在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Carbohydrate-responsive element-binding protein (Mlxipl), partial

Recombinant Mouse Carbohydrate-responsive element-binding protein (Mlxipl), partial

  • 中文名稱：
    小鼠Mlxipl重組蛋白
  • 貨號：
    CSB-YP860828MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mlxipl重組蛋白
  • 貨號：
    CSB-EP860828MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mlxipl重組蛋白
  • 貨號：
    CSB-EP860828MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mlxipl重組蛋白
  • 貨號：
    CSB-BP860828MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mlxipl重組蛋白
  • 貨號：
    CSB-MP860828MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Mlxipl; Mio; Wbscr14Carbohydrate-responsive element-binding protein; ChREBP; MLX interactor; MLX-interacting protein-like; Williams-Beuren syndrome chromosomal region 14 protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.
  • 基因功能參考文獻：
    1. ChREBP and SHP control the regulation of hepatic microsomal triglyceride transfer protein expression and VLDL Secretion. Adenoviral Overexpression of ChREBP and SHP Respectively Increased and Decreased Mttp Expression. PMID: 29518948
    2. Data, including data from studies in knockout mice, suggest that ChREBP is involved in coordinate regulation of sucrose and fructose absorption/metabolism by modulating gene expression in intestinal mucosa and liver. PMID: 29534502
    3. Authors have identified a previously unappreciated negative feedback loop by which glucose-induced ChREBP-beta downregulates ChREBP-alpha-signaling providing new insight into the physiological role of islet ChREBP-beta and into the regulation of glucose-induced gene expression. PMID: 27900263
    4. loss of adipose-ChREBP is sufficient to cause insulin resistance potentially by regulating AT glucose transport. PMID: 29069585
    5. Glucose-challenged Chrebp-/- mice exhibit a marked reduction in FGF21 production. PMID: 29020627
    6. Study identify O-GlcNAcylation on Ser514 in the C-terminus of ChREBP and validate two important sites, Thr517 and Ser839 for O-GlcNAcylation and their function. Ser514 phosphorylation enhances ChREBP O-GlcNAcylation, maintaining the transcriptional activity of ChREBP; Ser839 O-GlcNAcylation is essential for its heterodimerization, DNA-binding activity, and nuclear export. PMID: 28450420
    7. findings suggest that a previously unknown link exists between ChREBP and the regulation of cholesterol synthesis that affects liver injury. PMID: 28628039
    8. findings also identified a role for ChREBP in regulating SREBP2-dependent cholesterol metabolism. PMID: 28628040
    9. these findings support a carbohydrate-mediated, ChREBP-driven mechanism that contributes to hepatic insulin resistance. PMID: 27669460
    10. a high complex carbohydrate diet selectively increases hepatic ChREBPbeta expression, which associates with hepatic steatosis but not insulin resistance. In contrast, a high fat diet reduces adipose ChREBP, which associates with inflammation and insulin resistance. PMID: 27992582
    11. The results revealed the novel mechanism by which HNF-4alpha promoted ChREBP transcription in response to glucose, and also demonstrated that ChREBP-alpha and HNF-4alpha synergistically increased ChREBP-beta transcription. PMID: 27029511
    12. Adipose tissue mTORC2 regulates via Rictor ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. PMID: 27098609
    13. Diet-induced obesity increases basal expression of ChREBPbeta, which may increase the risk of developing hepatic steatosis, and fructose-induced activation is independent of gluconeogenesis. PMID: 26526060
    14. Targeted deletion of ChREBP in bone marrow cells resulted in accelerated atherosclerosis progression in Ldlr-/- mice with increased monocytosis, lesional macrophage accumulation, and plaque necrosis. PMID: 26411684
    15. Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism. PMID: 26910886
    16. Data show that the weight gain was blunted in male, but not female, fatty acid binding protein 4-Cre-driven promoter (FaChOX) mice when placed on either a normal chow diet or an obesogenic Western diet. PMID: 26248218
    17. Data show that carbohydrate-response element-binding protein (ChREBP) activation induces peroxisome proliferator-activated receptor (PPARgamma) activity and ChREBP inhibition impairs differentiation. PMID: 26181104
    18. Data suggest expression of ChREBPbeta isoform is up-regulated in pancreatic beta-cells in response to elevated glucose (i.e., hyperglycemic conditions); RNA interference of ChREBPbeta prevents beta-cell proliferation in response to hyperglycemia. PMID: 26384380
    19. hyperinsulinemia may cause glycolipid metabolic disorders by up-regulating the expression of ChREBP PMID: 25212036
    20. The effects of ethanol on AMPK and PP2A may result in activation of ChREBP, providing another potential mechanism for ethanol-induced hepatic steatosis. PMID: 23266705
    21. Depletion of ChREBP decreased glucose-stimulated proliferation in beta-cells isolated from ChREBP(-/-) mice, in INS-1-derived 832/13 cells, and in primary rat and human beta-cells PMID: 22586588
    22. Data indicate that ChREBP is a key transcription factor that mediates many of the hyperglycaemia-induced activations in a gene expression programme that underlies beta cell glucotoxicity at the molecular, cellular and whole animal levels. PMID: 22382520
    23. ChREBP overexpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible for the conversion of saturated fatty acids (SFAs) into MUFAs PMID: 22546860
    24. adipose ChREBP is a major determinant of adipose tissue fatty acid synthesis and systemic insulin sensitivity PMID: 22466288
    25. an important mechanism by which importin-alpha and 14-3-3 control movement of ChREBP in and out of the nucleus in response to changes in glucose levels in liver PMID: 21665952
    26. ChREBP was unexpectedly required during fasting for maximal Rgs16 transcription in liver and in cultured primary hepatocytes during gluconeogenesis. PMID: 21357625
    27. Results reveal that O-GlcNAcylation represents an important novel regulation of ChREBP activity in the liver under both physiological and pathophysiological conditions. PMID: 21471514
    28. ChREBP is a critical and direct mediator of glucose repression of PPARalpha gene expression in pancreatic beta-cells PMID: 21282101
    29. Carbohydrate response element-binding protein (ChREBP), a glucose-dependent transcription factor downstream of Protein phosphatase 2A, partially mediated the effects of glucose on metabolic markers. PMID: 21215280
    30. The db/db mouse exhibits significantly higher liver ChREBP activity, which may be associated with the development of hepatic steatosis frequently occurring in type 2 diabetes. PMID: 19727214
    31. Data showed that the steatosis is accompanied by altered expression of a number of genes, including increased expression of ChREBP, which acts as one of the central determinants of lipid synthesis in the liver. PMID: 21103071
    32. low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis PMID: 21084751
    33. ChREBP is an attractive target to alleviate derangements in lipid metabolism observed in patients with glycogen storage disease. PMID: 20854262
    34. ChREBP inactivation in clonal pancreatic MIN6 beta-cells results in an increase in Pdx-1 expression at low glucose and to a small, but significant, increase in Ins2, GcK and MafA gene expression at high glucose concentrations. PMID: 20934404
    35. Data demonstrate that expression of carbohydrate response element-binding protein (ChREBP or Mlxipl), an important transcriptional regulator of carbohydrate metabolism, is significantly affected in compound Foxa1/a2 mutant beta-cells. PMID: 20534694
    36. These multiple lines of evidence support the conclusion that G-6-P mediates the activation of ChREBP. PMID: 20382127
    37. ChREBP acts as a novel repressor of the ARNT/HIF-1beta gene and thus may contribute to beta-cell dysfunction induced by glucotoxicity. PMID: 19833882
    38. ChREBP is important modulator of adipocytes and its expression in adipose tissue is subject to combined regulation by glucose and insulin. Induction of ChREBP may serve as novel pharmacological pathway for troglitazone-mediated hypoglycemic effects. PMID: 15100094
    39. is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo PMID: 15118080
    40. role of ChREBP in the glucose regulation of two key liver lipogenic enzymes, acetyl-CoA carboxylase and fatty acid synthase PMID: 15496471
    41. The results of this study suggest that inactivation of ChREBP expression not only reduces fat synthesis and obesity in ob/ob mice but also results in improved glucose tolerance and appetite control. PMID: 16705063
    42. results demonstrate that carbohydrate responsive element-binding protein (ChREBP) is central for the regulation of lipogenesis in vivo and plays a determinant role in the development of the hepatic steatosis and of insulin resistance in ob/ob mice PMID: 16873678
    43. ChREBP is a critical regulator of lipogenic genes in the beta cell and may play a role in the development of glucolipotoxicity and beta cell failure through alteration of gene expression in type 2 diabetes PMID: 16891625
    44. The shift from fat utilization to pyruvate and lactate utilization resulted in a decrease in the energy of ATP hydrolysis and a hypo-energetic state in the livers of ChREBP(-/-) mice. PMID: 18042547
    45. ChREBP can regulate metabolic gene expression to convert excess carbohydrate into triglyceride rather than glycogen.[review] PMID: 18490833
    46. Phosphorylation of ChREBP was essential for its interaction with CRM1 for export to the cytosol, whereas nuclear import of ChREBP requires dephosphorylated ChREBP to interact with importin alpha. PMID: 18606808
    47. The transcription factor ChRepsilonBP is a major mediator of glucose action on lipogenic genes & a key determinant of lipid synthesis in vitro. In mice, it plays a central role in hepatic steatosis & insulin resistance physiopathology. Review. PMID: 18950580
    48. study demonstrated that thyroid hormone up-regulated ChREBP mRNA and protein expression in liver PMID: 19324998

