在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Double C2-like domain-containing protein beta (Doc2b)

Recombinant Mouse Double C2-like domain-containing protein beta (Doc2b)

  • 中文名稱：
    小鼠Doc2b重組蛋白
  • 貨號：
    CSB-YP007092MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Doc2b重組蛋白
  • 貨號：
    CSB-EP007092MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Doc2b重組蛋白
  • 貨號：
    CSB-EP007092MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Doc2b重組蛋白
  • 貨號：
    CSB-BP007092MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Doc2b重組蛋白
  • 貨號：
    CSB-MP007092MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Doc2b
  • Uniprot No.：
  • 別名：
    Doc2bDouble C2-like domain-containing protein beta; Doc2-beta
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-412
  • 氨基酸序列
    MTLRRRGEKA TISIQEHMAI DVCPGPIRPI KQISDYFPRF PRGLPPTAAP RAPAPPDAPA RSPAASASPR SPSDGARDDD EDVDQLFGAY GASPGPSPGP SPARPPAKPP EDEPDVDGYE SDDCTALGTL DFSLLYDQEN NALHCTISKA KGLKPMDHNG LADPYVKLHL LPGASKANKL RTKTLRNTLN PSWNETLTYY GITDEDMVRK TLRISVCDED KFRHNEFIGE TRVPLKKLKP NHTKTFSICL EKQLPVDKAE DKSLEERGRI LISLKYSSQK QGLLVGIVRC AHLAAMDANG YSDPYVKTYL KPDVDKKSKH KTAVKKKTLN PEFNEEFCYE IKHGDLAKKT LEVTVWDYDI GKSNDFIGGV VLGINAKGER LKHWFDCLKN KDKRIERWHT LTNELPGAVL SD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
  • 基因功能參考文獻：
    1. Reduction of DOC2B is an early feature of T1 diabetes (T1D), and DOC2B abundance may serve as a valuable in vivo indicator of beta-cell mass and an early biomarker of T1D. PMID: 29506054
    2. Doc2b enrichment in the beta-cell protects against diabetogenic and proapoptotic stress. PMID: 29661782
    3. Mutating Ca(2+)-coordinating aspartates in the C2A-domain localizes Doc2B permanently at the plasma membrane, and renders an upstream priming step Ca(2+)-independent, whereas a separate function in downstream priming depends on SNARE-binding, Ca(2+)-binding to the C2B-domain of Doc2B, interaction with ubMunc13-2 and the presence of synaptotagmin-1. PMID: 29274147
    4. Data demonstrate that Munc13-1 and DOC2B have different effects on network activity and that by enhancing asynchronous release, DOC2B exerts its properties to increase spiking activity and elevate synchronization between neurons within network bursts PMID: 23537531
    5. Hence these data support a working model wherein Doc2b functions as a docking platform/scaffold for transient interactions with the multiple Munc18 isoforms operative in insulin release, promoting SNARE assembly. PMID: 25190515
    6. Doc2b is a limiting factor in SNARE exocytosis events pertinent to glycaemic regulation in vivo. Doc2b enrichment may provide a novel means to simultaneously boost islet and skeletal muscle function in vivo in the treatment and/or prevention of diabetes. PMID: 24705606
    7. Mutations that disrupt Ca(2)-binding activity endow Doc2beta with novel functional properties during synaptic transmission. PMID: 24356452
    8. Doc2b acts to inhibit vesicle priming during prolonged calcium elevations, thus protecting unprimed vesicles from fusing prematurely, and redirecting them to refill the readily releasable pool after relaxation of the calcium signal. PMID: 24133251
    9. Doc2b is a key positive regulator of Munc18c-syntaxin 4-mediated insulin secretion as well as of insulin responsiveness in skeletal muscle, and thus a key effector for glucose homeostasis in vivo. PMID: 22698913
    10. The data of this study suggested that Doc2s are modulators of spontaneous synaptic transmission that act by a Ca(2+)-independent mechanism. PMID: 21521611
    11. study found that Doc2b is a high-affinity Ca2+ sensor for half (hippocampus) or most (cerebellum) of the spontaneous neurotransmitter release events in CNS synapses PMID: 20150444
    12. tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2beta PMID: 18541526
    13. We conclude that DOC2B is a calcium-dependent priming factor and its activity at the PM enables efficient expansion of the fusion pore, leading to increased catecholamine release. PMID: 18596155
    14. Fndings indicate that DOC2b is a positive SNARE regulator for GLUT4 vesicle fusion and mediates insulin-stimulated glucose transport in adipocytes. PMID: 19033398
    15. These data suggest that DOC2b may be a regulator for delayed (second-phase) insulin secretion in MIN6 cells. PMID: 19410553

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane in a calcium-dependent manner.
  • 組織特異性：
    Widely expressed. Expressed in pancreatic islet cells (at protein level).
  • 數據庫鏈接：

    KEGG: mmu:13447

    STRING: 10090.ENSMUSP00000021209

    UniGene: Mm.5137



主站蜘蛛池模板： 亚洲国产精品18久久久久久| 欧美日本免费一区二区三区| 国产女人好紧好爽| 亚洲爆乳www无码专区| 久久亚洲道色综合久久| 高中生粉嫩无套第一次| 人妻少妇精品无码专区app| 性生交大全免费看| 亚洲狠狠色成人综合网| 国产福利酱国产一区二区| 国产无人区码一码二码三mba| 特级无码毛片免费视频| 桃花综合久久久久久久久久网| 国产精品福利2020久久| 无码办公室丝袜ol中文字幕 | 亚洲经典千人经典日产| 永久免费无码成人网站| 2021在线不卡国产麻豆| 亚洲国产成人无码av在线| 国产精品久久久天天影视| 九九热爱视频精品| 国内精品伊人久久久久网站| 欧美性猛交xxxx免费看蜜桃| 一区二区三区波多野结衣在线观看| 99精品久久久久中文字幕| 欧美搡bbbbb搡bbbbb| 成人做受视频试看60秒| 无码av免费一区二区三区a片| 中文字幕精品亚洲人成在线| 野外少妇愉情中文字幕| 中文日韩亚洲欧美制服 | 亚洲中文字幕丝祙制服| 国产无遮挡又爽又黄的视频| 好吊色欧美一区二区三区四区| 日韩日韩日韩日韩日韩| 日韩成人无码v清免费| 国产av午夜精品一区二区三区| 精品一区精品二区制服| 久久中文字幕乱码久久午夜| 久久性色av亚洲电影| 十八岁以下禁止观看黄下载链接|