在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Ficolin-1 (Fcn1)

In Stock
  • 中文名稱:
    小鼠Fcn1重組蛋白
  • 貨號(hào):
    CSB-EP008550MOa0
  • 規(guī)格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度:
    Full Length of Mature Protein
  • 來(lái)源:
    E.coli
  • 分子量:
    38.5 kDa
  • 表達(dá)區(qū)域:
    18-334aa
  • 氨基酸序列
    SQALGQERGACPDVKVVGLGAQDKVVVIQSCPGFPGPPGPKGEPGSPAGRGERGFQGSPGKMGPAGSKGEPGTMGPPGVKGEKGDTGAAPSLGEKELGDTLCQRGPRSCKDLLTRGIFLTGWYTIHLPDCRPLTVLCDMDVDGGGWTVFQRRVDGSIDFFRDWDSYKRGFGNLGTEFWLGNDYLHLLTANGNQELRVDLQDFQGKGSYAKYSSFQVSEEQEKYKLTLGQFLEGTAGDSLTKHNNMSFTTHDQDNDANSMNCAALFHGAWWYHNCHQSNLNGRYLSGSHESYADGINWGTGQGHHYSYKVAEMKIRAS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
  • 基因功能參考文獻(xiàn):
    1. Ficolin-2 induces macrophage activation, promotes M1 polarization and facilitates proliferation and antigen-specific cytotoxicity of CD8(+) T cells. Ficolin-2 binds to Toll-like receptor 4 (TLR4) on macrophages and DCs and promotes their antigen-presenting abilities to CD8(+) T cells. PMID: 28844702
    2. this study demonstrates that ficolins are important in initial innate host defense against Aspergillus fumigatus infections in vivo PMID: 27467404
    3. this study shows that FCN-A/2 exacerbated the inflammatory pathogenesis of inflammatory bowel disease by stimulating M1 polarization through the TLR4/MyD88/MAPK/NF-kappaB signalling pathway in macrophages PMID: 28380665
    4. FcnA-deficient and FcnA/ficolin B double-deficient mice lack FcnA-mediated complement activation in the sera, because of absence of complexes comprising FcnA and MBL-associated serine proteases. PMID: 23150716
    5. the binding properties of the murine serum ficolin-A towards a panel of different clinical relevant microorganisms PMID: 22666482
    6. binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo PMID: 22399010
    7. Recombinant mouse ficolin A, mannose-binding lectin-A, and mannose-binding lectin-C bound to fibrinogen in a dose-dependent manner. The lectin pathway, through mannose-binding lectins, synchronized with blood coagulation. PMID: 20375621
    8. the expression pattern of ficolin A expression was closely similar to that of mannose-binding lectin-associated serine proteases, suggesting that these molecules may function in coordination as components of the lectin complement pathway PMID: 15950722
    9. Ficolin A protein (smapshowed a potent complement activating capacity.These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway. PMID: 16328467
    10. A functionally relevant signal peptide of ficolin A was identified by using mass spectrometry analysis to determine the N-terminal sequence of secreted ficolin A. PMID: 17669269

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted. Cell membrane; Peripheral membrane protein; Extracellular side.
  • 蛋白家族:
    Ficolin lectin family
  • 組織特異性:
    Highly expressed in liver and spleen.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 阳茎伸入女人阳道视频| 久久俺也去丁香综合色| 亚洲a∨精品无码一区二区| 亚洲一区二区三区国产精品无码| 日本japanese漂亮丰满| 玩超薄丝袜人妻的经历| 波多野结衣av手机在线观看 | 中文字幕色av一区二区三区| 亚洲熟妇色xxxxx欧美老妇| 四虎影视88aa久久人妻| 3d成人h动漫网站入口| 久久久久蜜桃精品成人片公司| 人妻熟女一区| 日韩一本之道一区中文字幕| 风韵人妻丰满熟妇老熟女| 日本少妇无码精品12p| 久青草国产在视频在线观看| 亚洲成av人片在线观看无码| 国产av仑乱内谢| 欧美变态另类xxxx| 国产精品天干天干在线综合| 99久久精品视香蕉蕉| 久久综合伊人77777麻豆| 亚洲精品一区中文字幕乱码| 精品久久欧美熟妇www| 亚洲国产老鸭窝一区二区三区| 亚洲精品在看在线观看高清| 丰满人妻熟妇乱又伦精品| 硬了进去湿好大娇喘视频| 久久国产免费观看精品a片| 任你躁在线精品免费| 欧美高清在线精品一区| 麻豆国产精品va在线观看| 国产在线无码视频一区二区三区| 亚洲性无码av在线dvd| 人妻无码久久久久久久久久久| 欧美大黑帍在线播放| 国产成人精品午夜视频| 男男又爽又黄又无遮挡网站| 色拍拍欧美视频在线看| 精品无码久久久久国产手机版|