在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse DNA topoisomerase 2-beta (Top2b), partial

Recombinant Mouse DNA topoisomerase 2-beta (Top2b), partial

  • 中文名稱：
    小鼠Top2b重組蛋白
  • 貨號：
    CSB-YP717547MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Top2b重組蛋白
  • 貨號：
    CSB-EP717547MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Top2b重組蛋白
  • 貨號：
    CSB-EP717547MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Top2b重組蛋白
  • 貨號：
    CSB-BP717547MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Top2b重組蛋白
  • 貨號：
    CSB-MP717547MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Top2b
  • Uniprot No.：
  • 別名：
    Top2b; DNA topoisomerase 2-beta; EC 5.6.2.2; DNA topoisomerase II; beta isozyme
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
  • 基因功能參考文獻：
    1. Top2beta controls spinal motor neurons (MN) migration and connectivity; is not required for MN generation or survival; has a selective role in columnar specification. In absence of Top2beta, phrenic MN identity is eroded, while other motor columns are partially preserved but fail to cluster to their proper position. In Top2beta-/- mice, peripheral connectivity is impaired as MNs exhibit a profound deficit in terminal b... PMID: 29379870
    2. our data establish a combinatorial cell-autonomous and non-cell-autonomous role for Top2b in the late stage of photoreceptor differentiation and maturation PMID: 28370415
    3. We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 negatively regulate the XPO1-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis. PMID: 28392395
    4. TOP2beta as a factor involved in regulating granulosa cell genomic integrity and follicle atresia. PMID: 24002654
    5. Results identified topoisomerase IIbeta (Top2beta) as a novel determinant for camptothecin sensitivity. PMID: 23344961
    6. Top IIbeta might be a down-stream target of Nurr1, which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression. PMID: 22296971
    7. Findings suggest a chromatin-based targeting of Top2beta to regulatory regions in the genome to govern the transcriptional program associated with neuronal differentiation and longevity. PMID: 22474351
    8. Data suggest that activity of TOP2B in elongating spermatids is strongly inhibited by PARP1 and PARP2, and this is in turn counteracted by the PAR-degrading activity of PAR glycohydrolase. PMID: 21228215
    9. proteasomal degradation of TOP2beta induced by the TOP2-DNA covalent complex or the TOP2 circular clamp is due to transcriptional arrest but not DNA damage PMID: 12629207
    10. DNA topoisomerase II beta deficiency severely affects cerebral cortex stratification: no subplate is discernible, and neurons born at later stages of corticogenesis fail to migrate to the superficial layers. PMID: 12773624
    11. A nuclear matrix-associated topoisomerase IIB (TOP2B) interacting with an extracellular Mn2+/Ca2+-dependent nuclease cleaves sperm DNA into loop-sized fragments. PMID: 16914690
    12. Results support a role of topoisomerase IIbeta in activation/repression of developmentally regulated genes at late stages of neuronal differentiation. PMID: 16923961
    13. These results suggest that the defect in establishing neuromuscular junctions in top2beta knockout mice could be due to the lack of TopIIbeta-mediated neurite outgrowth. PMID: 17493591
    14. VP-16-induced carcinogenesis involves mainly the beta rather than the alpha isozyme of Top2; VP-16-induced DNA sequence rearrangements and double-strand breaks are found to be Top2beta-dependent PMID: 17578914
    15. NRF-1 can also directly interact with poly(ADP-ribose) polymerase 1 (PARP-1) and co-purify the PARP-1.DNA-PK.Ku80.Ku70.topoisomerase IIbeta-containing protein complex. PMID: 19181665

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
  • 蛋白家族：
    Type II topoisomerase family
  • 數據庫鏈接：


主站蜘蛛池模板： 日日躁夜夜躁狠狠躁超碰97| 天天影视性色香欲综合网| 国产在线精品一区二区三区 | 奇米影视7777久久精品| 老司机亚洲精品影院无码| 欧美大片18禁aaa免费视频| 亚洲免费福利在线视频| 精品免费国产一区二区三区四区介绍| 人人妻人人澡人人爽| 欧美成人精品a∨在线观看| 99re8精品视频热线观看| 国产av一区二区精品久久凹凸| 人妻互换免费中文字幕| 亚洲v国产v欧美v久久久久久| 久久综合色_综合色88| 被拉到野外强要好爽黑人| 亚洲最大天堂无码精品区| 人人爽人人模人人人爽人人爱| 另类亚洲小说图片综合区| 欧美日本精品一区二区三区| 夜鲁鲁鲁夜夜综合视频欧美| 久久精品国产99久久香蕉| 亚洲精品专区成人网站| 亚洲乱码av中文一区二区| 人妻夜夜爽天天爽三区麻豆av网站| 精品国产一二三产品区别在哪| 中文字幕亚洲综合久久青草| 真人作爱免费视频| 国产精品国产三级欧美二区| 国产精华av午夜在线观看| 嫩草av久久伊人妇女超级a| 少妇人妻综合久久中文字幕| 特黄 做受又硬又粗又大视频| 中文字幕久久精品一区二区三区| av小次郎收藏| 蜜臀av午夜一区二区三区| 久久婷婷国产剧情内射白浆| 亚洲日韩亚洲另类| 久久99成人免费| 日韩少妇白浆无码系列| 2021国产成人精品久久|