Recombinant Mouse Dickkopf-related protein 2 (Dkk2)

中文名稱：

小鼠Dkk2重組蛋白
貨號(hào)：

CSB-YP865601MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Dkk2重組蛋白
貨號(hào)：

CSB-EP865601MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dkk2重組蛋白
貨號(hào)：

CSB-BP865601MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Dkk2重組蛋白
貨號(hào)：

CSB-MP865601MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dkk2
Uniprot No.：

Q9QYZ8
別名：

Dkk2; Dickkopf-related protein 2; Dickkopf-2; Dkk-2; mDkk-2
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

34-259
氨基酸序列

KLNSIKS SLGGETPAQS ANRSAGMNQG LAFGGSKKGK SLGQAYPCSS DKECEVGRYC HSPHQGSSAC MLCRRKKKRC HRDGMCCPGT RCNNGICIPV TESILTPHIP ALDGTRHRDR NHGHYSNHDL GWQNLGRPHS KMPHIKGHEG DPCLRSSDCI DGFCCARHFW TKICKPVLHQ GEVCTKQRKK GSHGLEIFQR CDCAKGLSCK VWKDATYSSK ARLHVCQKI
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
基因功能參考文獻(xiàn)：
1. Dkk2 deletion results in alterations of liver morphology leading to an increased frequency of liver cancer PMID: 25826080
2. Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development. PMID: 27053129
3. These findings demonstrate that DKK1 and DKK2 have differential roles in normalization and functionality of tumor blood vessels, in addition to angiogenesis. PMID: 24091497
4. Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation PMID: 23250216
5. Both Dkk1 and Dkk2 inhibit Wnt signaling that regulates early myocardial proliferation; each compensates for loss of the other in that role. PMID: 20439124
6. there are distinct functions of DKK1 and DKK2 in controlling angiogenesis PMID: 21540552
7. Dkk2 was localized in the perichondral mesenchyme outlining the anterior cranial base in embryogenesis. PMID: 16521043
8. Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium PMID: 16672341
9. These data suggest that activation of Dkk2 by PITX2 provides a mechanism to locally suppress canonical Wnt signaling activity during eye development PMID: 18367164
10. analysis of the structural basis of the interaction between Dkk and low density lipoprotein receptor-related protein (LRP) 5/6 PMID: 18524778
11. Dkk2 expression is associated with uterine receptivity changes as well as the process of decidualization and that it might play important roles through inhibition of canonical Wnt signaling in the periimplantation uterus. PMID: 18689976
12. Study identified novel expression domains for the Wnt antagonists Sfrp1, Sfrp3, Sfrp5 as well as Dkk2 and Dkk3. PMID: 19185060
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亞細(xì)胞定位：

Secreted.
蛋白家族：

Dickkopf family
數(shù)據(jù)庫鏈接：

KEGG: mmu:56811

STRING: 10090.ENSMUSP00000029665

UniGene: Mm.103593