在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Desmoglein-3 (Dsg3), partial

Recombinant Mouse Desmoglein-3 (Dsg3), partial

  • 中文名稱：
    小鼠Dsg3重組蛋白
  • 貨號：
    CSB-MP007205MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Name:Dsg3
  • Uniprot No.：
  • 別名：
    Dsg3Desmoglein-3; 130 kDa pemphigus vulgaris antigen homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 表達區域：
    50-617
  • 氨基酸序列
    E WVKFAKPCRE REDNSRRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF VVDPNNGDIN ITAIVDREET PSFLITCRAL NALGQDVERP LILTVKILDV NDNPPIFSQT IFKGEIEENS ASNSLVMILN ATDADEPNHM NSKIAFKIVS QEPAGMSMFL ISRNTGEVRT LTSSLDREQI SSYHLVVSGA DNDGTGLSTQ CECSIKIKDV NDNFPVLRES QYSARIEENT LNAELLRFQV TDWDEEYTDN WLAVYFFTSG NEGNWFEIET DPRTNEGILK VVKALDYEQV QSMQFSIAVR NKAEFHQSVI SQYRVQSTPV TIQVIDVREG ISFRPPSKTF TVQRGVSTNK LVGYILGTYQ ATDEDTGKAA SSVRYVLGRN DGGLLVIDSK TAQIKFVKNI DRDSTFIVNK TISAEVLAID ENTGKTSTGT IYVEVPSFNE NCPSVVLEKK DICTSSPSVT LSVRTLDRGK YTGPYTVSLE EQPLKLPVMW TITTLNATSA LLQAQQQVSP GVYNVPVIVK DNQDGLCDTP ESLTLTVCQC DDRSMCRAPI PSREPNTYGE SSWRLGP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • 基因功能參考文獻：
    1. flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes PMID: 27346727
    2. Desmoglein 3 deficiency in mice leads to a phenotype characterized by cyclic alopecia in addition to the dramatic skin and mucocutaneous acantholysis observed in pemphigus patients. PMID: 25542773
    3. Dsg3, via p38 MAPK, regulates the spatial distribution of the keratin filament network and stabilizes cell adhesion. PMID: 24782306
    4. Squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in paraneoplastic pemphigus (PNP). PMID: 23729442
    5. Dsg3 deficiency results in perturbation of the desmosomal network at the transcriptional, translational, and interaction level, kinase activation, proteinase-mediated degradation, and hyper-adhesion. (Review) PMID: 23368972
    6. Thus, Dsg3 does not display a clear function as a tumor suppressor in these mouse skin cancer models PMID: 23185521
    7. IgG and IgM antibodies against desmoglein 3 have a pathogenic role in blister formation in pemphigus vulgaris PMID: 21718682
    8. the adult passive transfer mouse model is ideally suited for detailed studies of Dsg3 antibody-mediated signaling in adult skin. PMID: 21956125
    9. These data indicate a contribution of Dsg depletion to pemphigus vulgaris pathogenesis dependent on Ca(2+)-induced differentiation. PMID: 21864491
    10. Aire has an important role in Dsg3 expression as well as in selection of T cells that help B cells to produce anti-Dsg3 IgG in thymus. PMID: 21048786
    11. Loss of tolerance against Dsg3 in both B and T cells is important for the development of autoimmune state of pemphigus vulgaris. PMID: 11857336
    12. Patchy hair loss in pemphigus vulgaris model mice as in Dsg3(-/-) mice. Ultrastructure of telogen hair follicles same as PV model mice and Dsg3(-/-) mice. Anti-Dsg3 autoantibodies interfere with cell-cell adhesion of keratinocytes in PV model mice. PMID: 12373337
    13. perturbation of desmoglein 3 found in the Dsg3bal-Pas mice resulted in disadhesion of keratinocytes manifested with blistering phenotype. PMID: 12485423
    14. anti-Dsg3 IgG antibodies can directly access Dsg3 present in desmosomes in vivo and cause the subsequent desmosome separation that leads to blister formation in pemphigus vulgaris PMID: 15140217
    15. In pemphigus vulgaris antibodies were dominantly raised against middle to C-terminal extracellular domains of mouse Dsg3 where amino acid sequences are less conserved among desmoglein isoforms. Those antibodies may also be involved in blister formation. PMID: 15265525
    16. importance of the companion layer, and particularly the Dsg1 and Dsg3 in this layer, in anchoring the anagen hair to the follicle. PMID: 15482466
    17. Northern Blot analysis of wild-type and Plucked (pk) mutant mice indicates that expression of both desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3) is up-regulated in the skin of mutant pk mice PMID: 15629430
    18. skin-specific Dsg3 serves as an autoantigen in chronic skin inflammatory diseases accompanied by mast cell degranulation, including both murine systemic lupus erythematosus and other autoinflammatory diseases PMID: 16492738
    19. Reduction of Dsg3 might be relevant to blister formation in pemphigus vulgaris. PMID: 17431647
    20. distinct T cell responses could be switched after active immunization combined with different adjuvants, resulting in distinct anti-Dsg3 antibody isotypes with different pathogenic activities in Pemphigus disease development PMID: 18634826
    21. Subcellular localization of desmosomal components is different between desmoglein3 knockout mice and pemphigus vulgaris model mice. PMID: 19525093

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 組織特異性：
    Expressed in epidermis.
  • 數據庫鏈接：


主站蜘蛛池模板： 日韩亚洲国产激情一区浪潮av| 国产精品成人片在线观看| 97人妻免费碰视频碰免| 男人猛躁进女人免费播放 | 国产女人高潮叫床免费视频| 国产高清在线精品二区| 色婷婷一区二区三区四区成人网| 中文成人无码精品久久久不卡 | 亚洲中久无码永久在线观看同| 免费体验区试看120秒| 日韩高清亚洲日韩精品一区| 无码日韩人妻av一区免费| 爆乳2把你榨干哦ova在线观看| 精品乱码一区二区三区四区 | 色欲天天天综合网| 久久精品aⅴ无码中文字字幕| 5个黑人躁我一个视频| 婷婷色婷婷开心五月| 国产在线观看高清视频黄网| 国产av国片精品jk制服丝袜| 麻豆乱码国产一区二区三区| 久久久久日韩精品免费观看| 国产区在线观看成人精品| 精品无码国产av一区二区三区| 中文字幕精品一区二区精品| 日本高清va在线播放| 亚洲午夜无码久久久久软件| 久久这里只精品国产免费10| 高清不卡毛片免费观看| 亚洲欧美综合精品二区| 色狠狠av老熟女| 欧美色欧美亚洲另类二区| 又黄又湿啪啪响18禁| 国产精品久久久久久久久久红粉 | 中文字幕无码精品亚洲35| 国产麻豆精品久久一二三| 亚洲国产一成人久久精品| 欧美真人性做爰全过程| 人妻少妇heyzo无码专区| 国产欧洲精品自在自线官方| 特级毛片a片久久久久久|