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  4. Recombinant Mouse G-protein coupled receptor 126 (Gpr126), partial

Recombinant Mouse G-protein coupled receptor 126 (Gpr126), partial

  • 中文名稱：
    Recombinant Mouse G-protein coupled receptor 126(Gpr126) ,partial
  • 貨號(hào)：
    CSB-YP739635MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse G-protein coupled receptor 126(Gpr126) ,partial
  • 貨號(hào)：
    CSB-EP739635MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse G-protein coupled receptor 126(Gpr126) ,partial
  • 貨號(hào)：
    CSB-EP739635MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse G-protein coupled receptor 126(Gpr126) ,partial
  • 貨號(hào)：
    CSB-BP739635MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse G-protein coupled receptor 126(Gpr126) ,partial
  • 貨號(hào)：
    CSB-MP739635MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Adgrg6; Dreg; Gm222; Gpr126Adhesion G-protein coupled receptor G6; Developmentally regulated G-protein-coupled receptor; G-protein coupled receptor 126) [Cleaved into: ADGRG6 N-terminal fragment; ADGRG6-NTF); ADGRG6 C-terminal fragment; ADGRG6-CTF)]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons these functions are mediated via G-protein-signaling pathways. Regulates also neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis.; Plays an important role in heart developmention. Necessary and sufficient for axon sorting by Schwann cells independently of the ADGRG6-CTF.
  • 基因功能參考文獻(xiàn)：
    1. we show that the adhesion class G protein-coupled receptor (GPCR) Gpr126/Adgrg6 is required for remyelination, macrophage recruitment, and axon regeneration following nerve PMID: 27927955
    2. PrP(C) promotes myelin homeostasis through flexible tail-mediated Gpr126 agonism PMID: 27501152
    3. Together, these data uncover Gpr126 as a genetic cause for the pathogenesis of Adolescent idiopathic scoliosis (AIS) and pectus excavatum in a mouse model. PMID: 25954032
    4. GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling PMID: 25217645
    5. a model in which the NTF of Gpr126, in contrast to the C-terminal fragment, plays an important role in heart development. PMID: 24082093
    6. Analysis shows that Gpr126 is required for Schwann cell myelination in mammals, and defines new roles for Gpr126 in axonal sorting, formation of mature non-myelinating Schwann cells and organization of the perineurium. PMID: 21613327
    7. Data show that GPR126 is required for embryonic viability and cardiovascular development. PMID: 21124978

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 組織特異性：
    Expressed at high levels in the heart, somite and otic vesicle during embryogenesis and in adult lung.
  • 數(shù)據(jù)庫鏈接：


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