在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse E3 ubiquitin-protein ligase FANCL (Fancl)

  • 中文名稱:
    小鼠Fancl重組蛋白
  • 貨號:
    CSB-YP871894MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Fancl重組蛋白
  • 貨號:
    CSB-EP871894MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Fancl重組蛋白
  • 貨號:
    CSB-EP871894MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Fancl重組蛋白
  • 貨號:
    CSB-BP871894MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Fancl重組蛋白
  • 貨號:
    CSB-MP871894MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Fancl; Phf9; PogE3 ubiquitin-protein ligase FANCL; EC 2.3.2.27; Fanconi anemia group L protein homolog; Proliferation of germ cells protein; RING-type E3 ubiquitin transferase FANCL
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-375
  • 氨基酸序列
    DEAEASLLR HFPLLLPQNR EKTVYEGFIS AQGSDFHLRI VLPKDLQLKK ARLLCSLQLK NILNEYHQVV QQRMKHSPDL MSFMMELKMI LEVALKNKQE LCVQPPSCSF CKDLLTEIGA IGWDKLACVE SSFSTIKLKA DDASGRKHLI TVKLKAKYPV EPPDCVVDFP VPFSVSWTPQ SSLVDVYSQF LVALETLKVF WDVMDEIDEK TWVLEPEKPP RSATARRIAL GKNVSIAIEV DPRHPTMLPE FCFLGADHVT KPLGMKLSGS IHLWDPENSL LQNLKDVLEI DFPARSILEE SDFSMDCGIC YARHLNGAIP DQVCNNPQCG QPFHEICLYE WLRGLSTSRQ SFNVFFGDCP YCSKPITLKM SGRKP
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
  • 基因功能參考文獻:
    1. The authors report the structure of the human FANCL central domain and show that the RING domain is necessary and sufficient for E2 binding. PMID: 21775430
    2. Using HeLa cells and lymphoblasts from Fanconi anemia patients, the authors characterize PHF9 (FANCL) as a ubiquitin ligase and show it is essential for FANCD2 monoubiquitination. The authors state that PHF9 is the human homolog of mouse Pog (Fancl). PMID: 1297335
    3. FANCL increases the activity and expression of beta-catenin, a key pluripotency factor in hematopoietic stem cells. PMID: 22653977
    4. Fancl is associated with acute lung injury PMID: 21297076
    5. expression of a novel splice variant of FA complementation group L (FANCL), named FAVL, can impair the FA pathway in non-FA tumor cells and act as a tumor promoting factor PMID: 20407210
    6. Deletion of Pog causes germ cell deficiency, but is also accompanied by reduced embryonic body weight and sometimes lethality. PMID: 12417526
    7. GGN1 and GGN3, interacted with POG, regulated the localization of POG, and played a role in spermatogenesis. PMID: 12574169
    8. unlike in POG-deficient females, the germ cells in POG-deficient males eventually populate the seminiferous tubules at 9 wk, and fertility can be achieved by 12 wk. PMID: 12606378
    9. Germ cell depletion 2 (gcd2) is a chemically induced recessive mutation that causes infertility in male and female mice. PMID: 16822657

    顯示更多

    收起更多

  • 相關疾病:
    Defects in Fancl are a cause of the gcd (germ cell deficient) mutant phenotype, which leads to reduced numbers of precursor germ cells and adult sterility, probably due to a reduced precursor germ cells proliferation.
  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=In the nucleus, colocalizes with UBE2W.
  • 數據庫鏈接:


主站蜘蛛池模板: 99e热久久免费精品首页| 无码国产一区二区免费| 18禁无遮挡啪啪无码网站| 亚洲人成在线影院| 午夜射精日本三级| 欧洲美熟女乱又伦av影片| 国产在线精品无码不卡手机免费 | 8av国产精品爽爽ⅴa在线观看 | 久久精品成人免费观看97| 精品综合久久久久久97| 久久狠狠色噜噜狠狠狠狠97| 国产jk精品白丝av在线观看| 日韩成人一区二区三区在线观看| 狠狠人妻久久久久久综合 | 无码视频一区二区三区| 欧美日韩午夜群交多人轮换| 无码人妻一区二区三区精品视频| 国产精品进线69影院| 精品国产乱码久久久久久下载| 国产放荡对白视频在线观看| 亚洲男人最新版本天堂| 国产女人18毛片水真多1| 久久综合色鬼综合色| 日韩av无码社区一区二区三区| 亚洲最大无码av网站观看| 最新 国产 精品 精品 视频| 夜夜躁很很躁日日躁麻豆 | 日韩精品一区二区av在线| 欧美日韩亚洲国产在线制服| 野外做受三级视频| 亚洲一区二区三区香蕉| 日韩精品一区二区三区影院| 印度妓女野外xxww| 无码国产成人午夜在线观看| 丰满少妇69激情啪啪无| 西西人体44www大胆无码| 色欲久久综合亚洲精品蜜桃 | 欧美成人精品第一区二区三区| 欧美日韩不卡视频合集| 国产在线第一区二区三区| 国产又色又爽又黄的免费|