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  4. Recombinant Mouse Collagen alpha-1 (V) chain (Col5a1), partial

Recombinant Mouse Collagen alpha-1 (V) chain (Col5a1), partial

  • 中文名稱：
    Recombinant Mouse Collagen alpha-1(V) chain(Col5a1) ,partial
  • 貨號：
    CSB-YP005748MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Collagen alpha-1(V) chain(Col5a1) ,partial
  • 貨號：
    CSB-EP005748MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Collagen alpha-1(V) chain(Col5a1) ,partial
  • 貨號：
    CSB-EP005748MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Collagen alpha-1(V) chain(Col5a1) ,partial
  • 貨號：
    CSB-BP005748MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Collagen alpha-1(V) chain(Col5a1) ,partial
  • 貨號：
    CSB-MP005748MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Col5a1Collagen alpha-1(V) chain
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Transcriptionally activated by CEBPZ, which recognizes a CCAAT-like motif, CAAAT in the COL5A1 promoter.
  • 基因功能參考文獻：
    1. COL5A1 may contribute the metastasis of lung adenocarcinoma. PMID: 29702185
    2. Significantly decreased fibroblast proliferation was observed in Col5a1(+/-) compared to Col5a1(+/+) fibroblasts. PMID: 26713685
    3. Col5a1 knockout stroma demonstrated severe dysfunctional regulation of fibrillogenesis. PMID: 22159420
    4. Sp7/Osterix was observed to participate in the activation of the Col5a1 promoter during osteoblast differentiation. PMID: 20888414
    5. Col(V) is an established autoantigen in atherosclerotic mice, and Col(V) autoimmunity is a consistent feature, with variable T helper type (Th)1 cell pathway involvement. PMID: 20814021
    6. analysis of processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer PMID: 15136578
    7. CBF activated the Col5a1 promoter suggesting that CBF is a key factor in the coordinated expression of type I and V collagen genes PMID: 15246108
    8. collagen type V has a critical role in early fibril initiation PMID: 15383546
    9. COL5A1 is regulated by TGF-beta in osteoblasts PMID: 15579311
    10. col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages PMID: 16492673
    11. Type V collagen contributes to the development of functional connective tissues during embryogenesis. PMID: 17024418
    12. ColVa1+/- and ColXIa1-/- mutants were used to identify roles for ColVa1 and ColXIa1 in ventricular myocardial morphogenesis and heart valve development. PMID: 17029294

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  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibrillar collagen family
  • 組織特異性：
    Widely expressed. Isoform 2 is more highly expressed in liver, kidney and lung.
  • 數據庫鏈接：

    KEGG: mmu:12831

    STRING: 10090.ENSMUSP00000028280

    UniGene: Mm.7281



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