在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Calcium/calmodulin-dependent protein kinase type II subunit beta (Camk2b)

Recombinant Mouse Calcium/calmodulin-dependent protein kinase type II subunit beta (Camk2b)

  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號(hào)：
    CSB-YP004466MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號(hào)：
    CSB-EP004466MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號(hào)：
    CSB-EP004466MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號(hào)：
    CSB-BP004466MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號(hào)：
    CSB-MP004466MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Camk2b; Camk2d; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; EC 2.7.11.17
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-542
  • 氨基酸序列
    MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK NSSAITSPKG SLPPAALEPQ TTVIHNPVDG IKESSDSTNT TIEDEDAKAR KQEIIKTTEQ LIEAVNNGDF EAYAKICDPG LTSFEPEALG NLVEGMDFHR FYFENLLAKN SKPIHTTILN PHVHVIGEDA ACIAYIRLTQ YIDGQGRPRT SQSEETRVWH RRDGKWQNVH FHCSGAPVAP LQ
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
  • 基因功能參考文獻(xiàn)：
    1. Region-specific overexpression of betaCaMKII in dentate gyrus (DG) impairs behavioral flexibility, and severely attenuates the NMDAR-dependent long-term depression (LTD) in DG medial perforant path, which is further confirmed by the diminished AMPAR internalization and dephosphorylation during LTD. PMID: 27993520
    2. data suggest that phosphorylation of CaMKIIbeta through the mGluR/IP3R1/PKC signaling pathway represses excessive spine formation and elongation in mature Purkinje cells. PMID: 28607044
    3. The molecular, temporal and region-specific requirements of the CAMK2B in mouse locomotion have been described. PMID: 27244486
    4. Study used an unbiased semiquantitative proteomics approach to identify biologically relevant phosphorylation sites on both CaMKIIa and CaMKIIb PMID: 25650780
    5. CaMKK/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia. PMID: 23868268
    6. Our data point toward a critical role of CaMKIIbeta in regulating oligodendrocyte maturation and CNS myelination via an actin-cytoskeleton-regulatory mechanism PMID: 23785157
    7. Muscle-specific CamkIIss isoform is critical for receptor recycling and may provide a mechanism by which the postsynaptic acetylcholine receptor density is maintained at the neuromuscular junction in vivo. PMID: 20844140
    8. is expressed in motor neurons during axon outgrowth and is part of slow axonal transport. PMID: 11891785
    9. accumulated in the nuclei of brain cells by pentylenetetrazol-mediated seizure via cellular mechanisms other than transcriptional and post-transcriptional regulation PMID: 11897160
    10. Ca/CaMK II activation plays an important role in the transmission of GnRH signals from the plasma membrane to the LH subunit genes. PMID: 12746302
    11. Expression of an active form of CaMKII beta after 1 day of T cell activation enhances initial proliferation and cytotoxic T cell activity, but induces profound unresponsiveness to peptide restimulation. PMID: 15843557
    12. activated CaMKII directly phosphorylated the recombinant COOH-terminal region of FAK at a residue equivalent to Ser-843 PMID: 15845548
    13. CaM kinase IIdelta2 was involved in the GnRH-induced activation of MAP kinase in GT1-7 cells. PMID: 17706588
    14. betaCaMKII activity in the dentate gyrus selectively impaired long-term potentiation in the dentate perforant path, but not in the CA1 Schaffer collateral pathway. PMID: 17913888
    15. We found that betaCaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse PMID: 19503086
    16. Deletion studies indicated three important parts of beta CaM kinase II: beta-specific insertion 2, the association domain, and the oligomeric form; all 3 play an important role in its cellular distribution. PMID: 11532017

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:12323

    UniGene: Mm.439733



主站蜘蛛池模板： 免费的污污的网站在线观看| 欧美日韩国产免费一区二区三区| 人妻另类 专区 欧美 制服| 人妻少妇邻居少妇好多水在线| 草草影院精品一区二区三区| 国产一区视频一区欧美| 国产精品人人做人人爽人人添| 久久不见久久见中文字幕免费| 99在线精品免费视频九九视| 亚洲伊人色综合www962| 国产成人高清亚洲一区妲妃| 亚洲人成图片小说网站| 国产av丝袜旗袍无码网站| www夜片内射视频日韩精品成人 | 亚洲国产精品成人影片久久| av无码免费永久在线观看| 麻豆精品久久久久久久99蜜桃| 欧美金妇欧美乱妇xxxx| 蜜桃日本免费观看mv| 欧美人禽zozo动人物杂交| 国产露脸150部国语对白| 日韩中文字幕免费视频| 精品噜噜噜噜久久久久久久久| 另类亚洲小说图片综合区| 日本熟妇乱人伦a片免费高清| 成品人视频ww入口| 亚洲中文字幕在线无码一区二区| 色窝窝免费播放视频在线| 色老头在线一区二区三区| 美女国产毛片a区内射| 精品国内自产拍在线播放观看| 亚洲乱码在线卡一卡二卡新区豆瓣 | 午夜人妻理论片天堂影院| 99久久99久久精品免费观看 | 亚洲国产综合在线观看不卡| 久久人妻精品白浆国产| 欧美亚洲日韩国产人成在线播放| 麻豆蜜桃av蜜臀av色欲av| 色噜噜亚洲男人的天堂www| 一二三四区无产乱码1000集| 久久久无码人妻精品一区|