在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse DNA repair and recombination protein RAD54-like (Rad54l)

  • 中文名稱:
    小鼠Rad54l重組蛋白
  • 貨號:
    CSB-YP019271MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Rad54l重組蛋白
  • 貨號:
    CSB-EP019271MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Rad54l重組蛋白
  • 貨號:
    CSB-EP019271MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Rad54l重組蛋白
  • 貨號:
    CSB-BP019271MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Rad54l重組蛋白
  • 貨號:
    CSB-MP019271MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Rad54l
  • Uniprot No.:
  • 別名:
    Rad54l; Rad54; DNA repair and recombination protein RAD54-like; EC 3.6.4.-; RAD54 homolog; mHR54; mRAD54
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-747
  • 氨基酸序列
    MRRSLAPSQL ARRKPEDRSS DDEDWQPGTV TPKKRKSSSE TQVQECFLSP FRKPLTQLLN RPPCLDSSQH EAFIRSILSK PFKVPIPNYQ GPLGSRALGL KRAGVRRALH DPLEEGALVL YEPPPLSAHD QLKLDKEKLP VHVVVDPILS KVLRPHQREG VKFLWECVTS RRIPGSHGCI MADEMGLGKT LQCITLMWTL LRQSPECKPE IEKAVVVSPS SLVKNWYNEV EKWLGGRIQP LAIDGGSKDE IDRKLEGFMN QRGARVPSPI LIISYETFRL HVGVLKKGNV GLVICDEGHR LKNSENQTYQ ALDSLNTSRR VLISGTPIQN DLLEYFSLVH FVNSGILGTA HEFKKHFELP ILKSRDAAAS EADRQRGEER LRELIGIVNR CLIRRTSDIL SKYLPVKIEQ VVCCRLTPLQ TELYKRFLRQ AKPEEELREG KMSVSSLSSI TSLKKLCNHP ALIYDKCVAE EDGFEGTLGI FPPGYNSKAV EPQLSGKMLV LDYILAVTRS RSSDKVVLVS NYTQTLDLFE KLCRVRRYLY VRLDGTMSIK KRAKVVERFN SPSSPDFVFM LSSKAGGCGL NLIGANRLVM FDPDWNPAND EQAMARVWRD GQKKICYIYR LLSAGTIEEK IFQRQSHKKA LSSCVVDEEQ DVERHFSLGE LKELFTLDEA SLSDTHDRLH CRRCVNNRQV WPPPDGSDCT SDLAQWNHST DKRGLQDEVL QAAWDASSTA ITFVFHQRSH EEQRGLH
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations.
  • 基因功能參考文獻:
    1. Our study highlights the importance of the cooperation between Rad54 and Mus81 for mediating DNA DSB repair and restraining chromosome missegregation. PMID: 26876210
    2. Rad54 is not required for either transgene isotype switching or transgene hypermutation. PMID: 12218123
    3. Rad54-mediated homologous recombination is not essential for somatic hypermutation. In addition, the finding that the ablation of RAD51 paralogues causes an increase in SHM argues against a direct involvement of HR in promoting SHM. PMID: 12548566
    4. Rad54 has a role in telomere length maintenance PMID: 12897131
    5. Rad54 cooperates with DNA Ligase IV to support cellular proliferation, dna repair, and prevent chromosome and single chromatid aberrations PMID: 15175260
    6. Mus81-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway PMID: 17036055
    7. These results reveal a differential interaction of the ATM-mediated DNA damage response and Rad54 paralog-mediated homologous recombination depending on the DNA damaging agent that initiates the response. PMID: 19061978

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    SNF2/RAD54 helicase family
  • 組織特異性:
    Hardly detectable in most tissues. Dramatically increased in thymus, spleen and testis.
  • 數據庫鏈接:


主站蜘蛛池模板: 最爽爱爱高潮免费视频| 狠狠色噜噜狠狠狠狠蜜桃| 午夜国产亚洲精品一区| 国产无遮挡又黄又爽免费视频| 性生交大片免费看| 国产69久久精品成人看| 精品成人a区在线观看| 偷妻之寂寞难耐2中文字幕| 亚洲综合图色40p| 色五月丁香五月综合五月4438| 亚洲精品色播一区二区| 东京热无码国产精品| 色噜噜狠狠狠综合曰曰曰| www国产精品内射| 无码中字出轨中文人妻中文中 | 欧美高清在线精品一区| 人人爽人人爽人人片a| 午夜免费啪视频在线观看区| 欧美情侣性视频| 极品熟妇大蝴蝶20p| 免费人成视频在线观看播放网站| 亚洲爆乳成av人在线视水卜| 国产sm重味一区二区三区| 欧美性猛交xxxx乱大交极品| 日本道免费精品一区二区| 老子影院无码午夜伦不卡| 人人妻人人妻人人人人妻人人| 亚洲国产精品久久久久久久| 色噜噜狠狠色综合日日| 亚洲毛片无码不卡av在线播放| 精品少妇无码一区二区三批| 播放灌醉水嫩大学生国内精品 | 精品国产av一二三四区| 高h猛烈失禁潮喷无码视频| 暖暖视频 免费 日本社区| 国产成人无码av一区二区| 日产一区日产2区| 国产日韩制服丝袜第一页| 久久精品人人做人人综合| 国产又粗又猛又大爽又黄| 99re6热精品视频在线观看|