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted. Lysosome.
  • 蛋白家族：
    GILT family
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 精品无码久久久久国产手机版| 国产成人精品日本亚洲专区61| 丁香五月欧美成人| 日本japanese丰满白浆 | 狠狠综合久久av一区二区| 色欲av无码一区二区人妻| 天堂最新版资源网| 亚洲精品无码中文久久字幕| 亚洲裸男自慰gv网站| 性欧美暴力猛交69hd| 成人毛片无码免费播放网站| 国产粉嫩小泬在线观看泬| 沈阳熟女露脸对白视频 | 欧美影院成年免费版| 欧美精品乱码99久久蜜桃| 国产精品黄页免费高清在线观看| 亚洲aⅴ天堂av天堂无码app| 97色精品视频在线观看| 日本少妇毛茸茸高潮| 中文无码熟妇人妻av在线| 亚洲欧洲成人a∨在线观看| 伊人久久大香线蕉av五月天| 亚洲中文字幕无码一区| 手机看片福利一区二区三区| 久久 国产 尿 小便 嘘嘘| 国产午夜精品一二区理论影院| 亚洲熟妇无码av不卡在线播放| 国产乱xxxxx97国语对白| 囯产精品久久久久久久久久妞妞| 在线观看国产午夜福利片| 久久99精品国产99久久6不卡 | 少妇人妻系列无码专区视频| 国产高清在线精品一本大道| 色老头精品午夜福利视频| 天堂а在线中文在线新版| 亚洲精品日韩一区二区电影| 国产无限次数成版人视频在线 | 啪啪后入内射日韩| 国产精品二区一区二区aⅴ污介绍| 美女视频黄是免费| 色猫咪av在线观看|