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  4. Recombinant Mouse Formin-2 (Fmn2), partial

Recombinant Mouse Formin-2 (Fmn2), partial

  • 中文名稱：
    小鼠Fmn2重組蛋白
  • 貨號：
    CSB-YP864361MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Fmn2重組蛋白
  • 貨號：
    CSB-EP864361MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Fmn2重組蛋白
  • 貨號：
    CSB-EP864361MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Fmn2重組蛋白
  • 貨號：
    CSB-BP864361MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Fmn2重組蛋白
  • 貨號：
    CSB-MP864361MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Fmn2Formin-2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Protects cells against apoptosis by protecting CDKN1A against degradation.
  • 基因功能參考文獻：
    1. FlnA and Fmn2 are likely essential to cell proliferation, differentiation and cell death in a variety of tissues and organs, further reiterating the importance of vesicle trafficking in regulation of development PMID: 29240780
    2. Fmn2 mutant mice develop accelerated age-associated memory decline that is further increased in the presence of additional risk factors and is mechanistically linked to a loss of transcriptional homeostasis. PMID: 28768717
    3. Fmn2 as a mediator of actin bundle integrity, enabling efficient force transmission to the adhesion sites. PMID: 26718007
    4. Data suggest formin homology domain (FH2) of Fmn2 binds actin at filament barbed end as weak capper and plays a role in displacing WASP homology domain 2 (WH2) domains of Spire-1 from actin; competitive binding of Fmn2 vs Spire-1 aids actin assembly. PMID: 26668326
    5. Spire recruits Fmn2 and facilitates its association with actin filaments barbed ends. PMID: 24586110
    6. Results suggest that the regulation of microtubule acetylation is likely a general formin activity. PMID: 23110170
    7. analysis of the molecular basis of the Spir1/formin-2 interaction PMID: 21705804
    8. Spire1 and Spire2 cooperate with Formin-2 (Fmn2) to nucleate actin filaments in mouse oocytes. PMID: 21620703
    9. High formin 2 levels at meiosis I entry induce meshwork maintenance, leading to equal forces being exerted on the chromosomes, preventing spindle migration. PMID: 21653611
    10. Gene profiling of Fmn2 in Graffi murine leukemia virus-induced lymphoid leukemias suggest its important role in leukemogenesis. PMID: 21135260
    11. Fmn2 is a candidate in a QTL hotspot associated with neurobehavioral traits and gene expression in the mouse brain. Hippocampal pyramidal neurons exhibit distinct and fine granular immunoreactivity for FMN2. PMID: 19008955
    12. formin-2 is a maternal-effect gene that is expressed in oocytes and is required for progression through metaphase of meiosis I PMID: 12447394
    13. The mouse formin-2 gene has been found to be expressed in the developing nervous system and in neuronal cells of the adult brain. PMID: 15053972
    14. It is likely that human FMN2 has the same function as Fmn2 in the mouse (i.e., maintenance of the meiotic spindle). PMID: 15866570

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Nucleus. Nucleus, nucleolus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Formin homology family, Cappuccino subfamily
  • 組織特異性：
    Detected in brain and in oocytes (at protein level). Expressed almost exclusively in the developing and mature central nervous system. Detected in oocytes.
  • 數據庫鏈接：


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