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  4. Recombinant Mouse DNA repair protein REV1 (Rev1), partial

Recombinant Mouse DNA repair protein REV1 (Rev1), partial

  • 中文名稱：
    小鼠Rev1重組蛋白
  • 貨號：
    CSB-YP852834MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rev1重組蛋白
  • 貨號：
    CSB-EP852834MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rev1重組蛋白
  • 貨號：
    CSB-EP852834MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rev1重組蛋白
  • 貨號：
    CSB-BP852834MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rev1重組蛋白
  • 貨號：
    CSB-MP852834MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Rev1
  • Uniprot No.：
  • 別名：
    Rev1; Rev1l; DNA repair protein REV1; EC 2.7.7.-; Rev1-like terminal deoxycytidyl transferase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
  • 基因功能參考文獻：
    1. These data indicate that dysregulation of cellular Rev1 levels leads to the accumulation of mutations and suppression of cell death, which accelerates the tumorigenic activities of DNA-damaging agents. PMID: 28498946
    2. Rev1 could serve as a backup polymerase in base excision repair and could potentially contribute to activation-induced cytidine deaminase-initiated antibody diversification through this activity. PMID: 27683219
    3. The results support the idea that Rev1 is not essential for the cellular translesion DNA synthesis functions of DNA polymerase zeta in mammalian cells. PMID: 27497692
    4. REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18. PMID: 26795561
    5. Rev1 is essential for the Msh2-independent generation of these transversions downstream of Ung2-induced apyrimidinic sites. PMID: 23857323
    6. Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1(-/-)Msh2(-/-) B cells. PMID: 23140944
    7. REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates. PMID: 22244149
    8. two distinct surfaces of the Rev1 C-terminal domain that separately mediate the assembly of extension and insertion translesion polymerase complexes PMID: 22700975
    9. These results reveal genetic interactions between REV1 catalytic activity and POLH and identify an alternative pathway in the generation of C to G and G to C transversions. PMID: 22223762
    10. REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus. PMID: 22303021
    11. The BRCT domain of Rev1 is involved in regulating DNA replication during the mutagenic bypass of spontaneous and induced DNA lesions. PMID: 15653636
    12. REV1 expression is required for the methyl methanesulfonate induced mutagenesis phenotype of Pol beta null mouse embryonic fibroblast cells. PMID: 15950550
    13. Results indicate a catalytic role of Rev1 in incorporating deoxycytidine residues, most likely opposite abasic nucleotides, during somatic hypermutation. PMID: 16476771
    14. REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated PCNA PMID: 16571727
    15. Here, we report that mouse REV1 can bind directly to PCNA and that monoubiquitylation of PCNA enhances this interaction. PMID: 16857592
    16. REV1 is implicated in the development of carcinogen-induced lung cancer. PMID: 19176310
    17. Rev1-mediated DNA damage bypass at postreplicative gaps quenches irreversible DNA damage responses. PMID: 19332561
    18. role for REV1 in the generation of C:G transitions and A:T mutations suggests that REV1 is involved in multiple mutagenic pathways through functional interaction with other polymerases during the hypermutation pro PMID: 19587019

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    DNA polymerase type-Y family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：


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