在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Dihydroorotate dehydrogenase (quinone),mitochondrial (Dhodh), partial

In Stock
  • 中文名稱:
    小鼠Dhodh重組蛋白
  • 貨號:
    CSB-EP006852MO1
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Dhodh
  • Uniprot No.:
  • 別名:
    Dhodh; Dihydroorotate dehydrogenase; quinone, mitochondrial; DHOdehase; Dihydroorotate oxidase
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    45.0 kDa
  • 表達區域:
    31-395aa
  • 氨基酸序列
    TGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述:

    The preparation of Recombinant Mouse Dhodh protein included 3 main steps: construct the expression vector, expression of protein of interest, and protein purification. Every step was performed under a strict QC system so that we got the premium protein. This Dhodh was expressed in E.coli at and fused with N-terminal 6xHis tag. According to SDS-PAGE, the purity turns out to be 85%+.

    Dhodh is a key enzyme in de novo pyrimidine biosynthesis. the expression level of dihydroorotate dehydrogenase has been reported to be elevated in various types of malignant tumors and its tumor-promoting effect was considered to relate to its pyrimidine synthesis function. Dhodh is the rate-limiting enzyme in the uridine monophosphate (UMP) biosynthetic pathway and mostly located in the inner membrane of mitochondria, catalyzing the transformation of dihydroorotate to orotate dependent of Mg2+ and ATP. Mutations of Dhodh have been associated with various genetic diseases. For example, Dhodh G202A, R346W causes deficient protein stability and R135C impairs the enzymatic activity, which are linked to Miller syndrome. Dhodh polymorphism was reported to be linked with rheumatoid arthritis and lung cancer as well. Additionally, enhanced activity of DHODH has been implicated as a biomarker of malignant tumor including gastric cancer and skin cancer.

  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
  • 基因功能參考文獻:
    1. DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in mouse xenograft studies PMID: 21430780
    2. immunosuppressive agent HR325 (an inhibitor of dihydroorotate dehydrogenase, DHODH) inhibits immunoglobulin (Ig) secretion both in vitro and in vivo and that this effect can be reverse with exogenous uridine PMID: 12100469
    3. Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells of different species PMID: 15571246
  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族:
    Dihydroorotate dehydrogenase family, Type 2 subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲国产成人高清影视| 久久精品中文字幕| 少妇性l交大片毛多| 亚洲精品一区二区玖玖爱| 成人av在线一区二区三区| 巨大乳女人做爰视频在线看| 少妇被粗大猛进进出出| 亚洲精品久久一区二区三区777| 欧美 国产 综合 欧美 视频 | 人摸人人人澡人人超碰97| 五十路熟妇高熟无码视频| 成人区人妻精品一区二区三区 | 天天躁日日躁狠狠躁性色av| 中文字幕人妻偷伦在线视频| 在线视频观看免费视频18| 丰满人妻熟妇乱又伦精品软件| 老熟妻内射精品一区| 国产精品青青青在线观看| 在线观看成人无码中文av天堂不卡 | 男女做爰真人视频直播| 亚洲高清无在码在线电影不卡| 综合久久久久6亚洲综合| 亚洲综合另类小说专区| 亚洲aⅴ男人的天堂在线观看| 精品夜夜爽欧美毛片视频| 四虎永久在线精品免费网址| 精品日本一区二区免费视频| 欧美 亚洲 日韩 中文2019| 鲁大师在线视频播放免费观看 | www插插插无码免费视频网站| 国产欧美精品一区二区三区-老狼| 久久成人影院精品99| 亚洲欧洲综合有码无码| 色妞www精品视频| 美女扒开屁股让男人桶| 欧美成aⅴ人高清怡红院| 久久综合av色老头免费观看| 无码人妻精品一区二区蜜桃色欲| 欧美午夜理伦三级在线观看| 欧美 在线 成 人怡红院| 中国熟妇人妻xxxxx|