Recombinant Mouse E3 ubiquitin-protein ligase RNF125 (Rnf125)

中文名稱：

小鼠Rnf125重組蛋白
貨號：

CSB-YP884037MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Rnf125重組蛋白
貨號：

CSB-EP884037MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Rnf125重組蛋白
貨號：

CSB-EP884037MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rnf125重組蛋白
貨號：

CSB-BP884037MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rnf125重組蛋白
貨號：

CSB-MP884037MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rnf125
Uniprot No.：

Q9D9R0
別名：

Rnf125; E3 ubiquitin-protein ligase RNF125; EC 2.3.2.27; RING finger protein 125
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

2-233
氨基酸序列

GSLLSSDSS KSAPASATPR TLERSGDSEL PITSFDCSVC LEVLHQPVRT RCGHVFCRSC IATSIKNNNK WTCPYCRAYL PSEGVPATDI AKRMKSEYQN CAECGTLVCL SDMRAHIRTC EKYIDKYGPL LELGDTTARC VCPFCQRELD EDCLLDHCII HHRSERRPVF CPLCHSRPDE SPSTFNGSLI RHLQVSHTLF YDDFIDFDII EEAIIRRVLD RSLLEYVNQS NTT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.
基因功能參考文獻：
1. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response PMID: 28476934
2. Data indicate that brain from Japanese encephalitis virus (JEV)-infection showed a reciprocal correlation between microRNA miR-15b levels and the expression of ring finger protein 125 (RNF125). PMID: 26202983
3. RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production PMID: 17460044
亞細胞定位：

Golgi apparatus membrane; Lipid-anchor.
數(shù)據(jù)庫鏈接：

KEGG: mmu:67664

STRING: 10090.ENSMUSP00000058251

UniGene: Mm.45980