在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse DNA-directed DNA/RNA polymerase mu (Polm)

Recombinant Mouse DNA-directed DNA/RNA polymerase mu (Polm)

  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-YP864330MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-EP864330MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-EP864330MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-BP864330MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Polm重組蛋白
  • 貨號：
    CSB-MP864330MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Polm
  • Uniprot No.：
  • 別名：
    Polm; polmu; DNA-directed DNA/RNA polymerase mu; Pol Mu; EC 2.7.7.7; Terminal transferase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-496
  • 氨基酸序列
    MLPKRRRVRA GSPHSAVASS TPPSVVRFPD VAIYLAEPRM GRSRRAFLTR LARSKGFRVL DAYSSKVTHV VMEGTSAKEA ICWQKNMDAL PTGCPQPALL DISWFTESMA AGQPVPEEGR HHLEVAEPRK EPPVSASMPA YACQRPSPLT HHNTLLSEAL ETLAEAAGFE ANEGRLLSFS RAASVLKSLP CPVASLSQLH GLPYFGEHST RVIQELLEHG TCEEVKQVRC SERYQTMKLF TQVFGVGVKT ANRWYQEGLR TLDELREQPQ RLTQQQKAGL QYYQDLSTPV RRADAEALQQ LIEAAVRQTL PGATVTLTGG FRRGKLQGHD VDFLITHPEE GQEVGLLPKV MSCLQSQGLV LYHQYHRSHL ADSAHNLRQR SSTMDAFERS FCILGLPQPQ QAALAGALPP CPTWKAVRVD LVVTPSSQFP FALLGWTGSQ FFERELRRFS RQEKGLWLNS HGLFDPEQKR VFHATSEEDV FRLLGLKYLP PEQRNA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
  • 基因功能參考文獻：
    1. Findings demonstrate that Polmu is necessary for proper retinal development, and support that the generation of DNA double-strand breaks and their repair via the non-homologous end-joining pathway are genuine processes involved in neural development. PMID: 27172884
    2. A role for PolMU in the prevention of sarcomagenesis on a murine P53-deficient background was identified. PMID: 28460268
    3. Pol mu and Pol lambda play a key role in conferring on NHEJ the flexibility required for accurate and efficient repair PMID: 26240371
    4. Polmu deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age. PMID: 24691161
    5. DNA polymerase mu has a role in decreased learning and brain long-term potentiation in aged mice PMID: 23301049
    6. These data point to a critical role for pol mu as a global repair player that increases the efficiency and the fidelity of non-homologous end-joining. PMID: 22071146
    7. pronounced senescence in pololymerase mu deficient cells PMID: 20947452
    8. A series of molecular-dynamics simulations with and without the incoming nucleotide in various forms, including mutant systems, based on pol mu's crystal ternary structure, were analyzed. PMID: 21081096
    9. Pol mu is not required for normal Ig gene hypermutation. PMID: 11937519
    10. Pol mu promotes accuracy during Ig kappa recombination. PMID: 16061182
    11. third hypervariable region assumes for each immunoglobulin chain, with pol lambda maintaining a large heavy chain junctional heterogeneity and pol mu ensuring a restricted light chain junctional variability PMID: 16860755
    12. The crystal structure of the polymerase domain of murine Pol mu bound to gapped DNA with a correct dNTP at the active site reveals substrate interactions with side chains in Pol mu that differ from other family X members. PMID: 17159995
    13. Polmu participates in the repair of early-embryo, RAG-induced double-strand breaks and subsequently may contribute to preserve the genomic stability and cellular homeostasis of lymphohematopoietic precursors during development PMID: 19103746
    14. Polm is required for hematopoietic development with an role in maintaining genetic stability in hematopoietic and non-hematopoietic tissues. PMID: 19229323

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    DNA polymerase type-X family
  • 數據庫鏈接：


主站蜘蛛池模板： 婷婷成人五月综合激情| 亚洲精品卡2卡三卡4卡2卡乱码| 综合无码精品人妻一区二区三区 | 精品国产高清毛片a片看| 精品无码国产av一区二区三区| 国产无遮挡又黄又爽又色| 国产初高中生粉嫩无套第一次 | 亚洲中文字幕无码中字| 亚洲一区二区女搞男| 女m羞辱调教视频网站| av无码天一区二区一三区| 无码中文字幕日韩专区视频| 欧美大黑帍在线播放| 久久精品人成免费| 顶级少妇做爰视频在线观看| 亚洲日韩中文字幕一区| 风韵人妻丰满熟妇老熟女| 国产成+人欧美+综合在线观看| 国产精品久久久久aaaa| 精品人妻大屁股白浆无码| 国产情侣大量精品视频| 国产精品无码一区二区在线看| 欧美成人猛片aaaaaaa| 精品国产18久久久久久| 久久久精品久久久久久96| 韩国 日本 亚洲 国产 不卡| 日日碰狠狠添天天爽无码| 日本高清视频www夜色资源| 国产v综合v亚洲欧| 亚洲精品一区二区三区影院| 亚洲乱码中文字幕综合| 亚洲国产成人av片在线播放| 色偷偷偷久久伊人大杳蕉| 野花社区视频www官网| 国产特级毛片aaaaaa| 亚洲中文有码字幕日本| 国产人成视频在线观看| 欧美 丝袜 自拍 制服 另类| 日本国产成人国产在线播放 | 又色又爽又黄的视频软件app| 久久久噜噜噜久噜久久|