在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse DNA-directed DNA/RNA polymerase mu (Polm)

Recombinant Mouse DNA-directed DNA/RNA polymerase mu (Polm)

  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-YP864330MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-EP864330MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-EP864330MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-BP864330MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-MP864330MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Polm
  • Uniprot No.：
  • 別名：
    Polm; polmu; DNA-directed DNA/RNA polymerase mu; Pol Mu; EC 2.7.7.7; Terminal transferase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-496
  • 氨基酸序列
    MLPKRRRVRA GSPHSAVASS TPPSVVRFPD VAIYLAEPRM GRSRRAFLTR LARSKGFRVL DAYSSKVTHV VMEGTSAKEA ICWQKNMDAL PTGCPQPALL DISWFTESMA AGQPVPEEGR HHLEVAEPRK EPPVSASMPA YACQRPSPLT HHNTLLSEAL ETLAEAAGFE ANEGRLLSFS RAASVLKSLP CPVASLSQLH GLPYFGEHST RVIQELLEHG TCEEVKQVRC SERYQTMKLF TQVFGVGVKT ANRWYQEGLR TLDELREQPQ RLTQQQKAGL QYYQDLSTPV RRADAEALQQ LIEAAVRQTL PGATVTLTGG FRRGKLQGHD VDFLITHPEE GQEVGLLPKV MSCLQSQGLV LYHQYHRSHL ADSAHNLRQR SSTMDAFERS FCILGLPQPQ QAALAGALPP CPTWKAVRVD LVVTPSSQFP FALLGWTGSQ FFERELRRFS RQEKGLWLNS HGLFDPEQKR VFHATSEEDV FRLLGLKYLP PEQRNA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
  • 基因功能參考文獻：
    1. Findings demonstrate that Polmu is necessary for proper retinal development, and support that the generation of DNA double-strand breaks and their repair via the non-homologous end-joining pathway are genuine processes involved in neural development. PMID: 27172884
    2. A role for PolMU in the prevention of sarcomagenesis on a murine P53-deficient background was identified. PMID: 28460268
    3. Pol mu and Pol lambda play a key role in conferring on NHEJ the flexibility required for accurate and efficient repair PMID: 26240371
    4. Polmu deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age. PMID: 24691161
    5. DNA polymerase mu has a role in decreased learning and brain long-term potentiation in aged mice PMID: 23301049
    6. These data point to a critical role for pol mu as a global repair player that increases the efficiency and the fidelity of non-homologous end-joining. PMID: 22071146
    7. pronounced senescence in pololymerase mu deficient cells PMID: 20947452
    8. A series of molecular-dynamics simulations with and without the incoming nucleotide in various forms, including mutant systems, based on pol mu's crystal ternary structure, were analyzed. PMID: 21081096
    9. Pol mu is not required for normal Ig gene hypermutation. PMID: 11937519
    10. Pol mu promotes accuracy during Ig kappa recombination. PMID: 16061182
    11. third hypervariable region assumes for each immunoglobulin chain, with pol lambda maintaining a large heavy chain junctional heterogeneity and pol mu ensuring a restricted light chain junctional variability PMID: 16860755
    12. The crystal structure of the polymerase domain of murine Pol mu bound to gapped DNA with a correct dNTP at the active site reveals substrate interactions with side chains in Pol mu that differ from other family X members. PMID: 17159995
    13. Polmu participates in the repair of early-embryo, RAG-induced double-strand breaks and subsequently may contribute to preserve the genomic stability and cellular homeostasis of lymphohematopoietic precursors during development PMID: 19103746
    14. Polm is required for hematopoietic development with an role in maintaining genetic stability in hematopoietic and non-hematopoietic tissues. PMID: 19229323

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    DNA polymerase type-X family
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲 一区二区 在线| 亚洲h在线播放在线观看h| 日本黄页网站免费观看| 精品国产乱码久久久久久下载| 一本色道久久88精品综合| 欧美精品一区二区蜜臀亚洲| 最大胆裸体人体牲交| 一本久久a久久免费精品不卡| 饥渴少妇高潮视频大全| 人妻巨大乳hd免费看| 欧妇女乱妇女乱视频| 久久人人97超碰爱香蕉| awww在线天堂bd资源在线| 精品国产一区二区三区久久| 天天爽夜夜爽夜夜爽精品视频| 亚洲人成电影网站色迅雷| 国模小黎自慰337p人体| 日日碰狠狠躁久久躁婷婷| 色播亚洲视频在线观看| 成人做受视频试看120秒| 免费精品国产自在| 亚洲精品蜜夜内射| 亚洲aⅴ综合色区无码一区| 国产亚洲精品福利视频| 国产人妻大战黑人20p| 欧美成人aaa片一区国产精品| 国产福利男女xx00视频| 成人无码视频免费播放| 国产成人一区二区三区在线| 日本午夜免费啪视频在线| 秋霞国产精品一区二区| 国产亚洲精久久久久久无码| 久久久亚洲欧洲日产国码农村 | 亚洲精品久久久久久久观小说 | 国产做a爰片久久毛片a片白丝| 国产办公室秘书无码精品99| 精品无码一区二区三区| 西西人体扒开下部试看120秒| 国产大量精品视频网站| 两个黑人大战嫩白金发美女| 狠狠色丁香婷婷综合|