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in the ventricular and intermediate zones of the developing spinal cord of E12.5 embryos. In later embryos expressed in a variety of tissues.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 99视频精品国产免费观看| 久久久久久成人毛片免费看| 欧美成人一区二区三区在线观看| 天天摸夜夜摸夜夜狠狠摸| 国产a√精品区二区三区四区 | 国产av成人精品播放| 精品国产中文字幕在线视频| 天堂网在线观看| 国产一区二区| 大肉大捧一进一出视频出来呀 | 蜜桃少妇av久久久久久久 | 国产精品ⅴ无码大片在线看| 亚洲一二三四2021不卡| 992tv精品视频tv在线观看| 成人亚洲精品777777| 日本公妇乱偷中文字幕 | 成人亚洲欧美一区二区三区| 日韩国产精品人妻无码久久久| 插一插射一射视频| 日韩国产成人精品视频| 久久视频这里只精品| 亚洲 制服 丝袜 无码 在线| 日本乱子伦一区二区三区| 色狠狠色噜噜av天堂一区| 中文天堂在线www最新版官网| 国产办公室无码视频在线观看| 久久精品中文字幕有码| 久久伊人蜜桃av一区二区| 亚洲ⅴ国产v天堂a无码二区| 99视频国产精品免费观看| 波多野结衣办公室33分钟| 精品亚洲一区二区三区在线观看| 看国产黄大片在线观看| 国产成人麻豆亚洲综合精品| 国产偷国产偷亚洲高清日韩| 国产又爽又黄又不遮挡视频| 香港三日本三级少妇三级2021| 亚洲 日本 欧美 中文幕| 九色porny丨国产首页注册| 婷婷五月开心亚洲综合在线| 狠狠色噜噜狠狠狠狠777米奇小说|