在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Cell cycle checkpoint control protein RAD9A (Rad9a)

Recombinant Mouse Cell cycle checkpoint control protein RAD9A (Rad9a)

  • 中文名稱：
    小鼠Rad9a重組蛋白
  • 貨號(hào)：
    CSB-YP896673MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rad9a重組蛋白
  • 貨號(hào)：
    CSB-EP896673MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rad9a重組蛋白
  • 貨號(hào)：
    CSB-EP896673MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rad9a重組蛋白
  • 貨號(hào)：
    CSB-BP896673MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rad9a重組蛋白
  • 貨號(hào)：
    CSB-MP896673MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rad9a; Rad9; Cell cycle checkpoint control protein RAD9A; mRAD9; EC 3.1.11.2; DNA repair exonuclease rad9 homolog A; Rad9-like protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-389
  • 氨基酸序列
    MKCLITGGNV KVLGKAVHSL SRIGDELYLE PLKDGLSLRT VNSSRSAYAC FLFAPLFFQQ YQAASPGQDL LRCKILMKAF LSVFRSLAIV EKSVEKCCIS LSGSHSHLVV QLHCKYGVKK THNLSFQDCE SLQAVFDPAS CPHLLRTPAR VLAEAVLSFP LALTEVTLGI GRGRRVILRS YQEEEADSTS KAMVTETSIG DEDFQQLHAP EGIAVTFCLK EFRGLLSFAE SANLPLTIHF DVPGRPVIFT IEDSLLDAHF VLATLLEQDS CSQGPCSPKP HQPVPQKQAH STPHLDDFTS DDIDCYMIAM ETTGGNEGSG AQPSTSLPPV SLASHDLAPT SEEEAEPSTV PGTPPPKKFR SLFFGSILAP VHSPQGPNPV LAEDSDGEG
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.
  • 基因功能參考文獻(xiàn)：
    1. Rad9a is indispensable for spermatogonia differentiation and testicular development in mice. PMID: 27861152
    2. RAD9 has a prominent role in the ATR-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling. PMID: 26667770
    3. We demonstrated that Mrad9 null enhances chromatid aberration frequency induced by radiation in bystander mouse embryonic stem cells PMID: 25234738
    4. RAD9A is essential for male fertility and for repair of DNA double-strand breaks during meiotic prophase I. PMID: 23788429
    5. A review of the many activities assigned to Rad9, and speculation as to which influence its function in tumor development. PMID: 22034047
    6. Data show that Rad9 plays dual roles in generating functional antibodies and in maintaining the integrity of the whole genome in B cells. PMID: 20729201
    7. Rad9A-mediated Claspin localization is a vital step during checkpoint activation. PMID: 20081369
    8. tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1, but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9. PMID: 20021694
    9. HRAD9 and Mrad9 are part of a gene family and reveal a new genetic element encoding a product that interacts with multiple, known cell cycle checkpoint control proteins. PMID: 14500360
    10. Results establish mouse rad9 as a key mammalian genetic element of pathways that regulate the cellular response to DNA damage, maintenance of genomic integrity, and proper embryonic development. PMID: 15282322
    11. The encoded mammalian proteins participate in promoting resistance to DNA damage, cell cycle checkpoint control, DNA repair, and apoptosis. PMID: 16365875
    12. Rad9 levels are high in prostate cancer cells due at least in part to aberrant methylation or gene amplification PMID: 18316588
    13. Mrad9 plays an important role in maintaining genomic stability and preventing tumor development in keratinocytes PMID: 18632607
    14. These results suggest that phosphorylation of Rad9 plays a critical role in the activation of the S phase/Mitosis checkpoint, and that downstream proteins cdc2 and 14-3-3sigma mediate this function. PMID: 18769057
    15. Rad9 is a signal in the earlier stage of epithelial cell cycle regulation and plays protective roles in alveolar epithelial cells in the pathogenesis of acute lung injury. PMID: 18809378
    16. Disruption of the Rad9-MLH1 interaction by a single-point mutation in Rad9 leads to significantly reduced DNA mismatch repair activity. PMID: 18842633

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Rad9 family
  • 組織特異性：
    Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 国产人成无码视频在线观看| 少妇被又大又粗又爽毛片| 无码丰满熟妇bbbbxxx| 亚洲熟妇av一区二区三区漫画| 色护士极品影院| 日韩精品无码中文字幕一区二区| 波多野结av在线无码中文| 欧美综合天天夜夜久久| 成av免费大片黄在线观看| 最新精品国偷自产在线| 少妇午夜啪爽嗷嗷叫视频| 国产手机在线亚洲精品观看| 亚洲综合无码av一区二区三区 | 中文字幕爆乳julia女教师| 日产电影一区二区三区| 天天拍夜夜添久久精品| 亚洲一二区制服无码中字| 日韩a∨精品日韩在线观看| 国产精品日韩av在线播放| 一本大道久久东京热av| 久久久99精品成人片中文字幕| 熟女人妻aⅴ一区二区三区60路 | 国产麻豆天美果冻无码视频| 中文字幕人成乱码熟女香港| 久久久噜噜噜久久熟女| 丰满大肥婆肥奶大屁股| 日本55丰满熟妇厨房伦| 成 人 黄 色 大片| 在线看免费无码av天堂的| 欧美牲交a欧美牲交aⅴ一| 琪琪女色窝窝777777| 成 人 综合 亚洲另类| 最近最好的中文字幕2019免费 | 欧美激情一区二区| 亚洲另类欧美综合在线 | 日韩精品人妻系列无码专区免费| 久热在线这里只有精品国产| 中文字幕乱码熟妇五十中出色欲| 性猛交ⅹxxx富婆视频| 国产α片免费观看在线人 | 乱中年女人伦av二区|