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  4. Recombinant Mouse Chromodomain-helicase-DNA-binding protein 7 (Chd7), partial

Recombinant Mouse Chromodomain-helicase-DNA-binding protein 7 (Chd7), partial

  • 中文名稱：
    Recombinant Mouse Chromodomain-helicase-DNA-binding protein 7(Chd7) ,partial
  • 貨號：
    CSB-YP005332MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Chromodomain-helicase-DNA-binding protein 7(Chd7) ,partial
  • 貨號：
    CSB-EP005332MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Chromodomain-helicase-DNA-binding protein 7(Chd7) ,partial
  • 貨號：
    CSB-EP005332MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Chromodomain-helicase-DNA-binding protein 7(Chd7) ,partial
  • 貨號：
    CSB-BP005332MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Chromodomain-helicase-DNA-binding protein 7(Chd7) ,partial
  • 貨號：
    CSB-MP005332MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Chd7Chromodomain-helicase-DNA-binding protein 7; CHD-7; EC 3.6.4.12; ATP-dependent helicase CHD7
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production.
  • 基因功能參考文獻：
    1. Data show that chromodomain helicase DNA-binding protein 7 (Chd7) is required for the maintenance of open chromatin and thus activation of genes essential for granule neuron differentiation. PMID: 28317875
    2. CHD7 and CHD8 bind in Oligodendrocyte precursor cells to a majority of ASD risk-associated genes, suggesting an implication of oligodendrocyte lineage cells in ASD neurological defects. PMID: 30108144
    3. Findings extend current knowledge of the role of BMI1 and CHD7 in medulloblastoma pathogenesis, and they raise the possibility that pharmacological targeting of BMI1 or ERK may be particularly indicated in a subgroup of MB with low expression levels of CHD7. PMID: 29212025
    4. we have identified mild cerebellar hypoplasia and distinct cerebellar foliation anomalies in Chd7 gt/+ mice. Our findings imply a specific function for CHD7 in controlling the spatiotemporal initiation of cerebellar fissures and show that normal fissure formation requires bi-allelic Chd7 expression, consistent with the haploinsuffi- cient nature of CHARGE syndrome. PMID: 29168327
    5. Chd7 deficiency delays leukemia initiation induced by Cbfb-MYH11. PMID: 29018080
    6. CHD7 is an important factor in the proliferation and stemness maintenance of neural stem/progenitor cells. PMID: 27955690
    7. Chd7 regulates the proliferation and identity of oligodendrocyte precursor cells after spinal cord injury. PMID: 28931573
    8. CHD7 is necessary for maintaining an open, accessible chromatin state at the Reln locus. Taken together, this study shows that Reln gene expression is regulated by chromatin remodeling, identifies CHD7 as a previously unrecognized upstream regulator of Reln, and provides direct in vivo evidence that a mammalian CHD protein can control brain development PMID: 28165338
    9. Chd7 coordinates with Sox10 to regulate the initiation of myelinogenesis and acts as a molecular nexus of regulatory networks that account for the development of a seemingly diverse array of lineages, including oligodendrocytes and osteoblasts, pointing to previously uncharacterized Chd7 functions. PMID: 26928066
    10. Chd7 mutant mice are models for determining the molecular etiology of ocular defects in CHARGE syndrome. PMID: 26670829
    11. This work reveals the importance of CHD7 in the cardiogenic mesoderm for multiple processes during cardiovascular development. PMID: 26102480
    12. Findings directly link CHD7 to pathways involved in NSC quiescence and identify the first chromatin-remodeling factor with a role in NSC quiescence and maintenance. PMID: 25183173
    13. Conditional deletion of Chd7 in ectodermal and endodermal derivatives or migrating neural crest cells results in varied and severe craniofacial defects. PMID: 24975120
    14. CHD7 gene mutation is associated with CHARGE syndrome. PMID: 24728844
    15. Findings demonstrate critical, cooperative roles for Retinoic Acid (RA) and CHD7 in subventricular zone neural stem cell function and inner ear development, suggesting that altered RA signaling may be an effective method for treating Chd7 deficiency. PMID: 24026680
    16. Chd7 may have critical selector gene functions during inner ear morphogenesis. PMID: 22705977
    17. CHD7 may directly regulate Bmp4 expression by binding with an enhancer element downstream of the Bmp4 locus. PMID: 22658483
    18. Otitis media in Chd7Ome/+ mice is characterized by Eustachian tube dysfunction, epithelial hyperplasia, middle ear effusion and associated hearing loss. PMID: 22539951
    19. Chd7(Gt)(/+) mouse model of CHARGE syndrome demonstrates combined conductive and sensorineural hearing loss, correlating with changes in both middle and inner ears. PMID: 21875659
    20. characterize gene regulation by Sox2 in neural stem cells. We PMID: 21532573
    21. CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. PMID: 20591827
    22. enhancer-mediated gene dysregulation contributes to disease pathogenesis and the critical CHD7 target genes may be subject to positive or negative regulation. PMID: 20657823
    23. [review] recent and ongoing analyses of CHD7 function in mouse models and cell-based systems PMID: 20507341
    24. Conditional deletion of Chd7 in the developing otocyst using Foxg1-Cre resulted in cochlear hypoplasia and complete absence of the semicircular canals and cristae. PMID: 20736290
    25. The large number of mouse mutants may be due to the combination of the Chd7 gene being a large target and the fact that many heterozygous carriers of the mutations are viable individuals with a readily detectable phenotype PMID: 16207732
    26. Utility of Chd7 as a reporter-tagged loss-of-function allele for future studies exploring developmental mechanisms of Chd7 deficiency. PMID: 17334657
    27. Chd7(Gt/+) mice display variable asymmetric lateral and posterior semicircular canal malformations, as well as defects in vestibular sensory epithelial innervation despite the presence of intact hair cells in the target organs. PMID: 17701983
    28. Mammalian olfactory dysfunction due to Chd7 haploinsufficiency is linked to defects in olfactory neural stem cell proliferation. PMID: 19279158
    29. biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal pharyngeal arch artery development PMID: 19855134

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 組織特異性：
    Expressed in the outflow tract of the heart, optic vesicle, facio-acoustic preganglion complex, brain, olfactory pit, and mandibular component of the first branchial arch.
  • 數據庫鏈接：


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