在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Desmoglein-3 (Dsg3), partial

Recombinant Mouse Desmoglein-3 (Dsg3), partial

In Stock
  • 中文名稱：
    小鼠Dsg3重組蛋白
  • 品名簡稱：
    Recombinant Mouse Dsg3 protein, partial
  • 貨號：
    CSB-EP007205MOb0
  • 說明書：
  • 規格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Dsg3
  • Uniprot No.：
  • 別名：
    Dsg3Desmoglein-3; 130 kDa pemphigus vulgaris antigen homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    66.9 kDa
  • 表達區域：
    50-617aa
  • 氨基酸序列
    EWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer，50% glycerol
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • 基因功能參考文獻：
    1. flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes PMID: 27346727
    2. Desmoglein 3 deficiency in mice leads to a phenotype characterized by cyclic alopecia in addition to the dramatic skin and mucocutaneous acantholysis observed in pemphigus patients. PMID: 25542773
    3. Dsg3, via p38 MAPK, regulates the spatial distribution of the keratin filament network and stabilizes cell adhesion. PMID: 24782306
    4. Squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in paraneoplastic pemphigus (PNP). PMID: 23729442
    5. Dsg3 deficiency results in perturbation of the desmosomal network at the transcriptional, translational, and interaction level, kinase activation, proteinase-mediated degradation, and hyper-adhesion. (Review) PMID: 23368972
    6. Thus, Dsg3 does not display a clear function as a tumor suppressor in these mouse skin cancer models PMID: 23185521
    7. IgG and IgM antibodies against desmoglein 3 have a pathogenic role in blister formation in pemphigus vulgaris PMID: 21718682
    8. the adult passive transfer mouse model is ideally suited for detailed studies of Dsg3 antibody-mediated signaling in adult skin. PMID: 21956125
    9. These data indicate a contribution of Dsg depletion to pemphigus vulgaris pathogenesis dependent on Ca(2+)-induced differentiation. PMID: 21864491
    10. Aire has an important role in Dsg3 expression as well as in selection of T cells that help B cells to produce anti-Dsg3 IgG in thymus. PMID: 21048786
    11. Loss of tolerance against Dsg3 in both B and T cells is important for the development of autoimmune state of pemphigus vulgaris. PMID: 11857336
    12. Patchy hair loss in pemphigus vulgaris model mice as in Dsg3(-/-) mice. Ultrastructure of telogen hair follicles same as PV model mice and Dsg3(-/-) mice. Anti-Dsg3 autoantibodies interfere with cell-cell adhesion of keratinocytes in PV model mice. PMID: 12373337
    13. perturbation of desmoglein 3 found in the Dsg3bal-Pas mice resulted in disadhesion of keratinocytes manifested with blistering phenotype. PMID: 12485423
    14. anti-Dsg3 IgG antibodies can directly access Dsg3 present in desmosomes in vivo and cause the subsequent desmosome separation that leads to blister formation in pemphigus vulgaris PMID: 15140217
    15. In pemphigus vulgaris antibodies were dominantly raised against middle to C-terminal extracellular domains of mouse Dsg3 where amino acid sequences are less conserved among desmoglein isoforms. Those antibodies may also be involved in blister formation. PMID: 15265525
    16. importance of the companion layer, and particularly the Dsg1 and Dsg3 in this layer, in anchoring the anagen hair to the follicle. PMID: 15482466
    17. Northern Blot analysis of wild-type and Plucked (pk) mutant mice indicates that expression of both desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3) is up-regulated in the skin of mutant pk mice PMID: 15629430
    18. skin-specific Dsg3 serves as an autoantigen in chronic skin inflammatory diseases accompanied by mast cell degranulation, including both murine systemic lupus erythematosus and other autoinflammatory diseases PMID: 16492738
    19. Reduction of Dsg3 might be relevant to blister formation in pemphigus vulgaris. PMID: 17431647
    20. distinct T cell responses could be switched after active immunization combined with different adjuvants, resulting in distinct anti-Dsg3 antibody isotypes with different pathogenic activities in Pemphigus disease development PMID: 18634826
    21. Subcellular localization of desmosomal components is different between desmoglein3 knockout mice and pemphigus vulgaris model mice. PMID: 19525093

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 組織特異性：
    Expressed in epidermis.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产午夜亚洲精品国产成人小说| 久久综合狠狠综合久久综合88| 亚洲精品无码永久在线观看性色 | 巨胸喷奶水视频www免费网站 | 狠狠色噜噜狠狠色综合久| 亚洲欧美日韩成人一区二区三区| 国产亚洲精品久久久久9999| 玩弄丰满奶水的女邻居| 少妇无码av无码专区线y| 2019最新中文字幕在线观看| 精品久久综合1区2区3区激情| 国产精品成人99一区无码| 人人妻人人澡人人爽人人精品av| 日韩成人无码| 最新的国产成人精品2022| 国产欧美一区二区精品仙草咪| 18禁免费吃奶摸下激烈视频| 少妇人妻真实偷人精品视频| 好男人www社区| 在线看片免费人成视频福利| 黑人尾随强伦姧人妻爽翻天 | 无码三级在线看中文字幕完整版| 人人妻人人澡人人爽精品日本| 欧洲成人一区二区三区| 国产人妻久久精品二区三区特黄| 日本高清色www网站色噜噜噜| 成在人线无码aⅴ免费视频| 中国6一12呦女精品| 92国产精品午夜福利| 狠狠色噜噜狠狠狠777米奇小说 | 波多野结衣办公室33分钟| 在线观看特色大片免费网站| 亚洲s码欧洲m码国产av| 日本护士毛茸茸xx| 少妇人妻综合久久中文| 亚洲成a人片在线观看无码| 少妇人妻偷人精品一区二区| 欧美熟妇丰满肥白大屁股免费视频| 欧美日韩人妻精品一区二区在线| 无码日韩精品一区二区三区免费| 欧美刺激性大交|