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  4. Recombinant Mouse Caspase recruitment domain-containing protein 11 (Card11), partial

Recombinant Mouse Caspase recruitment domain-containing protein 11 (Card11), partial

  • 中文名稱：
    Recombinant Mouse Caspase recruitment domain-containing protein 11(Card11) ,partial
  • 貨號：
    CSB-YP809301MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Caspase recruitment domain-containing protein 11(Card11) ,partial
  • 貨號：
    CSB-EP809301MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Caspase recruitment domain-containing protein 11(Card11) ,partial
  • 貨號：
    CSB-EP809301MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Caspase recruitment domain-containing protein 11(Card11) ,partial
  • 貨號：
    CSB-BP809301MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Caspase recruitment domain-containing protein 11(Card11) ,partial
  • 貨號：
    CSB-MP809301MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Card11; Caspase recruitment domain-containing protein 11
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement. Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways. Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.
  • 基因功能參考文獻：
    1. IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets. PMID: 29649481
    2. LRRK1 physically interacted and potently synergized with CARMA1 to enhance NF-kappaB activation. PMID: 27166870
    3. synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model PMID: 27560392
    4. CARMA1 clustering through SH3-GUK domain interactions is required for its activation of NF-kappaB signalling PMID: 25602919
    5. data suggest that Carma1 and MALT1 play previously unappreciated roles in the activation of mTOR signaling in T cells after engagement of the TCR. PMID: 24917592
    6. CARMA1 CARD shows the first homo-dimeric structure of CARD formed by a disulfide bond and reveals a possible biologically important homo-dimerization mechanism PMID: 24224005
    7. Data indicate that caspase recruitment domain-containing protein 11 (CARD11) is involved in the pathogenesis of collagen-induced arthritis (CIA) by formation of the CARD11/Bcl10 complex and enhancement of the Th17 cell response. PMID: 24443940
    8. Genetic approach demonstrates a critical role for the CARD function of CARMA1 in Treg cell development in vivo. PMID: 24383645
    9. both CARMA1 CARD and BCL10 CARD easily self-oligomerized under physiological conditions. PMID: 23525237
    10. Findings show that regulation of CARD11 signaling is a critical switch governing the decision between death and proliferation in antigen-stimulated mature B cells. PMID: 23027925
    11. TCR/CARMA1/NF-kappaB controls completion of Th17 differentiation. PMID: 23091043
    12. These studies provide molecular insight into the assembly of CARMA1 and BCL10. PMID: 22880103
    13. Upregulation of CARMA1 in vivo results in Th2 cell-mediated inflammation. Mice expressing constitutively active CARMA1 have elevated IL-4, IL-5, and IL-10 and spontaneously develop pulmonary inflammation and eosinophilia. PMID: 22371397
    14. We show that CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1 PMID: 22323537
    15. Adoptive transfer of T helper cell (Th)2-polarized OX40+CARMA1-deficient antigen-specific CD4+ T cells into wild-type mice induces less airway inflammation in response to antigen challenge than does the transfer of wild-type Th2 cells. PMID: 22075698
    16. Decreased T-cell receptor signaling through CARD11 differentially compromises Foxp3 regulatory T-cell suppression that result in selective Th2 dysregulation and allergic disease. PMID: 21320717
    17. CARMA1 regulates IL-2 receptor signaling and controls the IL-2-stimulated maturation of Treg precursors to mature Tregs PMID: 20233721
    18. the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation PMID: 20164171
    19. found that antigen receptor-activated CARMA1 underwent lysine 48 (K48) polyubiquitination and proteasome-dependent degradation. PMID: 20008554
    20. CARMA1 phosphorylation controls NF-kappaB activation by triggering a shift from an inactive to an active CARMA1 conformer. PMID: 16356855
    21. CARMA1 is essential for the development of allergic airway inflammation through its role in T lymphocytes; mice with a deletion in the CARMA1 gene do not develop inflammation in a murine model of asthma. PMID: 16751370
    22. CARMA1-deficient B cells are defective in CD40-induced proliferation. PMID: 17048267
    23. The active caspase-8c-FLIP complex forms in the absence of Fas (CD95/APO1) and associates with the NF-kappaB signaling molecules RIP1, TRAF2, and TRAF6, as well as upstream NF-kappaB regulators PKC theta, CARMA1, Bcl-10, and MALT1 PMID: 17462996
    24. findings provide new insights into ADAP function and the mechanism by which CARMA1 regulates NF-kappaB activation in T cells PMID: 17478723
    25. demonstrate a key role for Bcl10 signalosomes in the activation of canonical NF-kappaB signaling as well as JNK and p38 MAPK upon NK-cell triggering. Bcl10 directly cooperates with Malt1 and depends on Carma1 but not on Card9 for NK-cell activation PMID: 18192506
    26. NF-kappaB activation signaling through ITAM receptors is regulated by a cell type-specific mechanism depending on the usage of adaptors CARMA1 and CARD9, which determines the PKC dependence of the signaling. PMID: 18606643
    27. CARMA1 is essential for Treg development, but is not necessary for the development of other agonist-selected T-cell subsets. Overall, these data reveal an important but differential role for CARMA1-mediated TCR signaling in T-cell development. PMID: 19130560
    28. Here we show that mice with a Carma1 point mutation lack thymic CD4(+)Foxp3(+) T(reg) cells and demonstrate a cell-intrinsic requirement for CARMA1 in thymic Foxp3 induction. PMID: 19260764
    29. TCR- CARMA1/Bcl10/Malt1 -dependent signals are essential to commit immature thymocytes to the nTreg lineage. PMID: 19454668
    30. Cbl-b binds and promotes monoubiquitination to CARMA1, a critical signaling molecule in NFkappaB activation. PMID: 19815501

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  • 亞細胞定位：
    Cytoplasm. Membrane raft.
  • 數據庫鏈接：


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