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  4. Recombinant Mouse Dihydrofolate reductase (Dhfr)

Recombinant Mouse Dihydrofolate reductase (Dhfr)

  • 中文名稱：
    小鼠Dhfr重組蛋白
  • 貨號：
    CSB-YP006847MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Dhfr重組蛋白
  • 貨號：
    CSB-EP006847MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Dhfr重組蛋白
  • 貨號：
    CSB-EP006847MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Dhfr重組蛋白
  • 貨號：
    CSB-BP006847MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Dhfr重組蛋白
  • 貨號：
    CSB-MP006847MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    DhfrDihydrofolate reductase; EC 1.5.1.3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-187
  • 氨基酸序列
    VRPLNCIVA VSQNMGIGKN GDLPWPPLRN EFKYFQRMTT TSSVEGKQNL VIMGRKTWFS IPEKNRPLKD RINIVLSREL KEPPRGAHFL AKSLDDALRL IEQPELASKV DMVWIVGGSS VYQEAMNQPG HLRLFVTRIM QEFESDTFFP EIDLGKYKLL PEYPGVLSEV QEEKGIKYKF EVYEKKD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA.
  • 基因功能參考文獻：
    1. The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr. PMID: 26830229
    2. S-nitrosylation of DHFR at cysteine 7 by eNOS-derived NO is crucial for DHFR stability. PMID: 26381869
    3. demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme PMID: 25980602
    4. Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin(I27) . PMID: 22162032
    5. protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency PMID: 21402147
    6. Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation PMID: 20424322
    7. E2F-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 lysine 9 PMID: 12588981
    8. translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence PMID: 16107879
    9. mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure PMID: 16183885
    10. Crystal structures are reported for NADPH ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution. PMID: 17019704
    11. Data reveal a key role for dihydrofolate reductase in eNOS coupling by maintaining the tetrahyrobiopterin (BH4):dihydrobiopterin (BH2) ratio, particularly in conditions of low total biopterin availability. PMID: 19666465

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  • 亞細胞定位：
    Mitochondrion. Cytoplasm.
  • 蛋白家族：
    Dihydrofolate reductase family
  • 數據庫鏈接：


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