在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Ceramide glucosyltransferase (Ugcg), partial

Recombinant Mouse Ceramide glucosyltransferase (Ugcg), partial

  • 中文名稱：
    小鼠Ugcg重組蛋白
  • 貨號：
    CSB-YP025564MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ugcg重組蛋白
  • 貨號：
    CSB-EP025564MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ugcg重組蛋白
  • 貨號：
    CSB-EP025564MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ugcg重組蛋白
  • 貨號：
    CSB-BP025564MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ugcg重組蛋白
  • 貨號：
    CSB-MP025564MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ugcg
  • Uniprot No.：
  • 別名：
    Ugcg; Ceramide glucosyltransferase; GLCT-1; Glucosylceramide synthase; GCS; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer. Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids.
  • 基因功能參考文獻：
    1. we report the development of a novel, orally available glucosylceramide synthase inhibitor (Genz-682452) with pharmacological and safety profiles that have potential for treating Fabry disease. PMID: 25938659
    2. These results suggest that neuronal glucosylceramide synthase expression modulates mediobasal hypothalamus insulin signaling and white adipose tissue function in fasted mice. PMID: 26038579
    3. we measured the expression and activities of Pgp and GCS, UDP-glucose levels, cellular uptake of C12-NBD-ceramide (a fluorescent analogue of ceramide) and ceramide-induced cell death in S and R cells. PMID: 25964538
    4. Data indicate that verexpression of glucosylceramide synthase in myotubes induces glucosylceramide but enhances insulin signaling. PMID: 24214972
    5. Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume. PMID: 23671696
    6. The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase). PMID: 23554574
    7. Data indicate that mice with cerebroside sulfotransferases (Cst) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst deficiency had lower ammonium excretion. PMID: 23716689
    8. glycosphingolipids in hepatocytes are not essential for sterol, glucose, or lipoprotein metabolism. Ugcg inhibitors exert their effect on hepatocytes either independently of GSL or mediated by other (liver) cell types. PMID: 20432257
    9. Ugcg and Ugt8a deficient oligodendroglial did not exhibit any phenotypic or myelin structural abnormalities; abundant and structurally intact myelin can form in their absence PMID: 19705459
    10. Shortly after birth UgcG deficient mice showed dysfunction of cerebellum and peripheral nerves, associated with structural defects PMID: 17867597

    顯示更多

    收起更多

  • 亞細胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family
  • 數據庫鏈接：


主站蜘蛛池模板： 国产欧美日韩精品专区| 深夜国产一区二区三区在线看| 国产99在线 | 免费| 青青草国产精品人人爱| 无码av免费网站| 伊人激情av一区二区三区| 成年日韩片av在线网站| 亚洲欧洲日产无码中文字幕| 图片区 小说区 区 亚洲五月| 色94色欧美sute亚洲线路二| 香蕉精品亚洲二区在线观看| 中老年熟妇激情啪啪大屁股| 成视频年人黄网站免费视频| 日本中国内射bbxx| 熟女毛多熟妇人妻在线视频| 狂野欧美激情性xxxx按摩| 亚洲v欧美v国产v在线观看| 日日鲁鲁鲁夜夜爽爽狠狠| 国产在线观看免费视频软件| 国产精品嫩草影院入口一二三| 国产人妻一区二区三区久| 成在人线av无码免观看麻豆| 欧美精品a∨在线观看| 日韩精品成人一区二区三区| 精品人妻少妇一区二区三区不卡 | 国产精品18久久久久久麻辣| 久久综合给综合给久久| 最近中文字幕mv在线视频看| 亚洲熟妇无码爱v在线观看| 国产乱人伦偷精品视频免下载| 精品久久国产综合婷婷五月| 日韩人妻无码中文字幕视频| 45分钟免费真人视频| 真人做受试看120分钟小视频| 国产亚洲人成网站在线观看| 中文字幕无码精品亚洲35| 四川少妇大战4黑人| 国产女人高潮嗷嗷嗷叫| 午夜爽爽爽男女免费观看影院| 熟女人妻aⅴ一区二区三区60路| 国产高清亚洲精品视bt天堂频 |