在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Collagen alpha-3 (IV) chain (Col4a3), partial

Recombinant Mouse Collagen alpha-3 (IV) chain (Col4a3), partial

  • 中文名稱：
    Recombinant Mouse Collagen alpha-3(IV) chain(Col4a3) ,partial
  • 貨號：
    CSB-YP865615MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Collagen alpha-3(IV) chain(Col4a3) ,partial
  • 貨號：
    CSB-EP865615MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Collagen alpha-3(IV) chain(Col4a3) ,partial
  • 貨號：
    CSB-BP865615MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Collagen alpha-3(IV) chain(Col4a3) ,partial
  • 貨號：
    CSB-MP865615MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Col4a3Collagen alpha-3(IV) chain [Cleaved into: Tumstatin]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.
  • 基因功能參考文獻：
    1. The quality and quantity of alpha3IV-NC1-specific Ab and T cell responses are critical for the phenotype of the glomerulonephritis. PMID: 25769923
    2. Report novel mouse model of Alport syndrome with accumulation abnormal collagen alpha3alpha4alpha5(IV) trimers in the glomerular basement membrane. PMID: 24522496
    3. Report monoclonal antibody against the collagen type IV alpha3NC1 domain as a marker for glomerular disease. PMID: 23515049
    4. Data show that deletion of tumstatin and TSP1 in p53-/- mice leads to increased tumor burden and reduced survival. PMID: 21622854
    5. the pathogenetic role of USAG-1 in Col4a3-/- mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 may be a promising therapeutic approach for the treatment of Alport syndrome. PMID: 20197625
    6. Collagen alpha3(IV) nor alpha4(IV) were detected in the lens capsule 2 weeks postnatal. PMID: 12225806
    7. Matrix metalloproteinase-9 generated fragments of procollagen, type IV, alpha 3 has endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth. PMID: 12842087
    8. Alpha3(IV), alpha4(IV), and alpha5(IV) chains form a complex, which is a heterotrimer, and a defect in complex formation might be one of the molecular mechanisms underlying the pathogenesis of Alport syndrome. PMID: 14633121
    9. Upregulation of Lama5 transcription and concentration of laminin alpha1 and alpha5 within (Alport)collagen alpha3(IV) knockout glomerular basement membrane thickenings contribute to abnormal permeabilities. PMID: 17699809
    10. Collagen alpha 3 alpha 4 alpha 5(IV) originates solely from podocytes; therefore, glomerular Alport disease is a genetic defect that manifests specifically within this cell type. PMID: 19423686
    11. A single immunization of highly denatured recombinant mouse collagen IV alpha 3 chain noncollagen domain induces severe glomerulonephritis in 100% of Wistar Kyoto rats. PMID: 11490029

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 蛋白家族：
    Type IV collagen family
  • 組織特異性：
    Highly expressed in kidney and lung. Detected at lower levels in heart, muscle and skin.
  • 數據庫鏈接：


主站蜘蛛池模板： 中文字幕日韩人妻不卡一区| 无人区码一码二码w358cc| 中文字幕卡二和卡三的视频| 日韩精品无码人妻一区二区三区| 久久午夜无码鲁丝片直播午夜精品 | 精品久久久久久久久久久国产字幕 | 老子影院午夜伦不卡无码| 嫩草av久久伊人妇女超级a| 国产精品熟女高潮视频| 免费无遮挡无码视频网站| 国内精品国语自产拍在线观看| 永久中文字幕免费视频网站 | 精品国内在视频线2019| 亚洲无线码在线一区观看 | 狠狠狠狼鲁亚洲综合网| av亚欧洲日产国码无码| 色一情一乱一乱一区99av| 浓毛欧美老妇乱子伦视频| 激情内射亚洲一区二区三区爱妻| 国产精品日日做人人爱| 一本久久a久久免费精品不卡| 国产乱子伦精品免费视频| 国产萌白酱喷水视频在线观看| 人人超人人超碰超国产97超碰| 亚洲色欲久久久久综合网| 一本av高清一区二区三区| 婷婷综合缴情亚洲| 妺妺窝人体色www看人体| 少妇性l交大片| 国产午夜精品一区二区三区极品 | 国产成人a在线观看视频| 曰本无码人妻丰满熟妇啪啪| 老子午夜精品无码| 亚洲精品综合一区二区三| 亚洲人成网77777亚洲色| 欧美xxxx做受性欧美88| 7777精品久久久大香线蕉| 无码专区亚洲制服丝袜| 66亚洲一卡2卡新区成片发布| 免费国产a国产片高清| 老司机午夜精品视频资源 |