在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Cysteine protease ATG4B (Atg4b)

  • 中文名稱:
    Recombinant Mouse Cysteine protease ATG4B(Atg4b)
  • 貨號(hào):
    CSB-YP807332MO
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse Cysteine protease ATG4B(Atg4b)
  • 貨號(hào):
    CSB-EP807332MO-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse Cysteine protease ATG4B(Atg4b)
  • 貨號(hào):
    CSB-BP807332MO
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse Cysteine protease ATG4B(Atg4b)
  • 貨號(hào):
    CSB-MP807332MO
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Atg4b; Apg4b; Autl1; Kiaa0943Cysteine protease ATG4B; EC 3.4.22.-; AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-393
  • 氨基酸序列
    MDAATLTYDT LRFAEFEDFP ETSEPVWILG RKYSIFTEKD EILSDVASRL WFTYRRNFPA IGGTGPTSDT GWGCMLRCGQ MIFAQALVCR HLGRDWRWTQ RKRQPDSYFN VLNAFLDRKD SYYSIHQIAQ MGVGEGKSIG QWYGPNTVAQ VLKKLAVFDT WSSLAVHIAM DNTVVMEEIR RLCRANLPCA GAAALPTDSE RHCNGFPAGA EVTNRPSAWR PLVLLIPLRL GLTDINEAYV ETLKHCFMMP QSLGVIGGKP NSAHYFIGYV GEELIYLDPH TTQPAVELTD SCFIPDESFH CQHPPSRMGI GELDPSIAVG FFCKTEEDFN DWCQQVKKLS QLGGALPMFE LVEQQPSHLA CQDVLNLSLD SSDVERLERF FDSEDEDFEI LSL
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
  • 基因功能參考文獻(xiàn):
    1. At the microtubule-actin crossover junction, ATG4B detaches LC3B from melanosomal membranes by enzymatic delipidation. PMID: 28598240
    2. ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 PMID: 28287329
    3. miR-34a might regulate the autophagic activity and can cause injury in ischemia reperfusion injured renal tubular epithelial cells (RTEC) via targeting Atg4B. Atg4B knockdown inhibited autophagy in RTECs. PMID: 26406385
    4. the ATG4B protease and autophagy play a crucial role protecting epithelial cells against bleomycin-induced stress and apoptosis PMID: 25906080
    5. REDD1/TXNIP complex expression is sufficient to induce reactive oxygen species, suppress ATG4B activity and activate autophagy. PMID: 25916556
    6. these findings demonstrate a role for Ser-383 and Ser-392 phosphorylation of ATG4B in control of autophagy. PMID: 26378241
    7. mTOR inhibition alleviates Huntington's disease progression by inducing Atg4b-dependent autophagic flux. PMID: 23861892
    8. An autophagy-related gene, Atg4b, is identified as a de novo target gene of C/EBP BETA and is shown to play an important role in 3T3-L1 adipocyte differentiation. PMID: 23754749
    9. The Atg4b participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane. PMID: 22055344
    10. Genetic inactivation of mouse Atg4b resulted in amorphous globular bodies in the neuropil of the deep cerebellar nuclei and adjacent vestibular nuclei and a mild but measurable impairment of motor performance on the Rotarod. PMID: 20634410
    11. The Apg4B/autophagin-1 protease thus serves as a processing/deconjugating enzyme for these four highly divergent mammalian Apg8 homologues, GATE-16, MAP1-LC3, GABARAP, and Apg8L. PMID: 14530254
    12. These results show that the lipidation of LC3 paralogues is involved in the completion of autophagosome formation in mammalian cells. PMID: 18768752

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    Peptidase C54 family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 99尹人香蕉国产免费天天| 中文字幕无码日韩中文字幕| 国产在线拍揄自揄拍无码视频| 久久婷婷国产综合精品| 在线观看欧美一区二区三区| 水蜜桃精品一二三| 国产成人无码a区在线观看视频免费| 青青草原综合久久大伊人精品| 亚洲色婷婷久久精品av蜜桃久久 | 国产伦子沙发午休系列资源曝光| 青草影院内射中出高潮| 日韩制服国产精品一区| 国产精品白浆无码流出视频| 少妇扒开粉嫩小泬视频| 亚洲动漫精品无码av天堂| 国产午精品午夜福利757视频播放| 九色porny丨自拍视频| 免费看成人啪啪| 玖玖资源站最稳定网址| 免费啪视频在线观看视频日本| 人人人妻人人人妻人人人| 欧洲国产伦久久久久久久| 亚洲日韩在线中文字幕线路2区| 亚洲人成人无码www| 国产激情电影综合在线看| 40岁成熟女人牲交片20分钟| 日产亚洲一区二区三区| 久久婷婷狠狠综合激情| 欧美专区另类专区在线视频| 中文字幕人妻中文av不卡专区| 亚洲精品国产精品乱码不99| 欧美综合自拍亚洲综合区| 国产欧美日韩中文久久| 亚洲精品亚洲人成人网| 中文字幕无码日韩欧免费软件| 日本少妇寂寞少妇aaa| 亚洲精品成人区在线观看| 少妇内射兰兰久久| 亚洲国产欧美在线成人app| 久久免费看少妇高潮v片特黄| 天堂在线中文网www|