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  4. Recombinant Mouse Copper-transporting ATPase 2 (Atp7b), partial

Recombinant Mouse Copper-transporting ATPase 2 (Atp7b), partial

  • 中文名稱：
    Recombinant Mouse Copper-transporting ATPase 2(Atp7b) ,partial
  • 貨號：
    CSB-YP723743MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Copper-transporting ATPase 2(Atp7b) ,partial
  • 貨號：
    CSB-EP723743MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Copper-transporting ATPase 2(Atp7b) ,partial
  • 貨號：
    CSB-EP723743MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Copper-transporting ATPase 2(Atp7b) ,partial
  • 貨號：
    CSB-BP723743MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Copper-transporting ATPase 2(Atp7b) ,partial
  • 貨號：
    CSB-MP723743MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Atp7b; WndCopper-transporting ATPase 2; EC 7.2.2.8; Copper pump 2; Wilson disease-associated protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
  • 基因功能參考文獻(xiàn)：
    1. This study showed that knockout of Atp7b led to altered lipid metabolism and liver steatosis in the absence of inflammation. PMID: 28428350
    2. ATP7B is transported from the trans-Golgi network (TGN) to the bile canaliculus by basolateral sorting and endocytosis, and microtubule-mediated transcytosis through the subapical compartment. PMID: 27034138
    3. Data indicate that the copper-transporting ATPase gene (Atp7b) knockout mice showed a drastic, time-dependent accumulation of hepatic copper. PMID: 25704483
    4. The aim of this study was to identify copper disturbances according to various brain compartments and further dissect the causal relationship between copper storage and neuronal damage using Atp7b(-/-) mice. PMID: 25594375
    5. DKWSLLL sequence is essential for ATP7b sorting at the TGN, transport from the TGN to the PM, endocytosis, and recycling to the TGN and PM. PMID: 24831241
    6. Ligand-activated nuclear receptors FXR/NR1H4 and GR/NR3C1 and nuclear receptor interacting partners are less abundant in Atp7b(-/-) hepatocyte nuclei. PMID: 22565294
    7. By performing dynamic PET, authors obtained the first real-time measurements of 64Cu distribution in the organs or tissues of Atp7b -/- mice. PMID: 21327972
    8. Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease. PMID: 21517843
    9. The Jackson toxic milk mouse as a model for copper loading PMID: 11668395
    10. Both Atp7a and Atp7b are expressed in glomeruli; however, Atp7b is also seen in the kidney medulla suggesting that glomeruli are responsible for regulating copper levels in the filtrate PMID: 12372948
    11. In mice in which this enzyme has been knocked out, the is a reduced level of beta-hydroxylase and norepinephrine in the adrenal gland. PMID: 12718440
    12. Mice homozygous for the recessive txJ mutation examined at 6 months of age exhibited a reduced number of amyloid plaques and diminished plasma Abeta levels. Homozygosity for txJ increased survival and lowered endogenous CNS Abeta. PMID: 14617772
    13. in Atp7b-/- mice elevated copper affects specific cellular targets at the transcription and/or translation levels and has distinct effects on liver metabolic function, prior to appearance of histopathological changes PMID: 17205981
    14. Studies using polarized PMC42-LA cells that overexpressed mAtp7B protein showed that this transporter facilitates copper efflux from the apical surface of the cells. PMID: 18180385
    15. cisplatin binding to ATP7B and/or general changes in cellular copper homeostasis are likely contributors to the increased resistance to the drug. PMID: 19141620

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  • 相關(guān)疾病：
    Defects in Atp7b are the cause of the toxic milk mouse mutant (tx) phenotype, characterized by accumulation of copper in the liver in a manner similar to that observed in patients with Wilson disease.
  • 亞細(xì)胞定位：
    Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily
  • 組織特異性：
    Detected in liver and kidney.
  • 數(shù)據(jù)庫鏈接：


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