在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse F-box only protein 2 (Fbxo2)

Recombinant Mouse F-box only protein 2 (Fbxo2)

  • 中文名稱：
    小鼠Fbxo2重組蛋白
  • 貨號(hào)：
    CSB-YP802228MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Fbxo2重組蛋白
  • 貨號(hào)：
    CSB-EP802228MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Fbxo2重組蛋白
  • 貨號(hào)：
    CSB-EP802228MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Fbxo2重組蛋白
  • 貨號(hào)：
    CSB-BP802228MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Fbxo2重組蛋白
  • 貨號(hào)：
    CSB-MP802228MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Fbxo2; Fbs1; Fbx2F-box only protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-297
  • 氨基酸序列
    MDGDGDPESV SHPEEASPEE QPEEAGAEAS AEEEQLREAE EEEEAEAVEY LAELPEPLLL RVLAELPATE LVQACRLVCL RWKELVDGAP LWLLKCQQEG LVPEGSADEE RDHWQQFYFL SKRRRNLLRN PCGEEDLEGW SDVEHGGDGW RVEELPGDNG VEFTQDDSVK KYFASSFEWC RKAQVIDLQA EGYWEELLDT TQPAIVVKDW YSGRTDAGSL YELTVRLLSE NEDVLAEFAT GQVAVPEDGS WMEISHTFID YGPGVRFVRF EHGGQDSVYW KGWFGARVTN SSVWVEP
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
  • 基因功能參考文獻(xiàn)：
    1. F-box only protein 2 (FBXO2), a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex, was upregulated in livers of obese mice. Furthermore, using a protein purification approach combined with high-performance liquid chromatography/tandem mass spectrometry, we carried out a system-wide screening of FBXO2 substrates, in which the insulin receptor (IR) was identified as a substrate PMID: 27932386
    2. FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy. PMID: 26295339
    3. The results of this study suggested that Fbxo2 controls the abundance and localization of specific NMDAR subunits in the brain and may influence synapse formation and maintenance. PMID: 25878288
    4. these results suggest that Fbxo2 regulates APP levels and processing in the brain and may play a role in modulating Alzheimer disease pathogenesis. PMID: 24469452
    5. our studies support a non-essential role for FBG1 on the degradation of torsinA and uncover a novel link of FBG1 to the autophagy pathway. PMID: 22917612
    6. When expressed in hippocampal neurons, the Fbx2 dominant-negative mutant augmented NR1 subunit levels and NMDA receptor-mediated currents in an activity-dependent fashion PMID: 15809437
    7. Fbs1 assists clearance of aberrant glycoproteins in neuronal cells by suppressing aggregates formation, independent of ubiquitin ligase activity, and thus functions as a unique chaperone for those proteins. PMID: 17215248
    8. Our findings demonstrate that components of protein quality control are essential for inner ear homeostasis and implicate Fbx2 and Skp1 as potential genetic modifiers in age-related hearing loss. PMID: 17494702

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 組織特異性：
    Detected in brain and cochlea, in epithelial support cells and hair cells of the organ of Corti (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 亚洲欧美日韩在线一区| 亚洲欧美人高清精品a∨| 香蕉在线依人视频| 国产真实老熟女无套内射| 久久九九久精品国产免费直播| 四虎精品成人免费视频| 久国产精品人妻aⅴ| 蜜臀av国产精品久久久久| 把插八插露脸对白内射| 亚洲午夜av久久久精品影院| 亚洲大乳高潮日本专区| 亚洲人成网站在线无码| 国产午夜av秒播在线观看| 欧美丰满熟妇xxxx性| 无码一区二区三区中文字幕 | 国产熟妇乱子伦视频在线观看| 久久人妻天天av| 麻豆久久久9性大片| 国产午夜亚洲精品一区| 国产97色在线 | 欧洲| 免费看成人aa片无码视频羞羞网| 高潮内射免费看片| 久久亚洲日韩av一区二区三区| 欧美大片aaaaa免费观看| 精品国精品无码自拍自在线| 欧牲交a欧美牲交aⅴ| 2020精品国产视| 国产精品女视频一区二区| 欧美高清在线精品一区| 久久精品国产亚洲夜色av网站 | 国产丶欧美丶日本不卡视频| 一二三区乱码不卡手机版| 亚洲乱码卡一卡二卡新区仙踪木木| av无码久久久久不卡网站蜜桃| 宅宅少妇无码| 99久久久无码国产精品动漫| 亚洲伦无码中文字幕另类| 国产女人好紧好爽| 2020每日更新国产精品视频| 久久天天躁狠狠躁夜夜2o2o| 中文字幕无码免费久久|