在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Complexin-2 (Cplx2)

  • 中文名稱(chēng):
    Recombinant Mouse Complexin-2(Cplx2)
  • 貨號(hào):
    CSB-YP005894MO
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱(chēng):
    Recombinant Mouse Complexin-2(Cplx2)
  • 貨號(hào):
    CSB-EP005894MO
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱(chēng):
    Recombinant Mouse Complexin-2(Cplx2)
  • 貨號(hào):
    CSB-EP005894MO-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱(chēng):
    Recombinant Mouse Complexin-2(Cplx2)
  • 貨號(hào):
    CSB-BP005894MO
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱(chēng):
    Recombinant Mouse Complexin-2(Cplx2)
  • 貨號(hào):
    CSB-MP005894MO
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Cplx2Complexin-2; 921-L; Complexin II; CPX II; Synaphin-1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度:
    Full length protein
  • 表達(dá)區(qū)域:
    1-134
  • 氨基酸序列
    MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis. Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain.
  • 基因功能參考文獻(xiàn):
    1. We describe a high degree of structural similarity between the CpxII CTD and the SNAP25-SN1 domain (C-terminal half) and show that the CTD peptide lowers the rate of SDS-resistant SNARE complex formation in vitro. Moreover, corresponding CpxII:SNAP25 chimeras do restore complexin's function and even 'superclamp' tonic secretion. PMID: 30044227
    2. Complexin II is a central target molecule that links NADPH oxidase-derived reactive oxygen species to glutamate-mediated neuronal excitotoxicity in ischemic stroke. PMID: 23982049
    3. CpxII attenuates fluctuations of the early fusion pore and slows its expansion. PMID: 24687280
    4. Cplx2 knockout mice exhibit hyperlocomotion following neonatal isolation stress. PMID: 21861047
    5. Several months after lesion, Cplx2 null mutants showed reduced pre-pulse inhibition, deficit of spatial learning and loss of inhibition after MK-801 challenge. PMID: 20412316
    6. Complexin 2 knockout mice show significant abnormalities in cognitive function and synaptic plasticity. PMID: 20584925
    7. We found an early and progressive decrease of CPLXII expression in R6/2 mice brains. In contrast, no changes in SNARE expression were seen in R6/2 brains compared with wild type brain. PMID: 15121238
    8. stabilization of SNARE interactions by complexin is an essential aspect of the regulated trafficking events that increase apical membrane epithelial sodium channel density either by constitutive or regulated trafficking pathways PMID: 15972388
    9. CPXs regulate the size of the primed vesicle pools and have a positive role in Ca(2+)-triggered exocytosis in chromaffin cells PMID: 19033464

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytosol. Cell junction, synapse, presynapse. Nucleus. Perikaryon.
  • 蛋白家族:
    Complexin/synaphin family
  • 組織特異性:
    Nervous system. Expressed predominantly in brain, where it is present in many regions, including hippocampus and cerebellum. In the retina, present at conventional amacrine cell synapses (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 精品无码欧美黑人又粗又| 一区二区三区在线 | 欧洲| 蜜芽久久人人超碰爱香蕉| 四虎国产精品永久入口| 久久亚洲色www成人男男| 亚洲欧美国产免费综合视频| 无套内谢的新婚少妇国语播放| 欧美金妇欧美乱妇xxxx| 日本免码va在线看免费| 在线天堂最新版资源| 18禁黄网站禁片免费观看| 99久久国语露脸精品国产| 亚洲va在线va天堂xxxx| 思思99热久久精品在线6| 三级4级全黄60分钟| 不卡无码av一区二区三区| 女人被躁到高潮免费视频软件| 大色综合色综合网站| 国产成人a∨激情视频厨房| 免费无码av片在线观看播放| 乱人伦无码中文视频在线| av无码国产在线看免费网站| 精品无码国产av一区二区三区| 在线观看国产精品电影| 国产成+人+综合+亚洲专区| 在线 | 国产精品星空传媒丿| 精品国产一区二区三区香蕉| 好了av四色综合无码久久| 日本熟妇厨房xxxxx乱| 无套中出极品少妇白浆| 亚洲国产成人精品久久久| 巨大乳做爰视频在线看| 伊人久久大香线蕉无码不卡| 欧美成人免费一区二区| 婷婷五月综合激情中文字幕| 无人区一线二线三线乱码| 国产凹凸在线一区二区| 中国凸偷窥xxxx自由视频妇科| 一区二区视频传媒有限公司| 免费乱码人妻系列无码专区| 成人欧美一区二区三区黑人|