在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Collagen alpha-2 (VIII) chain (Col8a2)

  • 中文名稱:
    Recombinant Mouse Collagen alpha-2(VIII) chain(Col8a2)
  • 貨號:
    CSB-YP005756MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse Collagen alpha-2(VIII) chain(Col8a2)
  • 貨號:
    CSB-EP005756MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Mouse Collagen alpha-2(VIII) chain(Col8a2)
  • 貨號:
    CSB-EP005756MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse Collagen alpha-2(VIII) chain(Col8a2)
  • 貨號:
    CSB-BP005756MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse Collagen alpha-2(VIII) chain(Col8a2)
  • 貨號:
    CSB-MP005756MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Col8a2
  • Uniprot No.:
  • 別名:
    Col8a2Collagen alpha-2(VIII) chain; Endothelial collagen
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    25-699
  • 氨基酸序列
    GGGAGG AAGYAPVKYV QPMQKGPVGP PFREGKGQYL EMPLPMLPMD LKGEPGPPGK PGPRGPPGPP GFPGKPGTGK PGVHGQPGPA GPPGFSRMGK AGPPGLPGKV GPPGQPGLRG EPGIRGDQGL RGPPGPPGLP GPSGITVPGK PGAQGAPGPP GFRGEPGPQG EPGPRGDRGL KGDNGVGQPG LPGAPGQAGA PGPPGLPGPA GLGKPGLDGI PGAPGDKGDS GPPGVPGSRG EPGAVGPKGP PGVDGVGIPG AAGVPGPQGP VGAKGEPGLR GPPGLIGPVG YGMPGKPGPK GDRGPVGAPG LLGDRGEPGE DGKPGEQGPQ GLGGPPGLPG SAGLPGRRGP PGSKGEVGPG GPPGVPGIRG DQGPNGLAGK PGLPGERGLP GAHGPPGPTG PKGEPGFTGR PGGPGVAGAL GQKGDLGLPG QPGLRGPSGI PGLQGPAGPI GPQGLPGLKG EPGLPGPPGE GKVGEPGSAG PTGPPGVPGS PGLTGPPGPP GPPGPPGAPG ALDETGIAGL HLPNGGVEGA VLGKGGKPQF GLGELSAHAT PAFTAVLTSP FPASGMPVRF DRTLYNGHSG YNPATGIFTC PVGGVYYFAY HVHVKGTNVW VALYKNNVPA TYTYDEYKKG YLDQASGGAV LQLRPNDQVW VQMPSDQANG LYSTEYIHSS FSGFLLCPT
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
  • 基因功能參考文獻:
    1. Overexpression of the Col8a2 gene in mouse and human Fuchs endothelial corneal dystrophy endothelial cells suggested a role for altered autophagy in this disease. PMID: 23422828
    2. in contrast to diabetic wild-type mice EMT-like changes were attenuated in diabetic Col8alpha1/alpha2-KO mice, indicating that collagen VIII may be 1 of the major inducers of epithelial-to-mesenchymal transition-like changes in kidneys of diabetic wild-type mice PMID: 22759394
    3. study confirms the Q455K substitution in the COL8A2 gene as being sufficient to cause FECD in the first mouse model of this disease and supports the role of the UPR and UPR-associated apoptosis in the pathogenesis of FECD caused by COL8A2 mutations PMID: 22002996
    4. Type VIII collagen significantly modulates the effect of TGF-beta1 on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy. PMID: 21372207
    5. Smooth muscle cells can modify the matrix microenvironment by producing type VIII collagen, using it to overlay type I collagen, and generating a substrate favorable for migration PMID: 16269661
    6. Lack of type VIII collagen confers renoprotection in diabetic nephropathy in a knockout mouse model. PMID: 19401424
    7. The mouse mutant Aca23 described here offers the first point mutation of the Col8a2 gene and suggests that a functional collagen VIII alpha2 gene is essential for the correct assembly of the Descemet's membrane and for corneal stability. PMID: 19578028

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 組織特異性:
    In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells.
  • 數據庫鏈接:


主站蜘蛛池模板: 欧美精品中文字幕亚洲专区| 成人午夜福利视频| 国产精品婷婷久久爽一下| 国产成人亚洲精品| 在线播放人成视频观看| 五月激情婷婷丁香综合基地| 三上悠亚ssⅰn939无码播放| 国产午夜伦鲁鲁| 欧美videos另类极品| 精品久久久久中文字幕app| 国产又大又硬又粗| 青青爽无码视频在线观看| 国产免费又黄又爽又色毛| 天天躁日日躁狠狠躁av麻豆男男 | 中文字幕av无码不卡| 在线亚洲日产一区二区| 四虎国产精品永久地址49| 中文字幕人妻熟女人妻| 日本熟妇人妻xxxxx| 色综合 图片区 小说区| 亚洲日韩精品国产一区二区三区| 亚洲熟女av综合网五月| 国产精品美女被遭强扒开双腿| 色偷偷噜噜噜亚洲男人| 97国产精东麻豆人妻电影| 午夜亚洲乱码伦小说区69堂| 2021无码天堂在线| 中文字幕亚韩| 亚洲精品国产精品乱码视色| 国产av一区二区精品凹凸| 欧美又黄又大又爽a片三年片| 丰满少妇人妻无码专区| 亚洲中文字幕无码爆乳app| 国产av一区二区三区无码野战| 最近2019中文字幕在线| 成av人片一区二区三区久久| 国产婷婷成人久久av免费高清| 欧美黑人又粗又硬xxxxx喷水| 日本一区二区无卡高清视频| 亚洲自偷自拍另类小说| 青青草97国产精品免费观看|