在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Dihydropyrimidinase-related protein 2 (Dpysl2)

Recombinant Mouse Dihydropyrimidinase-related protein 2 (Dpysl2)

  • 中文名稱：
    小鼠Dpysl2重組蛋白
  • 貨號：
    CSB-YP007170MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Dpysl2重組蛋白
  • 貨號：
    CSB-EP007170MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Dpysl2重組蛋白
  • 貨號：
    CSB-EP007170MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Dpysl2重組蛋白
  • 貨號：
    CSB-BP007170MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Dpysl2重組蛋白
  • 貨號：
    CSB-MP007170MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Dpysl2; Crmp2; Ulip2Dihydropyrimidinase-related protein 2; DRP-2; Unc-33-like phosphoprotein 2; ULIP-2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-572
  • 氨基酸序列
    MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI VPGGVKTIEA HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGTSLLAAF DQWREWADSK SCCDYSLHVD ITEWHKGIQE EMEALVKDHG VNSFLVYMAF KDRFQLTDSQ IYEVLSVIRD IGAIAQVHAE NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRSI TIANQTNCPL YVTKVMSKSA AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL IPEGTNGTEE RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR ISVGSDADLV IWDPDSVKTI SAKTHNSALE YNIFEGMECR GSPLVVISQG KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK RIKARSRLAE LRGVPRGLYD GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS LSGAQIDDNI PRRTTQRIVA PPGGRANITS LG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
  • 基因功能參考文獻：
    1. postulate that this state forces CRMP2 toward a monomer, exposing the SUMO site and consequently, resulting in constitutive regulation of NaV1.7. PMID: 28277940
    2. These results revealed that bilateral ligation of the internal carotid artery causes retinal ischemia in mice. Moreover, CRMP2 might play a pivotal role during the ischemic injury in the retina and inhibit the cleavage of CRMP2 can ameliorate the IH injury. PMID: 28524835
    3. The findings reveal a critical role for CRMP2 in neuronal plasticity, neural function and behavioral modulation in mice. PMID: 27249678
    4. Results suggested that crmp2 is a target of miR-181c and that the abnormally low expression of miR-181c in the hippocampus of SAMP8 mice could lead to an increase of the crmp2 protein level in Alzheimer's disease mice, which might potentially play a role in the pathogenesis of Alzheimer's disease PMID: 27423553
    5. These results suggest a correlation between CRMP2 phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta accumulation stage in AD model mice. PMID: 27059136
    6. study implies that dysregulation of CRMP2 may be involved in pathophysiology of neuropsychiatric disorders PMID: 27582038
    7. We propose that CRMP2 could contribute to long-lasting synaptic plasticity. PMID: 26250894
    8. This study shows that in young adult mice, motor and sensory functions lost by SCI can be recovered with a single genetic mutation to inhibit CRMP2 phosphorylation PMID: 26795088
    9. Study showed that axon degeneration is an early and dominant feature in dopaminergic neurons treated with 1-methyl-4-phenylpyridiniumion (MPP+), and that the Akt/GSK-3beta/CRMP-2 pathway is involved in axon degeneration induced by MPP+ PMID: 25150591
    10. Clear differences in CRMP2 protein abundance and degradation product/short isoform were observed between ischemic core and penumbra and also compared to the contralateral healthy tissues after PACAP38 or saline treatment. PMID: 25257527
    11. Glycogen synthase kinase 3beta has a role in microtubule remodeling in compensatory glomerular adaptation to podocyte depletion through Tau and CRMP2 PMID: 25468908
    12. Levels of total GSK3 were decreased in the Huntington disease-affected frontal cortex and this correlated with decreased phosphorylated CRMP2. PMID: 24634145
    13. Long-term vitamin E-deficiency led to significantly increased expression of the phosphorylated form of collapsin response mediator protein (CRMP)-2 compared to short-term deficiency. PMID: 24568262
    14. Noncanonical kainate receptor signaling influences neuronal development by modulating CRMP2 activity. PMID: 24227739
    15. a novel regulatory mechanism that utilizes CRMP2 SUMOylation to choreograph NaV1.7 trafficking. PMID: 23836888
    16. A novel glycogen synthase kinasealpha/beta CRMP-2 pathway is identified that connects neuronal activity to dendritic growth. PMID: 23470087
    17. CRMP2 phosphorylation is critical for proper bifurcation of apical dendrite of CA1 pyramidal neurons PMID: 22826151
    18. Two novel matrix metallopeptidase 9 targets were identified: synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 PMID: 22694054
    19. This study demonistrated that phosphorylation of CRMP-2 may be downstream of NgR1 activation and play a role in axonal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. PMID: 22544872
    20. The E3 ligase (ZNRF1)-AKT-glycogen synthase kinase-3beta (GSK3B)-CRMP2 pathway plays an important role in controlling Wallerian degeneration. PMID: 22057101
    21. Activation of CRMP-2 is increased in the hippocampus of transgenic mice at 12 weeks of age when compared with wild-type littermate mice. PMID: 20682295
    22. The phosphorylation of CRMP2 protein, a GSK-3beta substrate that plays a crucial role in Semaphorin3a-mediated axonal guidance. PMID: 16230462
    23. Rho kinase phosphorylates CRMP-2, and inactivates the ability of CRMP-2 to promote microtubule assembly and Numb-mediated endocytosis, during growth cone collapse PMID: 16260611
    24. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. PMID: 16414354
    25. High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation. PMID: 18006081
    26. association of neurofibromin and CRMP-2 is essential for neuronal cell differentiation PMID: 18218617
    27. Hypoxia-ischemia (HI)induces dephosphorylation of CRMPs (CRMP1, 2, and 5) in neonatal brain. Hypophosphorylated CRMPs might be implicated in the pathogenesis of HI-related neurological disorders. PMID: 18471005
    28. We concluded that alterations in neurite maturation resulting from a loss of CLN6-CRMP-2 interaction may contribute to neuronal dysfunction and pathology in vLINCL. PMID: 19235893

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane.
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 數據庫鏈接：


主站蜘蛛池模板： 国语少妇高潮对白在线| а√天堂8资源中文在线| 国产在线视频天天综合网| 高潮爽死抽搐白浆gif视频| 国产高清在线精品一区免费| 乱人伦人妻中文字幕无码久久网| 刺激性视频黄页| 久久綾合久久鬼色88| 国产三级在线观看播放| 久久人人爽人人爽人人片av东京热| 久久99精品国产99久久6不卡 | yy111111少妇无码影院| 中文字幕无码人妻少妇免费| 黑人狠狠的挺身进入| 免费国产精品视频在线| 亚洲老熟女性亚洲| 中文字幕在线免费看线人| 欧美国产日韩a在线观看| 99久久无色码中文字幕人妻| 欧美黑人激情性久久| 免费无码鲁丝片一区二区| 欧美黑人粗大xxxxbbbb| 亚洲精品乱码一区二区三区| 在线а√天堂中文官网| 精品一区二区三区无码免费直播 | 国产a精彩视频精品视频下载| 奇米影视色777四色在线首页| 免费的av网站手机版| 精品影片在线观看的网站| 在线不卡日本v二区到六区| 国产av无码专区亚洲aⅴ| 午夜天堂av天堂久久久| 日本丰满少妇xxxx| 在线人成免费视频69国产| 欧美亚洲精品一区二区| 国产成人一区二区三区别| 欧美高潮喷水大叫| 欧美精品videosbestsex日本| 人人插人人插人人爽| 亚洲性av免费| 免费播放婬乱男女婬视频国产|