在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse G protein-coupled receptor kinase 6 (Grk6)

Recombinant Mouse G protein-coupled receptor kinase 6 (Grk6)

  • 中文名稱：
    小鼠Grk6重組蛋白
  • 貨號：
    CSB-YP009927MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Grk6重組蛋白
  • 貨號：
    CSB-EP009927MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Grk6重組蛋白
  • 貨號：
    CSB-EP009927MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Grk6重組蛋白
  • 貨號：
    CSB-BP009927MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Grk6重組蛋白
  • 貨號：
    CSB-MP009927MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Grk6; Gprk6; G protein-coupled receptor kinase 6; EC 2.7.11.16; G protein-coupled receptor kinase GRK6
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-576
  • 氨基酸序列
    MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ PIGRLLFREF CATRPELTRC TAFLDGVSEY EVTPDEKRKA CGRRLMQNFL SHTGPDLIPE VPRQLVSNCA QRLEQGPCKD LFQELTRLTH EYLSTAPFAD YLDSIYFNRF LQWKWLERQP VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVRNE RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVAEEYTD RFSSQARSLC SQLLSKDPAE RLGCRGGGAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI EQFSTVKGVD LEPTDQDFYQ KFATGSVSIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK GQPTAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
  • 基因功能參考文獻(xiàn)：
    1. Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo. PMID: 28457871
    2. These studies suggest a previously unrecognized and novel role for GRK6 in neutrophil migration specific to pulmonary tissue during bacterial infection. PMID: 28939643
    3. Silencing of GRK6 expression by siRNA impairs CXCR4-serine 339 phosphorylation and migration of cardiac stem cellss caused by SCF. In vivo, knockdown of GRK6 impairs the ability of CSCs to migrate into peri-infarcted areas. PMID: 27245949
    4. This work demonstrates the importance of GRK6 in regulation of hematopoietic stem cell self-renewal and reveals its potential role in participation of stress response. PMID: 27882944
    5. GRK6-mediated OXTR desensitization in labor is necessary for normal uterine contractile patterns and optimal fetal outcome. PMID: 26886170
    6. It regulates apoptotic engulfment in phagocytes. (review) PMID: 26234352
    7. these results indicate that GRK6 complexes with AGS3-Galphai2 to regulate CXCR2-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane. PMID: 24510965
    8. data demonstrate that GRK6 plays a feedback regulatory role in CXCR2-mediated tumor development, invasion and metastasis PMID: 23589623
    9. G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance. PMID: 23443560
    10. Chemokine receptor CXCR2 interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis. PMID: 22869904
    11. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling. PMID: 19801552
    12. deficiency causes defective lymphocyte chemotaxis PMID: 12032308
    13. Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity. PMID: 12718862
    14. In the absence of GRK6, the G-CSF-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF, significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice. PMID: 14704365
    15. The results suggest that mouse G-protein-coupled receptor kinase isoform 6-C may be considered a basic, prototypic representative of the GRK4-like kinases. PMID: 16302968
    16. GRK6 and -2, but not GRK5, are involved in the pathogenesis of acute arthritis in the K/BxN model. In particular, GRK6 may dampen inflammatory responses by regulating granulocyte trafficking toward chemoattractants. PMID: 18662895
    17. Data show an important protective role for GRK6 against post-inflammatory visceral hyperalgesia. PMID: 18977289
    18. these results suggest that GRK6 may play a role in regulating some, but not all morphine-mediated responses. PMID: 19497686

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Membrane; Lipid-anchor.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  • 組織特異性：
    Expressed in the brain in striatal neurons.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 国内精品美女视频免费直播| 欧美刺激性大交| 毛色毛片免费观看| 欧美乱强伦xxxxx高潮| 国产成人av性色在线影院色戒| 国产又粗又猛又爽又黄的视频在线观看动漫 | 特级毛片爽www免费版| 粉嫩粉嫩的18在线观看| 亚洲最大激情中文字幕| 亚洲人成欧美中文字幕| 国产成人三级一区二区在线观看一 | 激情五月综合色婷婷一区二区| 正在播放重口老熟女露脸| 婷婷四虎东京热无码群交双飞视频| 久久精品第九区免费观看| 无码福利日韩神码福利片| 国产精成人品| ww欧日韩视频高清在线| 中文无码日韩欧| 中文字幕亚洲日韩无线码| 青青草国产精品免费观看| 精品露脸国产偷人在视频| 亚洲日韩乱码中文无码蜜桃臀| 夜夜爽一区二区三区精品| 久久久久久人妻毛片a片 | 国产精品自在线拍国产电影| 久久综合伊人九色综合| 国产精品免费视频色拍拍| 屁屁影院ccyy备用地址| 亚洲国产美女精品久久久久∴| 国产日产欧产精品精品app| 欧美肥老太交性506070| 老熟女高潮一区二区三区| 国产一区二区三区免费高清在线播放| 亚洲日韩国产中文其他| 夜夜高潮夜夜爽夜夜爱| 精品人妻中文字幕有码在线| 午夜无码一区二区三区在线| 秋霞av鲁丝片一区二区| 亚洲精品久久久蜜桃| 亚洲综合电影小说图片区|